Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891242226> ?p ?o ?g. }
- W2891242226 endingPage "3678" @default.
- W2891242226 startingPage "3671" @default.
- W2891242226 abstract "Many inflammatory mediators are involved in the process of carcinogenesis and cancer progression. In addition to cytokines and chemokines, lipid mediators have recently attracted attention as signaling molecules associated with inflammatory diseases. Sphingosine‐1‐phosphate (S1P) is a pleiotropic lipid mediator that regulates cell survival and migration, immune cell recruitment, angiogenesis and lymphangiogenesis. S1P also plays a significant role in inflammation and cancer. The gradation of S1P concentration in the blood, lymph and tissue regulates lymphocyte trafficking, an important component of inflammation. Furthermore, cancer cells produce elevated levels of S1P, contributing to the tumor microenvironment and linking cancer and inflammation. Future technological advances may reveal greater detail about the mechanisms of S1P regulation in the tumor microenvironment and the contribution of S1P to cancer progression. Considering the critical role of S1P in linking inflammation and cancer, it is possible that the S1P signaling pathway could be a novel therapeutic target for cancers with chronic inflammation." @default.
- W2891242226 created "2018-09-27" @default.
- W2891242226 creator A5036289394 @default.
- W2891242226 creator A5056655144 @default.
- W2891242226 creator A5057255416 @default.
- W2891242226 creator A5061509682 @default.
- W2891242226 creator A5076017842 @default.
- W2891242226 date "2018-10-15" @default.
- W2891242226 modified "2023-10-16" @default.
- W2891242226 title "The role of sphingosine‐1‐phosphate in inflammation and cancer progression" @default.
- W2891242226 cites W1781293224 @default.
- W2891242226 cites W1868247522 @default.
- W2891242226 cites W1967986099 @default.
- W2891242226 cites W1974735495 @default.
- W2891242226 cites W1977644244 @default.
- W2891242226 cites W1982334431 @default.
- W2891242226 cites W1983079076 @default.
- W2891242226 cites W1994519338 @default.
- W2891242226 cites W1996192399 @default.
- W2891242226 cites W1996605319 @default.
- W2891242226 cites W1998033088 @default.
- W2891242226 cites W2001253651 @default.
- W2891242226 cites W2003922930 @default.
- W2891242226 cites W2006639171 @default.
- W2891242226 cites W2006985918 @default.
- W2891242226 cites W2009021880 @default.
- W2891242226 cites W2013717051 @default.
- W2891242226 cites W2019209482 @default.
- W2891242226 cites W2021433993 @default.
- W2891242226 cites W2022770236 @default.
- W2891242226 cites W2023691306 @default.
- W2891242226 cites W2023760000 @default.
- W2891242226 cites W2028191845 @default.
- W2891242226 cites W2034825007 @default.
- W2891242226 cites W2046859247 @default.
- W2891242226 cites W2051698951 @default.
- W2891242226 cites W2054835096 @default.
- W2891242226 cites W2056697413 @default.
- W2891242226 cites W2070677984 @default.
- W2891242226 cites W2075794294 @default.
- W2891242226 cites W2080854536 @default.
- W2891242226 cites W2085852125 @default.
- W2891242226 cites W2088248538 @default.
- W2891242226 cites W2103456976 @default.
- W2891242226 cites W2103966836 @default.
- W2891242226 cites W2108091182 @default.
- W2891242226 cites W2109597409 @default.
- W2891242226 cites W2111097423 @default.
- W2891242226 cites W2114926817 @default.
- W2891242226 cites W2115639400 @default.
- W2891242226 cites W2116554142 @default.
- W2891242226 cites W2117692326 @default.
- W2891242226 cites W2119802141 @default.
- W2891242226 cites W2123105952 @default.
- W2891242226 cites W2132260833 @default.
- W2891242226 cites W2134340975 @default.
- W2891242226 cites W2136466723 @default.
- W2891242226 cites W2137116513 @default.
- W2891242226 cites W2144347270 @default.
- W2891242226 cites W2145876349 @default.
- W2891242226 cites W2149615364 @default.
- W2891242226 cites W2151217876 @default.
- W2891242226 cites W2151320729 @default.
- W2891242226 cites W2151340435 @default.
- W2891242226 cites W2152730481 @default.
- W2891242226 cites W2156445027 @default.
- W2891242226 cites W2161269202 @default.
- W2891242226 cites W2162838509 @default.
- W2891242226 cites W2216912734 @default.
- W2891242226 cites W2245992083 @default.
- W2891242226 cites W2262329766 @default.
- W2891242226 cites W2276827481 @default.
- W2891242226 cites W2394518860 @default.
- W2891242226 cites W2406417533 @default.
- W2891242226 cites W2441191196 @default.
- W2891242226 cites W2462355356 @default.
- W2891242226 cites W2465983866 @default.
- W2891242226 cites W2486752612 @default.
- W2891242226 cites W2531775529 @default.
- W2891242226 cites W2566704442 @default.
- W2891242226 cites W2606476433 @default.
- W2891242226 cites W2769383666 @default.
- W2891242226 cites W2775102332 @default.
- W2891242226 cites W2787500097 @default.
- W2891242226 cites W2790683184 @default.
- W2891242226 cites W2793775313 @default.
- W2891242226 cites W2801291179 @default.
- W2891242226 cites W2810739650 @default.
- W2891242226 cites W2826918501 @default.
- W2891242226 doi "https://doi.org/10.1111/cas.13802" @default.
- W2891242226 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6272099" @default.
- W2891242226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30238699" @default.
- W2891242226 hasPublicationYear "2018" @default.
- W2891242226 type Work @default.
- W2891242226 sameAs 2891242226 @default.
- W2891242226 citedByCount "69" @default.
- W2891242226 countsByYear W28912422262019 @default.
- W2891242226 countsByYear W28912422262020 @default.