FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891243896> ?p ?o ?g. }

• W2891243896 abstract "We previously determined that repeated binge ethanol drinking produced sex differences in the regulation of signaling downstream of Group 1 metabotropic glutamate receptors in the nucleus accumbens (NAc) of adult C57BL/6J mice. The purpose of the present study was to characterize RNA expression differences in the NAc of adult male and female C57BL/6J mice following 7 binge ethanol drinking sessions, when compared with controls consuming water. This binge drinking procedure produced high intakes (average >2.2 g/kg/30 min) and blood ethanol concentrations (average >1.3 mg/ml). Mice were euthanized at 24 h after the 7th binge session, and focused qPCR array analysis was employed on NAc tissue to quantify expression levels of 384 genes in a customized Mouse Mood Disorder array, with a focus on glutamatergic signaling (3 arrays/group). We identified significant regulation of 50 genes in male mice and 70 genes in female mice after 7 ethanol binges. Notably, 14 genes were regulated in both males and females, representing common targets to binge ethanol drinking. However, expression of 10 of these 14 genes was strongly dimorphic (e.g., opposite regulation for genes such as Crhr2, Fos, Nos1, and Star), and only 4 of the 14 genes were regulated in the same direction (Drd5, Grm4, Ranbp9, and Reln). Interestingly, the top 30 regulated genes by binge ethanol drinking for each sex differed markedly in the male and female mice, and this divergent neuroadaptive response in the NAc could result in dysregulation of distinct biological pathways between the sexes. Characterization of the expression differences with Ingenuity Pathway Analysis was used to identify Canonical Pathways, Upstream Regulators, and significant Biological Functions. Expression differences suggested that hormone signaling and immune function were altered by binge drinking in female mice, whereas neurotransmitter metabolism was a central target of binge ethanol drinking in male mice. Thus, these results indicate that the transcriptional response to repeated binge ethanol drinking was strongly influenced by sex, and they emphasize the importance of considering sex in the development of potential pharmacotherapeutic targets for the treatment of alcohol use disorder." @default.
• W2891243896 created "2018-09-27" @default.
• W2891243896 creator A5003781135 @default.
• W2891243896 creator A5012159936 @default.
• W2891243896 creator A5015174459 @default.
• W2891243896 creator A5021540971 @default.
• W2891243896 creator A5027494117 @default.
• W2891243896 creator A5040874962 @default.
• W2891243896 creator A5041043150 @default.
• W2891243896 creator A5063560666 @default.
• W2891243896 date "2018-09-10" @default.
• W2891243896 modified "2023-10-17" @default.
• W2891243896 title "Binge Ethanol Drinking Produces Sexually Divergent and Distinct Changes in Nucleus Accumbens Signaling Cascades and Pathways in Adult C57BL/6J Mice" @default.
• W2891243896 cites W1503193875 @default.
• W2891243896 cites W1544484095 @default.
• W2891243896 cites W1966943396 @default.
• W2891243896 cites W1971831953 @default.
• W2891243896 cites W1984997695 @default.
• W2891243896 cites W1985241009 @default.
• W2891243896 cites W1990285131 @default.
• W2891243896 cites W1991054433 @default.
• W2891243896 cites W1994788276 @default.
• W2891243896 cites W2000142411 @default.
• W2891243896 cites W2000853777 @default.
• W2891243896 cites W2005635370 @default.
• W2891243896 cites W2007140413 @default.
• W2891243896 cites W2007816267 @default.
• W2891243896 cites W2010717254 @default.
• W2891243896 cites W2011747720 @default.
• W2891243896 cites W2013282142 @default.
• W2891243896 cites W2016339318 @default.
• W2891243896 cites W2021594631 @default.
• W2891243896 cites W2022746377 @default.
• W2891243896 cites W2028697771 @default.
• W2891243896 cites W2034478005 @default.
• W2891243896 cites W2037720153 @default.
• W2891243896 cites W2041018266 @default.
• W2891243896 cites W2041893385 @default.
• W2891243896 cites W2048970463 @default.
• W2891243896 cites W2049163404 @default.
• W2891243896 cites W2052790580 @default.
• W2891243896 cites W2060041930 @default.
• W2891243896 cites W2065391600 @default.
• W2891243896 cites W2066848874 @default.
• W2891243896 cites W2075085561 @default.
• W2891243896 cites W2077943855 @default.
• W2891243896 cites W2080133581 @default.
• W2891243896 cites W2086080028 @default.
• W2891243896 cites W2086237189 @default.
• W2891243896 cites W2090056328 @default.
• W2891243896 cites W2090832661 @default.
• W2891243896 cites W2091007197 @default.
• W2891243896 cites W2091402383 @default.
• W2891243896 cites W2111359832 @default.
• W2891243896 cites W2111989793 @default.
• W2891243896 cites W2114681746 @default.
• W2891243896 cites W2121018683 @default.
• W2891243896 cites W2121965670 @default.
• W2891243896 cites W2126233407 @default.
• W2891243896 cites W2129957034 @default.
• W2891243896 cites W2135368430 @default.
• W2891243896 cites W2148680935 @default.
• W2891243896 cites W2153773787 @default.
• W2891243896 cites W2162532089 @default.
• W2891243896 cites W2162764250 @default.
• W2891243896 cites W2163677785 @default.
• W2891243896 cites W2168671325 @default.
• W2891243896 cites W2224588211 @default.
• W2891243896 cites W2335925695 @default.
• W2891243896 cites W2416236000 @default.
• W2891243896 cites W2493523341 @default.
• W2891243896 cites W2600140812 @default.
• W2891243896 cites W2606986150 @default.
• W2891243896 cites W2734911163 @default.
• W2891243896 cites W2775305270 @default.
• W2891243896 cites W2789366991 @default.
• W2891243896 cites W2808196202 @default.
• W2891243896 cites W4300534374 @default.
• W2891243896 doi "https://doi.org/10.3389/fgene.2018.00325" @default.
• W2891243896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139464" @default.
• W2891243896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250478" @default.
• W2891243896 hasPublicationYear "2018" @default.
• W2891243896 type Work @default.
• W2891243896 sameAs 2891243896 @default.
• W2891243896 citedByCount "24" @default.
• W2891243896 countsByYear W28912438962019 @default.
• W2891243896 countsByYear W28912438962020 @default.
• W2891243896 countsByYear W28912438962021 @default.
• W2891243896 countsByYear W28912438962022 @default.
• W2891243896 countsByYear W28912438962023 @default.
• W2891243896 crossrefType "journal-article" @default.
• W2891243896 hasAuthorship W2891243896A5003781135 @default.
• W2891243896 hasAuthorship W2891243896A5012159936 @default.
• W2891243896 hasAuthorship W2891243896A5015174459 @default.
• W2891243896 hasAuthorship W2891243896A5021540971 @default.
• W2891243896 hasAuthorship W2891243896A5027494117 @default.
• W2891243896 hasAuthorship W2891243896A5040874962 @default.
• W2891243896 hasAuthorship W2891243896A5041043150 @default.
• W2891243896 hasAuthorship W2891243896A5063560666 @default.
• W2891243896 hasBestOaLocation W28912438961 @default.

• next