Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891244102> ?p ?o ?g. }
- W2891244102 abstract "A bstract In eukaryotes, membrane contact sites (MCS) allow direct communication between organelles. Plants have evolved unique MCS, the plasmodesmata intercellular pores, which combine endoplasmic reticulum (ER) - plasma membrane (PM) contacts with regulation of cell-to-cell signalling. The molecular mechanism and function of membrane tethering within plasmodesmata remains unknown. Here we show that the Multiple C2 domains and Transmembrane region Protein (MCTP) family, key regulators of cell-to-cell signalling in plants, act as ER - PM tethers specifically at plasmodesmata. We report that MCTPs are core plasmodesmata proteins that insert into the ER via their transmembrane region whilst their C2 domains dock to the PM through interaction with anionic phospholipids. A mctp3/4 loss-of-function mutant induces plant developmental defects while MCTP4 expression in a yeast Δtether mutant partially restores ER-PM tethering. Our data suggest that MCTPs are unique membrane tethers controlling both ER-PM contacts and cell-cell signalling." @default.
- W2891244102 created "2018-09-27" @default.
- W2891244102 creator A5002803886 @default.
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- W2891244102 date "2018-09-23" @default.
- W2891244102 modified "2023-10-18" @default.
- W2891244102 title "Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata" @default.
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