FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891245360> ?p ?o ?g. }

• W2891245360 endingPage "103" @default.
• W2891245360 startingPage "93" @default.
• W2891245360 abstract "The PI3K/AKT/FOXO signaling pathway plays an important role in the survival, proliferation and apoptosis of tumor cells. The aim of the present study was to explore whether metformin could affect insulin-promoting cell growth by regulation of this pathway. Anaplastic thyroid cancer cells were treated with 0–60 mM metformin for 24, 48 and 72 h. Cell viability, morphology, apoptosis and migration were investigated by MTT assay, microscopy observation, AnexinV-PI and the wound healing assay, respectively. Expression levels of PI3K, AKT and FOXO1 were detected by RT-qPCR, and proteins phosphorylated levels were determined by ELISA. Metformin decreased cell viability and migration in a significant time-and dose-dependent manner, and induced apoptosis and morphological changes in the cells. RT-qPCR results showed that expression levels of PI3K, AKT and FOXO1 was inhibited by metformin (P < 0.05). However, there was no significant change in the expression level of AKT following metformin treatment for C643 cell line (P > 0.05). ELISA results showed that metformin treatment had no significant effects on the phosphorylated levels of PI3K, AKT and FOXO1 (P > 0.05). The downregulation of FOXO1 was intensified by metformin, but no increase in cell viability was observed following FOXO1 downregulation by metformin. However, the exact molecular mechanism of metformin on inhibition of the PI3K/AKT pathway and subsequent decrease in cell viability remains unclear and further studies are required for its clarification." @default.
• W2891245360 created "2018-09-27" @default.
• W2891245360 creator A5003559502 @default.
• W2891245360 creator A5057534597 @default.
• W2891245360 creator A5068895569 @default.
• W2891245360 creator A5072998744 @default.
• W2891245360 creator A5080500381 @default.
• W2891245360 date "2018-09-21" @default.
• W2891245360 modified "2023-10-16" @default.
• W2891245360 title "Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines" @default.
• W2891245360 cites W1774980042 @default.
• W2891245360 cites W1978119991 @default.
• W2891245360 cites W1978221635 @default.
• W2891245360 cites W2000047595 @default.
• W2891245360 cites W2009665800 @default.
• W2891245360 cites W2013374433 @default.
• W2891245360 cites W2019029568 @default.
• W2891245360 cites W2037406465 @default.
• W2891245360 cites W2037742862 @default.
• W2891245360 cites W2044251727 @default.
• W2891245360 cites W2044992554 @default.
• W2891245360 cites W2045070462 @default.
• W2891245360 cites W2049179297 @default.
• W2891245360 cites W2051397875 @default.
• W2891245360 cites W2072009397 @default.
• W2891245360 cites W2073183536 @default.
• W2891245360 cites W2077447792 @default.
• W2891245360 cites W2078190084 @default.
• W2891245360 cites W2093664485 @default.
• W2891245360 cites W2098563852 @default.
• W2891245360 cites W2105714711 @default.
• W2891245360 cites W2121225884 @default.
• W2891245360 cites W2124231104 @default.
• W2891245360 cites W2133098474 @default.
• W2891245360 cites W2138226825 @default.
• W2891245360 cites W2150597699 @default.
• W2891245360 cites W2156362708 @default.
• W2891245360 cites W2156563694 @default.
• W2891245360 cites W2157267807 @default.
• W2891245360 cites W2157612725 @default.
• W2891245360 cites W2161145604 @default.
• W2891245360 cites W2181408364 @default.
• W2891245360 cites W2191688351 @default.
• W2891245360 cites W2218128634 @default.
• W2891245360 cites W2268698715 @default.
• W2891245360 cites W2388163742 @default.
• W2891245360 cites W2548882933 @default.
• W2891245360 doi "https://doi.org/10.1007/s40199-018-0208-2" @default.
• W2891245360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279666" @default.
• W2891245360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30242671" @default.
• W2891245360 hasPublicationYear "2018" @default.
• W2891245360 type Work @default.
• W2891245360 sameAs 2891245360 @default.
• W2891245360 citedByCount "29" @default.
• W2891245360 countsByYear W28912453602019 @default.
• W2891245360 countsByYear W28912453602020 @default.
• W2891245360 countsByYear W28912453602021 @default.
• W2891245360 countsByYear W28912453602022 @default.
• W2891245360 countsByYear W28912453602023 @default.
• W2891245360 crossrefType "journal-article" @default.
• W2891245360 hasAuthorship W2891245360A5003559502 @default.
• W2891245360 hasAuthorship W2891245360A5057534597 @default.
• W2891245360 hasAuthorship W2891245360A5068895569 @default.
• W2891245360 hasAuthorship W2891245360A5072998744 @default.
• W2891245360 hasAuthorship W2891245360A5080500381 @default.
• W2891245360 hasBestOaLocation W28912453602 @default.
• W2891245360 hasConcept C104317684 @default.
• W2891245360 hasConcept C121608353 @default.
• W2891245360 hasConcept C126322002 @default.
• W2891245360 hasConcept C127561419 @default.
• W2891245360 hasConcept C134018914 @default.
• W2891245360 hasConcept C140149449 @default.
• W2891245360 hasConcept C185592680 @default.
• W2891245360 hasConcept C190283241 @default.
• W2891245360 hasConcept C2779306644 @default.
• W2891245360 hasConcept C2779761222 @default.
• W2891245360 hasConcept C2780256643 @default.
• W2891245360 hasConcept C2780323712 @default.
• W2891245360 hasConcept C2780783641 @default.
• W2891245360 hasConcept C502942594 @default.
• W2891245360 hasConcept C53227056 @default.
• W2891245360 hasConcept C55493867 @default.
• W2891245360 hasConcept C62112901 @default.
• W2891245360 hasConcept C71924100 @default.
• W2891245360 hasConcept C75217442 @default.
• W2891245360 hasConcept C86554907 @default.
• W2891245360 hasConceptScore W2891245360C104317684 @default.
• W2891245360 hasConceptScore W2891245360C121608353 @default.
• W2891245360 hasConceptScore W2891245360C126322002 @default.
• W2891245360 hasConceptScore W2891245360C127561419 @default.
• W2891245360 hasConceptScore W2891245360C134018914 @default.
• W2891245360 hasConceptScore W2891245360C140149449 @default.
• W2891245360 hasConceptScore W2891245360C185592680 @default.
• W2891245360 hasConceptScore W2891245360C190283241 @default.
• W2891245360 hasConceptScore W2891245360C2779306644 @default.
• W2891245360 hasConceptScore W2891245360C2779761222 @default.
• W2891245360 hasConceptScore W2891245360C2780256643 @default.
• W2891245360 hasConceptScore W2891245360C2780323712 @default.

• next