Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891255590> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2891255590 endingPage "1682" @default.
- W2891255590 startingPage "1677" @default.
- W2891255590 abstract "Overlap syndrome (OS) describes the association of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) in a single individual. Subjects with OS have increased cardiovascular mortality which is presumed to be inflammation-mediated. As a clinical biomarker, an increased neutrophil count correlates with the severity of coronary artery stenosis.As little is known about the role of neutrophils in the underlying inflammatory mechanisms in OS, we aimed to assess the percentage of peripheral neutrophils (PPN) in OS vs in COPD alone.A cross-sectional study of patients with COPD and severe comorbidities, as defined by a Care Assessment Need score over 95, were seen in the Pulmonary Tele-Health Clinic at the Salem Veteran Affairs Medical Center, USA, over a 1-year period. Demographic and polysomnographic data, FEV1 and the Charlson Comorbidity Index (CCI) were extracted from the Electronic Medical Records. Obstructive sleep apnea was defined according to the American Academy of Sleep Medicine (AASM) guidelines. Serum inflammatory markers (PPN, CRP, fibrinogen and procalcitonin) were obtained after the Tele-Health appointment.Out of the 38 subjects with COPD, 17 (44%) had OS. Compliance with continuous positive airway pressure therapy (CPAP) was excellent in 7 OS subjects (41%). There was a significant difference in the PPN of subjects with OS vs COPD alone, regardless of whether they were compliant (p = 0.03) with the CPAP therapy or not (p = 0.005). No differences in the severity of COPD, baseline comorbidity, smoking, or inflammatory markers were found between the OS and COPD-only subjects. Body mass index (BMI), COPD severity, smoking, and home oxygen therapy (HOT) use were not associated with PPN (p > 0.2).Overlap syndrome subjects have higher PPN than those with COPD alone, regardless of their CPAP compliance. Our results could be used to motivate OS subjects to improve their lifestyles and to comply with drug therapies aimed at reducing cardiovascular disease (CVD)." @default.
- W2891255590 created "2018-09-27" @default.
- W2891255590 creator A5047704809 @default.
- W2891255590 creator A5052574584 @default.
- W2891255590 creator A5062439836 @default.
- W2891255590 creator A5082321021 @default.
- W2891255590 date "2018-08-07" @default.
- W2891255590 modified "2023-09-25" @default.
- W2891255590 title "The peripheral neutrophils in subjects with COPD-OSA overlap syndrome and severe comorbidities: A feasible inflammatory biomarker?" @default.
- W2891255590 cites W2121615890 @default.
- W2891255590 doi "https://doi.org/10.17219/acem/75904" @default.
- W2891255590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30085419" @default.
- W2891255590 hasPublicationYear "2018" @default.
- W2891255590 type Work @default.
- W2891255590 sameAs 2891255590 @default.
- W2891255590 citedByCount "7" @default.
- W2891255590 countsByYear W28912555902020 @default.
- W2891255590 countsByYear W28912555902021 @default.
- W2891255590 countsByYear W28912555902022 @default.
- W2891255590 countsByYear W28912555902023 @default.
- W2891255590 crossrefType "journal-article" @default.
- W2891255590 hasAuthorship W2891255590A5047704809 @default.
- W2891255590 hasAuthorship W2891255590A5052574584 @default.
- W2891255590 hasAuthorship W2891255590A5062439836 @default.
- W2891255590 hasAuthorship W2891255590A5082321021 @default.
- W2891255590 hasBestOaLocation W28912555901 @default.
- W2891255590 hasConcept C10936531 @default.
- W2891255590 hasConcept C126322002 @default.
- W2891255590 hasConcept C164705383 @default.
- W2891255590 hasConcept C185592680 @default.
- W2891255590 hasConcept C1862650 @default.
- W2891255590 hasConcept C2775941666 @default.
- W2891255590 hasConcept C2776006263 @default.
- W2891255590 hasConcept C2776780178 @default.
- W2891255590 hasConcept C2777935920 @default.
- W2891255590 hasConcept C2778205975 @default.
- W2891255590 hasConcept C2778384902 @default.
- W2891255590 hasConcept C2779159551 @default.
- W2891255590 hasConcept C2779547634 @default.
- W2891255590 hasConcept C2780221984 @default.
- W2891255590 hasConcept C2780322006 @default.
- W2891255590 hasConcept C2781197716 @default.
- W2891255590 hasConcept C2781326671 @default.
- W2891255590 hasConcept C55493867 @default.
- W2891255590 hasConcept C71924100 @default.
- W2891255590 hasConceptScore W2891255590C10936531 @default.
- W2891255590 hasConceptScore W2891255590C126322002 @default.
- W2891255590 hasConceptScore W2891255590C164705383 @default.
- W2891255590 hasConceptScore W2891255590C185592680 @default.
- W2891255590 hasConceptScore W2891255590C1862650 @default.
- W2891255590 hasConceptScore W2891255590C2775941666 @default.
- W2891255590 hasConceptScore W2891255590C2776006263 @default.
- W2891255590 hasConceptScore W2891255590C2776780178 @default.
- W2891255590 hasConceptScore W2891255590C2777935920 @default.
- W2891255590 hasConceptScore W2891255590C2778205975 @default.
- W2891255590 hasConceptScore W2891255590C2778384902 @default.
- W2891255590 hasConceptScore W2891255590C2779159551 @default.
- W2891255590 hasConceptScore W2891255590C2779547634 @default.
- W2891255590 hasConceptScore W2891255590C2780221984 @default.
- W2891255590 hasConceptScore W2891255590C2780322006 @default.
- W2891255590 hasConceptScore W2891255590C2781197716 @default.
- W2891255590 hasConceptScore W2891255590C2781326671 @default.
- W2891255590 hasConceptScore W2891255590C55493867 @default.
- W2891255590 hasConceptScore W2891255590C71924100 @default.
- W2891255590 hasIssue "12" @default.
- W2891255590 hasLocation W28912555901 @default.
- W2891255590 hasLocation W28912555902 @default.
- W2891255590 hasLocation W28912555903 @default.
- W2891255590 hasOpenAccess W2891255590 @default.
- W2891255590 hasPrimaryLocation W28912555901 @default.
- W2891255590 hasRelatedWork W17905005 @default.
- W2891255590 hasRelatedWork W2130008215 @default.
- W2891255590 hasRelatedWork W3147276477 @default.
- W2891255590 hasRelatedWork W3158749872 @default.
- W2891255590 hasRelatedWork W325940945 @default.
- W2891255590 hasRelatedWork W4240217169 @default.
- W2891255590 hasRelatedWork W4280499426 @default.
- W2891255590 hasRelatedWork W4282030331 @default.
- W2891255590 hasRelatedWork W4294091336 @default.
- W2891255590 hasRelatedWork W4379878163 @default.
- W2891255590 hasVolume "27" @default.
- W2891255590 isParatext "false" @default.
- W2891255590 isRetracted "false" @default.
- W2891255590 magId "2891255590" @default.
- W2891255590 workType "article" @default.