FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891260064> ?p ?o ?g. }

• W2891260064 abstract "e18539 Background: The pathophysiology of acute skin graft versus host disease (asGVHD) is thought to be initiated when donor T cells encounter recipient dendritic cells (DC) and become activated. Studies have shown that vitamin D (VD) inhibits DC maturation, polarizes T cell populations toward Th2 cytokine phenotype, And biases toward tolerating T cell populations. We analyzed pre-SCT serum vitamin D levels and sought to determine an association with development of acute skin GVHD. Methods: 154 patients, with matched SCT at UTSW Medical Center from December 2007 to December 2014, and who had serum samples banked prior to conditioning were included in the analysis. Pertinent data were extracted from the UTSW BMT database and EMR. Serum samples collected 1-3 months prior to SCT were used to detect 25-hydroxyvitamin D (VD) concentrations. Cumulative incidence (CI) of asGVHD grade II-IV were assessed within 100 days post-SCT. A significantl difference (p-value = 0.026, Breslow-Day test) in the associations between Vit D and asGVHD for patients under RIC and ABLgroups was present, so we analyzed the primary endpoint, time to asGVHD since SCT, separately among two these 2 groups. CI functions were constructed with death and relapse as competing risks. Results: Out of 154 patients, 93 were male, mean age was 51, range 20-72 and median VD was 21 ng/ml (range 7.1-63.3). There were 112 patients with VD < 25 ng/mL (VD < 25) and 41 with VD ≥ 25 ng/mL (VD≥25). Age, conditioning regimen, donor type, cell source, ABO compatibility, GVHD prophylaxis were similar in both groups. Overall CI asGVHD was 24%. CI of asGVHD was 23.8% in VD≥25 and 24.1% in VD < 25. Patients were then analyzed separately with respect to type of conditioning regimen they received (Ablative (ABL) vs Reducing intensity (RIC)). Figure 1A shows that in the ABL group the CI of asGVHD appears increased in patient with VitD≥25 (40% vs 27.1%, p = 0.27). In contrast, Figure 1B shows that in RIC group the CI of asGVHD is higher for those with VD < 25 (4.8% vs 24.1% , p = 0.05). Conclusions: After accounting for competing factors, KM analysis in the RIC group showed that patients with VD level < 25 ng/mL were at a higher risk of developing asGVHD. Further studies to clarify the association between VD status and development of asGVHD are warranted." @default.
• W2891260064 created "2018-09-27" @default.
• W2891260064 creator A5003020353 @default.
• W2891260064 creator A5012640360 @default.
• W2891260064 creator A5014294667 @default.
• W2891260064 creator A5017032740 @default.
• W2891260064 creator A5036043599 @default.
• W2891260064 creator A5039481107 @default.
• W2891260064 creator A5062987674 @default.
• W2891260064 date "2017-05-20" @default.
• W2891260064 modified "2023-10-15" @default.
• W2891260064 title "Association of pre-allogeneic hematopoietic stem cell transplant 25-hydroxy-vitamin D level and development of acute skin graft-versus-host-disease: A retrospective analysis of 154 patients." @default.
• W2891260064 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e18539" @default.
• W2891260064 hasPublicationYear "2017" @default.
• W2891260064 type Work @default.
• W2891260064 sameAs 2891260064 @default.
• W2891260064 citedByCount "1" @default.
• W2891260064 countsByYear W28912600642020 @default.
• W2891260064 crossrefType "journal-article" @default.
• W2891260064 hasAuthorship W2891260064A5003020353 @default.
• W2891260064 hasAuthorship W2891260064A5012640360 @default.
• W2891260064 hasAuthorship W2891260064A5014294667 @default.
• W2891260064 hasAuthorship W2891260064A5017032740 @default.
• W2891260064 hasAuthorship W2891260064A5036043599 @default.
• W2891260064 hasAuthorship W2891260064A5039481107 @default.
• W2891260064 hasAuthorship W2891260064A5062987674 @default.
• W2891260064 hasConcept C109159458 @default.
• W2891260064 hasConcept C126322002 @default.
• W2891260064 hasConcept C141071460 @default.
• W2891260064 hasConcept C143998085 @default.
• W2891260064 hasConcept C167135981 @default.
• W2891260064 hasConcept C203014093 @default.
• W2891260064 hasConcept C2776940978 @default.
• W2891260064 hasConcept C2777408962 @default.
• W2891260064 hasConcept C2778086970 @default.
• W2891260064 hasConcept C2779134260 @default.
• W2891260064 hasConcept C2779972918 @default.
• W2891260064 hasConcept C28328180 @default.
• W2891260064 hasConcept C54355233 @default.
• W2891260064 hasConcept C71924100 @default.
• W2891260064 hasConcept C86803240 @default.
• W2891260064 hasConcept C90924648 @default.
• W2891260064 hasConceptScore W2891260064C109159458 @default.
• W2891260064 hasConceptScore W2891260064C126322002 @default.
• W2891260064 hasConceptScore W2891260064C141071460 @default.
• W2891260064 hasConceptScore W2891260064C143998085 @default.
• W2891260064 hasConceptScore W2891260064C167135981 @default.
• W2891260064 hasConceptScore W2891260064C203014093 @default.
• W2891260064 hasConceptScore W2891260064C2776940978 @default.
• W2891260064 hasConceptScore W2891260064C2777408962 @default.
• W2891260064 hasConceptScore W2891260064C2778086970 @default.
• W2891260064 hasConceptScore W2891260064C2779134260 @default.
• W2891260064 hasConceptScore W2891260064C2779972918 @default.
• W2891260064 hasConceptScore W2891260064C28328180 @default.
• W2891260064 hasConceptScore W2891260064C54355233 @default.
• W2891260064 hasConceptScore W2891260064C71924100 @default.
• W2891260064 hasConceptScore W2891260064C86803240 @default.
• W2891260064 hasConceptScore W2891260064C90924648 @default.
• W2891260064 hasLocation W28912600641 @default.
• W2891260064 hasOpenAccess W2891260064 @default.
• W2891260064 hasPrimaryLocation W28912600641 @default.
• W2891260064 hasRelatedWork W1994399593 @default.
• W2891260064 hasRelatedWork W2032239792 @default.
• W2891260064 hasRelatedWork W2078689464 @default.
• W2891260064 hasRelatedWork W2128736934 @default.
• W2891260064 hasRelatedWork W2290195184 @default.
• W2891260064 hasRelatedWork W2325491825 @default.
• W2891260064 hasRelatedWork W2551897113 @default.
• W2891260064 hasRelatedWork W2568997719 @default.
• W2891260064 hasRelatedWork W2888102499 @default.
• W2891260064 hasRelatedWork W2897473764 @default.
• W2891260064 hasRelatedWork W2920868324 @default.
• W2891260064 hasRelatedWork W2947426064 @default.
• W2891260064 hasRelatedWork W2952801151 @default.
• W2891260064 hasRelatedWork W2979430400 @default.
• W2891260064 hasRelatedWork W2980741056 @default.
• W2891260064 hasRelatedWork W3103344060 @default.
• W2891260064 hasRelatedWork W3204847457 @default.
• W2891260064 hasRelatedWork W3213272240 @default.
• W2891260064 hasRelatedWork W658212748 @default.
• W2891260064 hasRelatedWork W2780056515 @default.
• W2891260064 isParatext "false" @default.
• W2891260064 isRetracted "false" @default.
• W2891260064 magId "2891260064" @default.
• W2891260064 workType "article" @default.