FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891272355> ?p ?o ?g. }

• W2891272355 abstract "Abstract Human RecQL4 helicase plays critical roles in the maintenance of genomic stability. Mutations in RecQL4 helicase results in three clinically related autosomal recessive disorders: Rothmund–Thomson syndrome (RTS), RAPADILINO, and Baller–Gerold syndrome. In addition to several premature aging features, RTS patients are characterized by aneuploidy involving either loss or gain of a single chromosome. Chromosome mosaicism and isochromosomes involving chromosomes 2, 7, and 8 have been reported in RecQL4-deficient RTS patients, but the precise role of RecQL4 in chromosome segregation/stability remains to be elucidated. Here, we demonstrate that RecQL4 physically and functionally interacts with Aurora B kinase (AURKB) and stabilizes its expression by inhibiting its ubiquitination process. Our study indicates that the N-terminus of RecQL4 interacts with the catalytic domain of AURKB. Strikingly, RecQL4 suppression reduces the expression of AURKB leading to mitotic irregularities and apoptotic cell death. RecQL4 suppression increases the proportion of cells at the G2/M phase followed by an extensive cell death, presumably owing to the accumulation of mitotic irregularities. Both these defects (accumulation of cells at G2/M phase and an improper mitotic exit to sub-G1) are complemented by the ectopic expression of AURKB. Finally, evidence is provided for the requirement of both human telomerase reverse transcriptase and RecQL4 for stable immortalization and longevity of RTS fibroblasts. Collectively, our study suggests that the RecQL4–AURKB axis is essential for cellular proliferation, cell cycle progression, and mitotic stability in human cells." @default.
• W2891272355 created "2018-09-27" @default.
• W2891272355 creator A5003163815 @default.
• W2891272355 creator A5008585958 @default.
• W2891272355 creator A5018416841 @default.
• W2891272355 creator A5022424817 @default.
• W2891272355 creator A5025940124 @default.
• W2891272355 creator A5037645003 @default.
• W2891272355 creator A5056875039 @default.
• W2891272355 creator A5064403857 @default.
• W2891272355 creator A5073588989 @default.
• W2891272355 creator A5080562594 @default.
• W2891272355 creator A5082974417 @default.
• W2891272355 date "2018-09-12" @default.
• W2891272355 modified "2023-10-12" @default.
• W2891272355 title "RecQL4-Aurora B kinase axis is essential for cellular proliferation, cell cycle progression, and mitotic integrity" @default.
• W2891272355 cites W1273150541 @default.
• W2891272355 cites W1601758486 @default.
• W2891272355 cites W1629666474 @default.
• W2891272355 cites W1935801587 @default.
• W2891272355 cites W1987118575 @default.
• W2891272355 cites W1989109526 @default.
• W2891272355 cites W1997732163 @default.
• W2891272355 cites W1997963513 @default.
• W2891272355 cites W1998022608 @default.
• W2891272355 cites W2005962907 @default.
• W2891272355 cites W2007336719 @default.
• W2891272355 cites W2010328673 @default.
• W2891272355 cites W2019698837 @default.
• W2891272355 cites W2022597841 @default.
• W2891272355 cites W2027315326 @default.
• W2891272355 cites W2027974435 @default.
• W2891272355 cites W2038433639 @default.
• W2891272355 cites W2039142844 @default.
• W2891272355 cites W2040478292 @default.
• W2891272355 cites W2050723856 @default.
• W2891272355 cites W2055477411 @default.
• W2891272355 cites W2060329343 @default.
• W2891272355 cites W2062113330 @default.
• W2891272355 cites W2069923008 @default.
• W2891272355 cites W2079302097 @default.
• W2891272355 cites W2093508765 @default.
• W2891272355 cites W2096250900 @default.
• W2891272355 cites W2096634902 @default.
• W2891272355 cites W2097763610 @default.
• W2891272355 cites W2101022917 @default.
• W2891272355 cites W2101450743 @default.
• W2891272355 cites W2107201644 @default.
• W2891272355 cites W2123641636 @default.
• W2891272355 cites W2126192932 @default.
• W2891272355 cites W2130746121 @default.
• W2891272355 cites W2131638601 @default.
• W2891272355 cites W2134873595 @default.
• W2891272355 cites W2147161817 @default.
• W2891272355 cites W2161959295 @default.
• W2891272355 cites W2164530696 @default.
• W2891272355 cites W2170910759 @default.
• W2891272355 cites W2171193478 @default.
• W2891272355 cites W2308504656 @default.
• W2891272355 cites W2731832291 @default.
• W2891272355 cites W2773508959 @default.
• W2891272355 doi "https://doi.org/10.1038/s41389-018-0080-4" @default.
• W2891272355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6134139" @default.
• W2891272355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206236" @default.
• W2891272355 hasPublicationYear "2018" @default.
• W2891272355 type Work @default.
• W2891272355 sameAs 2891272355 @default.
• W2891272355 citedByCount "21" @default.
• W2891272355 countsByYear W28912723552019 @default.
• W2891272355 countsByYear W28912723552020 @default.
• W2891272355 countsByYear W28912723552021 @default.
• W2891272355 countsByYear W28912723552022 @default.
• W2891272355 countsByYear W28912723552023 @default.
• W2891272355 crossrefType "journal-article" @default.
• W2891272355 hasAuthorship W2891272355A5003163815 @default.
• W2891272355 hasAuthorship W2891272355A5008585958 @default.
• W2891272355 hasAuthorship W2891272355A5018416841 @default.
• W2891272355 hasAuthorship W2891272355A5022424817 @default.
• W2891272355 hasAuthorship W2891272355A5025940124 @default.
• W2891272355 hasAuthorship W2891272355A5037645003 @default.
• W2891272355 hasAuthorship W2891272355A5056875039 @default.
• W2891272355 hasAuthorship W2891272355A5064403857 @default.
• W2891272355 hasAuthorship W2891272355A5073588989 @default.
• W2891272355 hasAuthorship W2891272355A5080562594 @default.
• W2891272355 hasAuthorship W2891272355A5082974417 @default.
• W2891272355 hasBestOaLocation W28912723551 @default.
• W2891272355 hasConcept C104317684 @default.
• W2891272355 hasConcept C140752955 @default.
• W2891272355 hasConcept C143425029 @default.
• W2891272355 hasConcept C146276462 @default.
• W2891272355 hasConcept C1491633281 @default.
• W2891272355 hasConcept C161223559 @default.
• W2891272355 hasConcept C175732170 @default.
• W2891272355 hasConcept C178169997 @default.
• W2891272355 hasConcept C2778354886 @default.
• W2891272355 hasConcept C29537977 @default.
• W2891272355 hasConcept C30481170 @default.
• W2891272355 hasConcept C47432576 @default.
• W2891272355 hasConcept C502942594 @default.
• W2891272355 hasConcept C54355233 @default.

• next