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• W2891272445 endingPage "3294" @default.
• W2891272445 startingPage "3294" @default.
• W2891272445 abstract "Given that human amniotic membrane is a valuable biological material not readily available for corneal epithelial tissue engineering, gelatin is considered as a potential alternative to construct a cellular microenvironment. This study investigates, for the first time, the influence of cross-linking density of carbodiimide-treated gelatin matrices on the structures and properties of artificial limbal stem cell niches. Our results showed that an increase in the carbodiimide concentration from 1.5 to 15 mM leads to an upward trend in the structural and suture strength of biopolymers. Furthermore, increasing number of cross-linking bridges capable of linking protein molecules together may reduce their crystallinity. For the samples treated with 50 mM of cross-linker (i.e., the presence of excess N-substituted carbodiimide), abundant N-acylurea was detected, which was detrimental to the in vitro and in vivo ocular biocompatibility of gelatin matrices. Surface roughness and stiffness of biopolymer substrates were found to be positively correlated with carbodiimide-induced cross-link formation. Significant increases of integrin β1 expression, metabolic activity, and ABCG2 expression were noted as the cross-linker concentration increased, suggesting that the bulk crystalline structure and surface roughness/stiffness of niche attributed to the number of cross-linking bridges may have profound effects on a variety of limbal epithelial cell behaviors, including adhesion, proliferation, and stemness maintenance. In summary, taking the advantages of carbodiimide cross-linking-mediated development of gelatin matrices, new niches with tunable cross-linking densities can provide a significant boost to maintain the limbal stem cells during ex vivo expansion." @default.
• W2891272445 created "2018-09-27" @default.
• W2891272445 creator A5006317320 @default.
• W2891272445 creator A5055735453 @default.
• W2891272445 creator A5083623112 @default.
• W2891272445 date "2018-10-23" @default.
• W2891272445 modified "2023-09-28" @default.
• W2891272445 title "Effect of Cross-Linking Density on the Structures and Properties of Carbodiimide-Treated Gelatin Matrices as Limbal Stem Cell Niches" @default.
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• W2891272445 doi "https://doi.org/10.3390/ijms19113294" @default.
• W2891272445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6274912" @default.
• W2891272445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30360558" @default.
• W2891272445 hasPublicationYear "2018" @default.
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• W2891272445 hasAuthorship W2891272445A5083623112 @default.

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