FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891272832> ?p ?o ?g. }

• W2891272832 abstract "There is evidence that the neural response to increasing working memory (WM) load is modulated by age and performance level. For a valid interpretation of these effects, however, it is important to understand, whether and how they are related to grey matter atrophy. In the current work, we therefore used functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM) to examine the association between age, performance level, spatial WM load-related brain activation and grey matter volume in 18 younger high-performers (YHP), 17 younger low-performers (YLP), 17 older high-performers (OHP), and 18 older low-performers (OLP). In multiple sub regions of the prefrontal cortex (PFC), load-related activation followed a linear trend with increasing activation at increasing load in all experimental groups. Results did not reveal differences between the sub groups. Particularly, older adults additionally showed a pattern of increasing activation from low to medium load but stable or even decreasing activation from medium to high load in other sub regions of the PFC (quadratic trend). Quadratic trend related brain activation was higher in older than in younger adults and in OLP compared to OHP. In OLP, quadratic trend related brain activation was negatively correlated with both performance accuracy and prefrontal grey matter volume. The results suggest an efficient upregulation of multiple PFC areas as response to increasing WM load in younger and older adults. Older adults and particularly OLP additionally show dysfunctional response patterns (i.e. enhanced quadratic trend related brain activation compared to younger adults and OHP, respectively) in other PFC clusters being associated with grey matter atrophy." @default.
• W2891272832 created "2018-09-27" @default.
• W2891272832 creator A5015396265 @default.
• W2891272832 creator A5064145500 @default.
• W2891272832 creator A5072585260 @default.
• W2891272832 date "2018-09-11" @default.
• W2891272832 modified "2023-09-25" @default.
• W2891272832 title "Performance Level and Cortical Atrophy Modulate the Neural Response to Increasing Working Memory Load in Younger and Older Adults" @default.
• W2891272832 cites W1899170688 @default.
• W2891272832 cites W1915538384 @default.
• W2891272832 cites W1929729372 @default.
• W2891272832 cites W1935820406 @default.
• W2891272832 cites W1963663815 @default.
• W2891272832 cites W1981186475 @default.
• W2891272832 cites W1983728847 @default.
• W2891272832 cites W1997538961 @default.
• W2891272832 cites W2000028336 @default.
• W2891272832 cites W2011702562 @default.
• W2891272832 cites W2012437345 @default.
• W2891272832 cites W2016068952 @default.
• W2891272832 cites W2020031936 @default.
• W2891272832 cites W2021289805 @default.
• W2891272832 cites W2023436080 @default.
• W2891272832 cites W2037395966 @default.
• W2891272832 cites W2040041725 @default.
• W2891272832 cites W2042974739 @default.
• W2891272832 cites W2049546272 @default.
• W2891272832 cites W2049799256 @default.
• W2891272832 cites W2052590556 @default.
• W2891272832 cites W2058046532 @default.
• W2891272832 cites W2060751477 @default.
• W2891272832 cites W2061195971 @default.
• W2891272832 cites W2062499611 @default.
• W2891272832 cites W2064375712 @default.
• W2891272832 cites W2070083158 @default.
• W2891272832 cites W2070869229 @default.
• W2891272832 cites W2073850739 @default.
• W2891272832 cites W2076284955 @default.
• W2891272832 cites W2078790263 @default.
• W2891272832 cites W2086667674 @default.
• W2891272832 cites W2089725106 @default.
• W2891272832 cites W2094788831 @default.
• W2891272832 cites W2095882961 @default.
• W2891272832 cites W2103069600 @default.
• W2891272832 cites W2105250545 @default.
• W2891272832 cites W2105306137 @default.
• W2891272832 cites W2109845730 @default.
• W2891272832 cites W2111464173 @default.
• W2891272832 cites W2118421222 @default.
• W2891272832 cites W2119202243 @default.
• W2891272832 cites W2119822089 @default.
• W2891272832 cites W2122328387 @default.
• W2891272832 cites W2123973918 @default.
• W2891272832 cites W2124648012 @default.
• W2891272832 cites W2129965408 @default.
• W2891272832 cites W2131557760 @default.
• W2891272832 cites W2139581313 @default.
• W2891272832 cites W2142717706 @default.
• W2891272832 cites W2146118786 @default.
• W2891272832 cites W2147597108 @default.
• W2891272832 cites W2149621887 @default.
• W2891272832 cites W2151176001 @default.
• W2891272832 cites W2154653178 @default.
• W2891272832 cites W2155419569 @default.
• W2891272832 cites W2158069208 @default.
• W2891272832 cites W2159465690 @default.
• W2891272832 cites W2159872566 @default.
• W2891272832 cites W2161220328 @default.
• W2891272832 cites W2165758561 @default.
• W2891272832 cites W2167702959 @default.
• W2891272832 cites W2171776652 @default.
• W2891272832 cites W2515834816 @default.
• W2891272832 cites W2736468715 @default.
• W2891272832 cites W2743773590 @default.
• W2891272832 cites W2745105350 @default.
• W2891272832 cites W4294557829 @default.
• W2891272832 cites W4376849352 @default.
• W2891272832 cites W753595173 @default.
• W2891272832 doi "https://doi.org/10.3389/fnagi.2018.00265" @default.
• W2891272832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141635" @default.
• W2891272832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30254582" @default.
• W2891272832 hasPublicationYear "2018" @default.
• W2891272832 type Work @default.
• W2891272832 sameAs 2891272832 @default.
• W2891272832 citedByCount "5" @default.
• W2891272832 countsByYear W28912728322021 @default.
• W2891272832 countsByYear W28912728322022 @default.
• W2891272832 crossrefType "journal-article" @default.
• W2891272832 hasAuthorship W2891272832A5015396265 @default.
• W2891272832 hasAuthorship W2891272832A5064145500 @default.
• W2891272832 hasAuthorship W2891272832A5072585260 @default.
• W2891272832 hasBestOaLocation W28912728321 @default.
• W2891272832 hasConcept C126322002 @default.
• W2891272832 hasConcept C126838900 @default.
• W2891272832 hasConcept C129564537 @default.
• W2891272832 hasConcept C138496976 @default.
• W2891272832 hasConcept C143409427 @default.
• W2891272832 hasConcept C15744967 @default.
• W2891272832 hasConcept C169760540 @default.
• W2891272832 hasConcept C169900460 @default.

• next