Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891275263> ?p ?o ?g. }
- W2891275263 abstract "Human noroviruses are a leading cause of gastroenteritis throughout the world but are challenging to study in vivo and in vitro . Murine norovirus (MNoV) provides a tractable genetic and small-animal model to study norovirus biology and immune responses. Interferons are critical mediators of antiviral immunity, but excessive expression can dysregulate the immune system. IFN-λ plays an important role at mucosal surfaces, including the gastrointestinal tract, and both IFN-λ and commensal enteric bacteria are important modulators of persistent MNoV infection. LUBAC, of which HOIL1 is a component, is reported to inhibit type I IFN induction after RIG-I stimulation. We show, in contrast, that HOIL1 is critical for type I and III IFN induction during infection with MNoV, a virus that preferentially activates MDA5. Moreover, HOIL1 regulates MNoV infection in vivo . These data reveal distinct functions for LUBAC in these closely related signaling pathways and in modulation of IFN expression." @default.
- W2891275263 created "2018-09-27" @default.
- W2891275263 creator A5002593635 @default.
- W2891275263 creator A5010638373 @default.
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- W2891275263 creator A5054805394 @default.
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- W2891275263 creator A5077816182 @default.
- W2891275263 creator A5080025965 @default.
- W2891275263 creator A5081667704 @default.
- W2891275263 date "2018-12-01" @default.
- W2891275263 modified "2023-10-18" @default.
- W2891275263 title "HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection" @default.
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