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• W2891282544 abstract "Background The European Chemical Agency (ECHA) definition of prolonged contact was introduced in 2014 and has not been evaluated clinically. Objectives To assess whether nickel‐sensitized individuals react on patch testing with high nickel‐releasing metal discs for short and repetitive periods. Materials and methods We patch tested 45 nickel‐sensitized individuals double‐blind with 2 different types of high nickel‐releasing discs for 10, 30 and 60 minutes on 3 occasions over a period of 2 weeks, and for 1 longer period. Discs were tested for nickel release. Results Nickel release from both discs significantly exceeded the 0.5 μg Ni/cm 2 /week limit of the EU REACH nickel restriction. However, only 1 individual tested had a largely dose‐dependent allergic reaction. Conclusions The majority of nickel‐allergic subjects did not react to nickel discs after 2 hours or after repetitive exposures of up to 30 minutes on 3 occasions over a period of 2 weeks. The length of time needed to cause nickel allergic contact dermatitis in most nickel‐allergic individuals is longer than the ECHA guidance definition. Longer test times are needed to define the time required to cause dermatitis in most nickel‐allergic individuals. As a limitation, the test conditions did not adequately assess real‐life factors such as friction, which is relevant for some uses of nickel." @default.
• W2891282544 created "2018-09-27" @default.
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• W2891282544 date "2018-09-14" @default.
• W2891282544 modified "2023-09-26" @default.
• W2891282544 title "Does clinical testing support the current guidance definition of prolonged contact for nickel allergy?" @default.
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• W2891282544 doi "https://doi.org/10.1111/cod.13095" @default.
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