Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891282659> ?p ?o ?g. }
- W2891282659 abstract "Altered cellular biomechanics have been implicated as key photogenic triggers in age-related diseases. An aberrant liquid-to-solid phase transition, observed in in vitro reconstituted droplets of FUS protein, has been recently proposed as a possible pathogenic mechanism for amyotrophic lateral sclerosis (ALS). Whether such transition occurs in cell environments is currently unknown as a consequence of the limited measuring capability of the existing techniques, which are invasive or lack of subcellular resolution. Here we developed a non-contact and label-free imaging method, named background-deflection Brillouin microscopy, to investigate the three-dimensional intracellular biomechanics at a sub-micron resolution. Our method exploits diffraction to achieve an unprecedented 10,000-fold enhancement in the spectral contrast of single-stage spectrometers, enabling, to the best of our knowledge, the first direct biomechanical analysis on intracellular stress granules containing ALS mutant FUS protein in fixed cells. Our findings provide fundamental insights on the critical aggregation step underlying the neurodegenerative ALS disease." @default.
- W2891282659 created "2018-09-27" @default.
- W2891282659 creator A5008748795 @default.
- W2891282659 creator A5031776025 @default.
- W2891282659 creator A5035182510 @default.
- W2891282659 creator A5091068908 @default.
- W2891282659 date "2018-09-10" @default.
- W2891282659 modified "2023-09-29" @default.
- W2891282659 title "Background-deflection Brillouin microscopy reveals altered biomechanics of intracellular stress granules by ALS protein FUS" @default.
- W2891282659 cites W1522224474 @default.
- W2891282659 cites W1952608303 @default.
- W2891282659 cites W1966641221 @default.
- W2891282659 cites W1967151510 @default.
- W2891282659 cites W1969408393 @default.
- W2891282659 cites W1969583173 @default.
- W2891282659 cites W1974915238 @default.
- W2891282659 cites W1975553175 @default.
- W2891282659 cites W1981131286 @default.
- W2891282659 cites W1986349994 @default.
- W2891282659 cites W1987055540 @default.
- W2891282659 cites W1992221541 @default.
- W2891282659 cites W1996706767 @default.
- W2891282659 cites W2000442023 @default.
- W2891282659 cites W2006034599 @default.
- W2891282659 cites W2010680035 @default.
- W2891282659 cites W2018342523 @default.
- W2891282659 cites W2024377496 @default.
- W2891282659 cites W2025379668 @default.
- W2891282659 cites W2075503273 @default.
- W2891282659 cites W2077670953 @default.
- W2891282659 cites W2078068604 @default.
- W2891282659 cites W2089725314 @default.
- W2891282659 cites W2105238700 @default.
- W2891282659 cites W2121136141 @default.
- W2891282659 cites W2121908250 @default.
- W2891282659 cites W2123396611 @default.
- W2891282659 cites W2127515106 @default.
- W2891282659 cites W2143069387 @default.
- W2891282659 cites W2148356422 @default.
- W2891282659 cites W2156440487 @default.
- W2891282659 cites W2161346554 @default.
- W2891282659 cites W2166315184 @default.
- W2891282659 cites W2168958678 @default.
- W2891282659 cites W2169969818 @default.
- W2891282659 cites W2233029974 @default.
- W2891282659 cites W2261446665 @default.
- W2891282659 cites W2335996666 @default.
- W2891282659 cites W2464346210 @default.
- W2891282659 cites W2549986730 @default.
- W2891282659 cites W2553996574 @default.
- W2891282659 cites W2557588886 @default.
- W2891282659 cites W2600130478 @default.
- W2891282659 cites W2600902797 @default.
- W2891282659 cites W2604947514 @default.
- W2891282659 cites W2605282287 @default.
- W2891282659 cites W2756821926 @default.
- W2891282659 cites W2763174077 @default.
- W2891282659 cites W4231362214 @default.
- W2891282659 cites W4241300192 @default.
- W2891282659 doi "https://doi.org/10.1038/s42003-018-0148-x" @default.
- W2891282659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6131551" @default.
- W2891282659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272018" @default.
- W2891282659 hasPublicationYear "2018" @default.
- W2891282659 type Work @default.
- W2891282659 sameAs 2891282659 @default.
- W2891282659 citedByCount "42" @default.
- W2891282659 countsByYear W28912826592018 @default.
- W2891282659 countsByYear W28912826592019 @default.
- W2891282659 countsByYear W28912826592020 @default.
- W2891282659 countsByYear W28912826592021 @default.
- W2891282659 countsByYear W28912826592022 @default.
- W2891282659 countsByYear W28912826592023 @default.
- W2891282659 crossrefType "journal-article" @default.
- W2891282659 hasAuthorship W2891282659A5008748795 @default.
- W2891282659 hasAuthorship W2891282659A5031776025 @default.
- W2891282659 hasAuthorship W2891282659A5035182510 @default.
- W2891282659 hasAuthorship W2891282659A5091068908 @default.
- W2891282659 hasBestOaLocation W28912826591 @default.
- W2891282659 hasConcept C12554922 @default.
- W2891282659 hasConcept C136238340 @default.
- W2891282659 hasConcept C142724271 @default.
- W2891282659 hasConcept C147080431 @default.
- W2891282659 hasConcept C169760540 @default.
- W2891282659 hasConcept C185592680 @default.
- W2891282659 hasConcept C192562407 @default.
- W2891282659 hasConcept C2779134260 @default.
- W2891282659 hasConcept C2780596555 @default.
- W2891282659 hasConcept C71924100 @default.
- W2891282659 hasConcept C79879829 @default.
- W2891282659 hasConcept C86803240 @default.
- W2891282659 hasConcept C95444343 @default.
- W2891282659 hasConceptScore W2891282659C12554922 @default.
- W2891282659 hasConceptScore W2891282659C136238340 @default.
- W2891282659 hasConceptScore W2891282659C142724271 @default.
- W2891282659 hasConceptScore W2891282659C147080431 @default.
- W2891282659 hasConceptScore W2891282659C169760540 @default.
- W2891282659 hasConceptScore W2891282659C185592680 @default.
- W2891282659 hasConceptScore W2891282659C192562407 @default.
- W2891282659 hasConceptScore W2891282659C2779134260 @default.
- W2891282659 hasConceptScore W2891282659C2780596555 @default.