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• W2891284664 abstract "ABSTRACT The Drosophila embryonic tracheal network is an excellent model to study tube size. The chitin-based apical luminal matrix and cell polarity are well known to regulate tube size in Drosophila trachea. Defects in luminal matrix and cell polarity lead to tube overexpansion. Here, we address the novel function of the rebuff (reb) gene, which encodes an evolutionarily conserved Smad-like protein. In reb mutants, tracheal tubes are moderately over-elongated. Despite the establishment of normal cell polarity, we observed significantly reduced apical luminal matrix in reb mutants. Among various luminal components, luminal Obstructor-A (ObstA) is drastically reduced. Interestingly, ObstA is localized in vesicle-like structures that are apically concentrated in reb mutants. To investigate the possibility that reb is involved in the endocytosis of ObstA, we analyzed the co-localization of ObstA and endocytic markers in reb mutants. We observed that ObstA is localized in late endosomes and recycling endosomes. This suggests that in reb mutant trachea, endocytosed ObstA is degraded or recycled back to the apical region. However, ObstA vesicles are retained in the apical region and are failed to be secreted to the lumen. Taken together, these results suggest one function of reb is regulating the endocytosis of luminal matrix components." @default.
• W2891284664 created "2018-09-27" @default.
• W2891284664 creator A5018857167 @default.
• W2891284664 creator A5063271814 @default.
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• W2891284664 date "2018-09-05" @default.
• W2891284664 modified "2023-09-24" @default.
• W2891284664 title "rebuff regulates apical luminal matrix to control tube size in Drosophila trachea" @default.
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• W2891284664 doi "https://doi.org/10.1242/bio.036848" @default.
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• W2891284664 hasPublicationYear "2018" @default.
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