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- W2891286788 abstract "To support tissue and organ development, cells transition between epithelial and mesenchymal states. Here we investigated how mesoderm cells change state in Drosophila embryos and whether fibroblast growth factor (FGF) signaling plays a role. During gastrulation, presumptive mesoderm cells invaginate, undergo an epithelial-to-mesenchymal state transition (EMT) and migrate upon the ectoderm. Our data show that EMT is a prolonged process in which adherens junctions progressively decrease in number throughout the mesoderm cells’ migration. FGF influences adherens junction number and promotes mesoderm cell division, which we propose decreases cell-cell attachments to support slow EMT while retaining collective cell movement. We also found that, at the completion of migration, cells form a monolayer and undergo a reverse mesenchymal-to-epithelial transition (MET). FGF activity leads to accumulation of beta-integrin Myospheroid basally and cell polarity factor Bazooka apically within mesoderm cells, thereby reestablishing apicobasal cell polarity in an epithelialized state in which cells express both E-Cadherin and N-Cadherin. In summary, FGF plays a dynamic role in supporting mesoderm cell development to ensure collective mesoderm cell movements as well as proper differentiation of mesoderm cell types." @default.
- W2891286788 created "2018-09-27" @default.
- W2891286788 creator A5005248189 @default.
- W2891286788 creator A5069125975 @default.
- W2891286788 date "2018-01-01" @default.
- W2891286788 modified "2023-10-01" @default.
- W2891286788 title "FGF controls epithelial-mesenchymal transitions during gastrulation by regulating cell division and apicobasal polarity" @default.
- W2891286788 cites W1618500214 @default.
- W2891286788 cites W1787157135 @default.
- W2891286788 cites W1863574466 @default.
- W2891286788 cites W1866991157 @default.
- W2891286788 cites W1938204331 @default.
- W2891286788 cites W1964081206 @default.
- W2891286788 cites W1968981755 @default.
- W2891286788 cites W1970147973 @default.
- W2891286788 cites W1970656914 @default.
- W2891286788 cites W1976015563 @default.
- W2891286788 cites W1976226144 @default.
- W2891286788 cites W1977746306 @default.
- W2891286788 cites W1979218529 @default.
- W2891286788 cites W1979723568 @default.
- W2891286788 cites W1984046181 @default.
- W2891286788 cites W1984562849 @default.
- W2891286788 cites W1986084227 @default.
- W2891286788 cites W1993019988 @default.
- W2891286788 cites W1998888750 @default.
- W2891286788 cites W1998904944 @default.
- W2891286788 cites W2004655327 @default.
- W2891286788 cites W2015114060 @default.
- W2891286788 cites W2015887548 @default.
- W2891286788 cites W2018947638 @default.
- W2891286788 cites W2019114545 @default.
- W2891286788 cites W2019118567 @default.
- W2891286788 cites W2019482668 @default.
- W2891286788 cites W2023650634 @default.
- W2891286788 cites W2026161399 @default.
- W2891286788 cites W2034064894 @default.
- W2891286788 cites W2040255583 @default.
- W2891286788 cites W2048641999 @default.
- W2891286788 cites W2049162644 @default.
- W2891286788 cites W2050032205 @default.
- W2891286788 cites W2050346490 @default.
- W2891286788 cites W2050771413 @default.
- W2891286788 cites W2054195724 @default.
- W2891286788 cites W2055083701 @default.
- W2891286788 cites W2056020456 @default.
- W2891286788 cites W2057974199 @default.
- W2891286788 cites W2058527255 @default.
- W2891286788 cites W2058624823 @default.
- W2891286788 cites W2068877404 @default.
- W2891286788 cites W2069925342 @default.
- W2891286788 cites W2080064943 @default.
- W2891286788 cites W2082141328 @default.
- W2891286788 cites W2083918887 @default.
- W2891286788 cites W2087367170 @default.
- W2891286788 cites W2087554888 @default.
- W2891286788 cites W2088667155 @default.
- W2891286788 cites W2089839677 @default.
- W2891286788 cites W2091154399 @default.
- W2891286788 cites W2091641911 @default.
- W2891286788 cites W2093080262 @default.
- W2891286788 cites W2100338747 @default.
- W2891286788 cites W2100549778 @default.
- W2891286788 cites W2100860947 @default.
- W2891286788 cites W2102823679 @default.
- W2891286788 cites W2104036987 @default.
- W2891286788 cites W2110197429 @default.
- W2891286788 cites W2115485398 @default.
- W2891286788 cites W2122177126 @default.
- W2891286788 cites W2122179786 @default.
- W2891286788 cites W2126383647 @default.
- W2891286788 cites W2130023674 @default.
- W2891286788 cites W2133274338 @default.
- W2891286788 cites W2136032801 @default.
- W2891286788 cites W2140551998 @default.
- W2891286788 cites W2145675193 @default.
- W2891286788 cites W2147677686 @default.
- W2891286788 cites W2149687327 @default.
- W2891286788 cites W2153160639 @default.
- W2891286788 cites W2154430272 @default.
- W2891286788 cites W2157700111 @default.
- W2891286788 cites W2164358503 @default.
- W2891286788 cites W2167018922 @default.
- W2891286788 cites W2167742206 @default.
- W2891286788 cites W2233885509 @default.
- W2891286788 cites W2289630595 @default.
- W2891286788 cites W2323234088 @default.
- W2891286788 cites W2558772117 @default.
- W2891286788 cites W2571262948 @default.
- W2891286788 cites W2576799546 @default.
- W2891286788 cites W2618156145 @default.
- W2891286788 cites W307698176 @default.
- W2891286788 cites W4063809 @default.
- W2891286788 cites W4249890897 @default.
- W2891286788 cites W4250170407 @default.
- W2891286788 doi "https://doi.org/10.1242/dev.161927" @default.
- W2891286788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198468" @default.
- W2891286788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190277" @default.
- W2891286788 hasPublicationYear "2018" @default.
- W2891286788 type Work @default.