FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891287420> ?p ?o ?g. }

• W2891287420 endingPage "436" @default.
• W2891287420 startingPage "429" @default.
• W2891287420 abstract "There have been many advances in the diagnosis and therapeutic management of systemic lupus erythematosus (SLE) over the past decades. Following more than eleven centuries of therapeutic uncertainty, the discovery of the therapeutic properties of glucocorticoids is without any doubt one of the most significant advance in the field of autoimmune diseases. The many progresses made by rapidly growing chemical industry of the 19th century chemistry have allowed the identification of valuable therapeutic compounds such as anti-malarials, cyclophosphamide, azathioprine, cyclosporine and later mycophenolate mofetil, which have all profoundly changed the face of the disease. A very visible consequence of this is the profound improvement in the prognosis of the disease, with 10-year survival rates of more than 90% in most dedicated centres. Following the development of biotherapies in rheumatoid arthritis, the late 20th century has slowly opened a new era for the treatment of SLE, that of targeted therapies. With the approval of belimumab in 2011 and 74 targeted therapies in clinical development, we may expect great changes in the therapeutic management of SLE. Those molecules target inflammatory cytokines or chemokines and their receptors, B cells or plasma cells, intracellular signalling pathways, B/T cells co-stimulation molecules, interferons, plasmacytoid dendritic cells, as well as various other targets of interest. Current challenges are now slowly shifting from whether some new drugs will be available to how to select the most adequate drug (or drug combination) at the patient-level." @default.
• W2891287420 created "2018-09-27" @default.
• W2891287420 creator A5038884673 @default.
• W2891287420 creator A5042352289 @default.
• W2891287420 creator A5070589258 @default.
• W2891287420 creator A5080881858 @default.
• W2891287420 creator A5082120478 @default.
• W2891287420 date "2019-07-01" @default.
• W2891287420 modified "2023-10-14" @default.
• W2891287420 title "Advances in the treatment of systemic lupus erythematosus: From back to the future, to the future and beyond" @default.
• W2891287420 cites W1688265474 @default.
• W2891287420 cites W1759546812 @default.
• W2891287420 cites W1920115643 @default.
• W2891287420 cites W1920228500 @default.
• W2891287420 cites W1921064336 @default.
• W2891287420 cites W1970821494 @default.
• W2891287420 cites W1971057505 @default.
• W2891287420 cites W1971058219 @default.
• W2891287420 cites W1976244538 @default.
• W2891287420 cites W1978058499 @default.
• W2891287420 cites W1995365224 @default.
• W2891287420 cites W2000054082 @default.
• W2891287420 cites W2014321321 @default.
• W2891287420 cites W2015040567 @default.
• W2891287420 cites W2024442997 @default.
• W2891287420 cites W2026348651 @default.
• W2891287420 cites W2042691643 @default.
• W2891287420 cites W2049632532 @default.
• W2891287420 cites W2068121948 @default.
• W2891287420 cites W2081704353 @default.
• W2891287420 cites W2082428789 @default.
• W2891287420 cites W2083311992 @default.
• W2891287420 cites W2094074845 @default.
• W2891287420 cites W2096194879 @default.
• W2891287420 cites W2101322831 @default.
• W2891287420 cites W2111077593 @default.
• W2891287420 cites W2118080440 @default.
• W2891287420 cites W2119837784 @default.
• W2891287420 cites W2120636311 @default.
• W2891287420 cites W2125094181 @default.
• W2891287420 cites W2125546865 @default.
• W2891287420 cites W2131457901 @default.
• W2891287420 cites W2131469748 @default.
• W2891287420 cites W2136149088 @default.
• W2891287420 cites W2140034709 @default.
• W2891287420 cites W2148880753 @default.
• W2891287420 cites W2157239580 @default.
• W2891287420 cites W2168030824 @default.
• W2891287420 cites W2256462634 @default.
• W2891287420 cites W2320229582 @default.
• W2891287420 cites W2321809676 @default.
• W2891287420 cites W2325870812 @default.
• W2891287420 cites W2336763384 @default.
• W2891287420 cites W2376792986 @default.
• W2891287420 cites W2414006052 @default.
• W2891287420 cites W2477823035 @default.
• W2891287420 cites W2549420521 @default.
• W2891287420 cites W2550186240 @default.
• W2891287420 cites W2553948261 @default.
• W2891287420 cites W2556359407 @default.
• W2891287420 cites W2581044336 @default.
• W2891287420 cites W2591987720 @default.
• W2891287420 cites W2600952481 @default.
• W2891287420 cites W2606492431 @default.
• W2891287420 cites W2761042308 @default.
• W2891287420 cites W2765532092 @default.
• W2891287420 cites W2789202960 @default.
• W2891287420 cites W2806152658 @default.
• W2891287420 cites W2883700530 @default.
• W2891287420 cites W631375911 @default.
• W2891287420 doi "https://doi.org/10.1016/j.jbspin.2018.09.004" @default.
• W2891287420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243784" @default.
• W2891287420 hasPublicationYear "2019" @default.
• W2891287420 type Work @default.
• W2891287420 sameAs 2891287420 @default.
• W2891287420 citedByCount "24" @default.
• W2891287420 countsByYear W28912874202019 @default.
• W2891287420 countsByYear W28912874202020 @default.
• W2891287420 countsByYear W28912874202021 @default.
• W2891287420 countsByYear W28912874202022 @default.
• W2891287420 countsByYear W28912874202023 @default.
• W2891287420 crossrefType "journal-article" @default.
• W2891287420 hasAuthorship W2891287420A5038884673 @default.
• W2891287420 hasAuthorship W2891287420A5042352289 @default.
• W2891287420 hasAuthorship W2891287420A5070589258 @default.
• W2891287420 hasAuthorship W2891287420A5080881858 @default.
• W2891287420 hasAuthorship W2891287420A5082120478 @default.
• W2891287420 hasBestOaLocation W28912874201 @default.
• W2891287420 hasConcept C126322002 @default.
• W2891287420 hasConcept C159654299 @default.
• W2891287420 hasConcept C170286685 @default.
• W2891287420 hasConcept C177713679 @default.
• W2891287420 hasConcept C203014093 @default.
• W2891287420 hasConcept C2776694085 @default.
• W2891287420 hasConcept C2776755627 @default.
• W2891287420 hasConcept C2776760755 @default.
• W2891287420 hasConcept C2776912625 @default.
• W2891287420 hasConcept C2777178219 @default.

• next