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- W2891288898 abstract "Classically, eosinophilic esophagitis is an antigen-mediated chronic disease distinct from gastroesophageal reflux disease. Eosinophilic esophagitis is an emerging clinical problem that is growing in recognition. It is characterized clinically by feeding dysfunction, dysphagia, and reflux-like symptoms. Histologically, eosinophilic esophagitis is identifiable by a dense epithelial eosinophilic infiltrate. Experimental modeling and clinical studies over the last decade have greatly improved mechanistic insights and led to improvements in clinical understanding and the assessment of therapeutic options for patients and their clinicians who manage this disease. Here, we review the clinicopathologic diagnostic criteria and our understanding of eosinophilic esophagitis as an allergic disease with genetic and immunological components. We present studies defining the importance of the epithelial barrier and the concept of barrier dysfunction as an initiating or perpetuating factor for this disease. We discuss the relationship between the symptoms of dysphagia and feeding dysfunction, our current knowledge of the underlying pathophysiologic mechanisms, and advances in clinical assessment of esophageal distensibility and narrowing in eosinophilic esophagitis patients. Finally, therapeutic implications relating to the advances that have led to our current understanding of the pathophysiology of eosinophilic esophagitis are explored." @default.
- W2891288898 created "2018-09-27" @default.
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- W2891288898 creator A5042758002 @default.
- W2891288898 creator A5055514646 @default.
- W2891288898 creator A5062401038 @default.
- W2891288898 date "2018-11-01" @default.
- W2891288898 modified "2023-10-16" @default.
- W2891288898 title "Eosinophilic esophagitis: pathophysiology and its clinical implications" @default.
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- W2891288898 doi "https://doi.org/10.1152/ajpgi.00174.2018" @default.
- W2891288898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6293259" @default.
- W2891288898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30212252" @default.
- W2891288898 hasPublicationYear "2018" @default.
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