Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891290392> ?p ?o ?g. }
- W2891290392 abstract "Retrogradely-transported neurotrophin signaling plays an important role in regulating neural circuit specificity. Here we investigated whether targeted delivery of neurotrophin-3 (NT-3) to lumbar motoneurons (MNs) caudal to a thoracic (T10) contusive spinal cord injury (SCI) could modulate dendritic patterning and synapse formation of the lumbar MNs. In vitro, Adeno-associated virus serotype two overexpressing NT-3 (AAV-NT-3) induced NT-3 expression and neurite outgrowth in cultured spinal cord neurons. In vivo, targeted delivery of AAV-NT-3 into transiently demyelinated adult mouse sciatic nerves led to the retrograde transportation of NT-3 to the lumbar MNs, significantly attenuating SCI-induced lumbar MN dendritic atrophy. NT-3 enhanced sprouting and synaptic formation of descending serotonergic, dopaminergic, and propriospinal axons on lumbar MNs, parallel to improved behavioral recovery. Thus, retrogradely transported NT-3 stimulated remodeling of lumbar neural circuitry and synaptic connectivity remote to a thoracic SCI, supporting a role for retrograde transport of NT-3 as a potential therapeutic strategy for SCI." @default.
- W2891290392 created "2018-09-27" @default.
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- W2891290392 date "2018-09-12" @default.
- W2891290392 modified "2023-10-16" @default.
- W2891290392 title "Remodeling of lumbar motor circuitry remote to a thoracic spinal cord injury promotes locomotor recovery" @default.
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- W2891290392 doi "https://doi.org/10.7554/elife.39016" @default.
- W2891290392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6170189" @default.
- W2891290392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30207538" @default.