FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891290469> ?p ?o ?g. }

• W2891290469 endingPage "475" @default.
• W2891290469 startingPage "475" @default.
• W2891290469 abstract "Biophysical properties are widely used to detect pathophysiological processes of vascular diseases or clinical states. For early detection of cardiovascular diseases, it is necessary to simultaneously measure multiple biophysical properties in a microfluidic environment. However, a microfluidic-based technique for measuring multiple biophysical properties has not been demonstrated. In this study, a simple measurement method was suggested to quantify three biophysical properties of blood, including red blood cell (RBC) deformability, RBC aggregation, and hematocrit. To demonstrate the suggested method, a microfluidic device was constructed, being composed of a big-sized channel (BC), a parallel micropillar (MP), a main channel, a branch channel, inlet, and outlets. By operating a single syringe pump, blood was supplied into the inlet of the microfluidic device, at a periodic on-off profile (i.e., period = 240 s). The RBC deformability index (DI) was obtained by analyzing the averaged blood velocity in the branch channel. Additionally, the RBC aggregation index (AIN) and the hematocrit index (HiBC) were measured by analyzing the image intensity of blood flows in the MP and the BC, respectively. The corresponding contributions of three influencing factors, including the turn-on time (Ton), the amplitude of blood flow rate (Q0), and the hematocrit (Hct) on the biophysical indices (DI, AIN, and HiBC) were evaluated quantitatively. As the three biophysical indices varied significantly with respect to the three factors, the following conditions (i.e., Ton = 210 s, Q0 = 1 mL/h, and Hct = 50%) were maintained for consistent measurement of biophysical properties. The proposed method was employed to detect variations of biophysical properties depending on the concentrations of autologous plasma, homogeneous hardened RBCs, and heterogeneous hardened RBCs. Based on the observations, the proposed method exhibited significant differences in biophysical properties depending on base solutions, homogeneous hardened RBCs (i.e., all RBCs fixed with the same concentration of glutaraldehyde solution), and heterogeneous hardened RBCs (i.e., partially mixed with normal RBCs and homogeneous hardened RBCs). Additionally, the suggested indices (i.e., DI, AIN, and HiBC) were effectively employed to quantify three biophysical properties, including RBC deformability, RBC aggregation, and hematocrit." @default.
• W2891290469 created "2018-09-27" @default.
• W2891290469 creator A5059577696 @default.
• W2891290469 date "2018-09-20" @default.
• W2891290469 modified "2023-09-29" @default.
• W2891290469 title "A Disposable Blood-on-a-Chip for Simultaneous Measurement of Multiple Biophysical Properties" @default.
• W2891290469 cites W1482111343 @default.
• W2891290469 cites W1759832903 @default.
• W2891290469 cites W1920794742 @default.
• W2891290469 cites W1952658372 @default.
• W2891290469 cites W1967235506 @default.
• W2891290469 cites W1987058050 @default.
• W2891290469 cites W1994497032 @default.
• W2891290469 cites W2013973305 @default.
• W2891290469 cites W2031683385 @default.
• W2891290469 cites W2045734313 @default.
• W2891290469 cites W2055099137 @default.
• W2891290469 cites W2071883091 @default.
• W2891290469 cites W2072668992 @default.
• W2891290469 cites W2079832375 @default.
• W2891290469 cites W2098708326 @default.
• W2891290469 cites W2118866778 @default.
• W2891290469 cites W2119214230 @default.
• W2891290469 cites W2121221073 @default.
• W2891290469 cites W2123211570 @default.
• W2891290469 cites W2131484460 @default.
• W2891290469 cites W2138576320 @default.
• W2891290469 cites W2148868397 @default.
• W2891290469 cites W2149057006 @default.
• W2891290469 cites W2170631492 @default.
• W2891290469 cites W2170972467 @default.
• W2891290469 cites W2186692249 @default.
• W2891290469 cites W2253728142 @default.
• W2891290469 cites W2514418219 @default.
• W2891290469 cites W2547317388 @default.
• W2891290469 cites W2551335704 @default.
• W2891290469 cites W2563318820 @default.
• W2891290469 cites W2568202803 @default.
• W2891290469 cites W2597171131 @default.
• W2891290469 cites W2627068340 @default.
• W2891290469 cites W2752717967 @default.
• W2891290469 cites W2788762981 @default.
• W2891290469 cites W2797765056 @default.
• W2891290469 cites W2809280844 @default.
• W2891290469 cites W2886771412 @default.
• W2891290469 doi "https://doi.org/10.3390/mi9100475" @default.
• W2891290469 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6215101" @default.
• W2891290469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30424408" @default.
• W2891290469 hasPublicationYear "2018" @default.
• W2891290469 type Work @default.
• W2891290469 sameAs 2891290469 @default.
• W2891290469 citedByCount "8" @default.
• W2891290469 countsByYear W28912904692019 @default.
• W2891290469 countsByYear W28912904692020 @default.
• W2891290469 countsByYear W28912904692022 @default.
• W2891290469 countsByYear W28912904692023 @default.
• W2891290469 crossrefType "journal-article" @default.
• W2891290469 hasAuthorship W2891290469A5059577696 @default.
• W2891290469 hasBestOaLocation W28912904691 @default.
• W2891290469 hasConcept C126322002 @default.
• W2891290469 hasConcept C136229726 @default.
• W2891290469 hasConcept C158846371 @default.
• W2891290469 hasConcept C164705383 @default.
• W2891290469 hasConcept C171250308 @default.
• W2891290469 hasConcept C185592680 @default.
• W2891290469 hasConcept C192562407 @default.
• W2891290469 hasConcept C2776557347 @default.
• W2891290469 hasConcept C2780959883 @default.
• W2891290469 hasConcept C55493867 @default.
• W2891290469 hasConcept C71924100 @default.
• W2891290469 hasConcept C8673954 @default.
• W2891290469 hasConceptScore W2891290469C126322002 @default.
• W2891290469 hasConceptScore W2891290469C136229726 @default.
• W2891290469 hasConceptScore W2891290469C158846371 @default.
• W2891290469 hasConceptScore W2891290469C164705383 @default.
• W2891290469 hasConceptScore W2891290469C171250308 @default.
• W2891290469 hasConceptScore W2891290469C185592680 @default.
• W2891290469 hasConceptScore W2891290469C192562407 @default.
• W2891290469 hasConceptScore W2891290469C2776557347 @default.
• W2891290469 hasConceptScore W2891290469C2780959883 @default.
• W2891290469 hasConceptScore W2891290469C55493867 @default.
• W2891290469 hasConceptScore W2891290469C71924100 @default.
• W2891290469 hasConceptScore W2891290469C8673954 @default.
• W2891290469 hasFunder F4320322120 @default.
• W2891290469 hasIssue "10" @default.
• W2891290469 hasLocation W28912904691 @default.
• W2891290469 hasLocation W28912904692 @default.
• W2891290469 hasLocation W28912904693 @default.
• W2891290469 hasLocation W28912904694 @default.
• W2891290469 hasOpenAccess W2891290469 @default.
• W2891290469 hasPrimaryLocation W28912904691 @default.
• W2891290469 hasRelatedWork W2040284588 @default.
• W2891290469 hasRelatedWork W2094475932 @default.
• W2891290469 hasRelatedWork W2159125836 @default.
• W2891290469 hasRelatedWork W2291702743 @default.
• W2891290469 hasRelatedWork W2419642910 @default.
• W2891290469 hasRelatedWork W2460061332 @default.
• W2891290469 hasRelatedWork W2548619100 @default.

• next