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• W2891291514 abstract "Until recently, therapeutic development in psychiatry was targeted solely toward symptom reduction. While this is a worthwhile goal, it has yielded little progress in improved therapeutics in the last several decades in the field of mood disorders. Recent advancements in our understanding of pathophysiology suggests that an impairment of neuroplasticity may be a critical part of the development of neuropsychiatric disorders. Interventions that enhance or modulate neuroplasticity often reduce depressive symptoms when applied as stand-alone treatments. Unfortunately, when treatments are discontinued, the disease state often returns as patients relapse. However, treatments that enhance or modulate plasticity not only reduce symptom burden, but also may provide an opportune window wherein cognitive or behavioral interventions could be introduced to harness a state of enhanced neuroplasticity and lead to improved longer-term clinical outcomes. Here, we review the potential of synergistically combining plasticity-enhancing and behavioral therapies to develop novel translational treatment approaches for depression. After reviewing relevant neuroplasticity deficits in depression, we survey biological treatments that appear to reverse such deficits in humans, including N-methyl-D-aspartate receptor modulators (ketamine, D-cycloserine), electroconvulsive therapy, and transcranial brain stimulation. We then review evidence that either directly or indirectly supports the hypothesis that a robust enhancement of neuroplasticity through these methods might promote the uptake of cognitive and behavioral interventions to enhance longer-term treatment outcomes through a synergistic effect. We identify key missing pieces of evidence and discuss future directions to enhance this emerging line of research." @default.
• W2891291514 created "2018-09-27" @default.
• W2891291514 creator A5012100855 @default.
• W2891291514 creator A5016572108 @default.
• W2891291514 creator A5023336112 @default.
• W2891291514 creator A5051669302 @default.
• W2891291514 creator A5078058389 @default.
• W2891291514 date "2019-03-01" @default.
• W2891291514 modified "2023-10-17" @default.
• W2891291514 title "Leveraging Neuroplasticity to Enhance Adaptive Learning: The Potential for Synergistic Somatic-Behavioral Treatment Combinations to Improve Clinical Outcomes in Depression" @default.
• W2891291514 cites W1784827336 @default.
• W2891291514 cites W1865092458 @default.
• W2891291514 cites W1961364466 @default.
• W2891291514 cites W1969476117 @default.
• W2891291514 cites W1969644317 @default.
• W2891291514 cites W1969919708 @default.
• W2891291514 cites W1971146523 @default.
• W2891291514 cites W1973474257 @default.
• W2891291514 cites W1975487521 @default.
• W2891291514 cites W1976073163 @default.
• W2891291514 cites W1978566598 @default.
• W2891291514 cites W1978793135 @default.
• W2891291514 cites W1979822895 @default.
• W2891291514 cites W1980053755 @default.
• W2891291514 cites W1980475719 @default.
• W2891291514 cites W1981102054 @default.
• W2891291514 cites W1982204460 @default.
• W2891291514 cites W1983948453 @default.
• W2891291514 cites W1985237413 @default.
• W2891291514 cites W1986936647 @default.
• W2891291514 cites W1987300108 @default.
• W2891291514 cites W1988975078 @default.
• W2891291514 cites W1989756802 @default.
• W2891291514 cites W1990477239 @default.
• W2891291514 cites W1990846151 @default.
• W2891291514 cites W1991517914 @default.
• W2891291514 cites W1997583789 @default.
• W2891291514 cites W2000104590 @default.
• W2891291514 cites W2003982930 @default.
• W2891291514 cites W2008281590 @default.
• W2891291514 cites W2012949854 @default.
• W2891291514 cites W2018390248 @default.
• W2891291514 cites W2020643162 @default.
• W2891291514 cites W2022555874 @default.
• W2891291514 cites W2023081218 @default.
• W2891291514 cites W2023170665 @default.
• W2891291514 cites W2024284755 @default.
• W2891291514 cites W2027093816 @default.
• W2891291514 cites W2028474863 @default.
• W2891291514 cites W2029888858 @default.
• W2891291514 cites W2030957288 @default.
• W2891291514 cites W2032916808 @default.
• W2891291514 cites W2036261911 @default.
• W2891291514 cites W2040333128 @default.
• W2891291514 cites W2047894110 @default.
• W2891291514 cites W2049990060 @default.
• W2891291514 cites W2052075745 @default.
• W2891291514 cites W2058637146 @default.
• W2891291514 cites W2060936341 @default.
• W2891291514 cites W2062103870 @default.
• W2891291514 cites W2067456882 @default.
• W2891291514 cites W2067534006 @default.
• W2891291514 cites W2071696563 @default.
• W2891291514 cites W2072079890 @default.
• W2891291514 cites W2072336593 @default.
• W2891291514 cites W2073164684 @default.
• W2891291514 cites W2076536745 @default.
• W2891291514 cites W2078936103 @default.
• W2891291514 cites W2079581133 @default.
• W2891291514 cites W2080080993 @default.
• W2891291514 cites W2080645517 @default.
• W2891291514 cites W2083601314 @default.
• W2891291514 cites W2084043765 @default.
• W2891291514 cites W2084354128 @default.
• W2891291514 cites W2085019344 @default.
• W2891291514 cites W2085066803 @default.
• W2891291514 cites W2088326070 @default.
• W2891291514 cites W2089351762 @default.
• W2891291514 cites W2091363925 @default.
• W2891291514 cites W2092094210 @default.
• W2891291514 cites W2094299755 @default.
• W2891291514 cites W2096856265 @default.
• W2891291514 cites W2098267330 @default.
• W2891291514 cites W2108057532 @default.
• W2891291514 cites W2109982075 @default.
• W2891291514 cites W2110004174 @default.
• W2891291514 cites W2111728433 @default.
• W2891291514 cites W2111963501 @default.
• W2891291514 cites W2113232677 @default.
• W2891291514 cites W2114525052 @default.
• W2891291514 cites W2115504852 @default.
• W2891291514 cites W2115540935 @default.
• W2891291514 cites W2118521160 @default.
• W2891291514 cites W2118815581 @default.
• W2891291514 cites W2120784916 @default.
• W2891291514 cites W2123488676 @default.
• W2891291514 cites W2129310294 @default.
• W2891291514 cites W2131398580 @default.

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