FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891291713> ?p ?o ?g. }

• W2891291713 endingPage "46" @default.
• W2891291713 startingPage "34" @default.
• W2891291713 abstract "The current study was designed to explore the underlying therapeutic effect of berberine (BBR), an alkaloid compound against LPS (1 μg/ml)/TNFα (10 ng/ml) mediated apoptosis signal-regulating kinase 1 (ASK1) signaling in RAW 264.7 macrophages and adjuvant-induced arthritic synovial macrophages (AA-SM) with relation to miR-23a levels. LPS and TNFα stimulation abrogated the expression of miR-23a resulting in TLR4/TRAF2 mediated ASK1 activation and downstream phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK). BBR (25–75 μM) treatment ameliorated the gene expression levels of TLR4, TRAF2, TNFα, IL-6, and IL-23 through the upregulation of miR-23a. Subsequently, BBR suppressed the levels of TLR4/TRAF2 mediated phosphorylation of ASK1/p38 and attenuated the expression of various pro-inflammatory cytokines (TNFα, IL-6 & IL-23) in RAW 264.7 macrophages and AA-SM cells. BBR was able to counteract these factors through activation of miR-23a levels in LPS/TNFα stimulated RAW 264.7 macrophages and AA-SM cells. NQDI1 (30 μM) treatment inhibited ASK1 activation resulting in basal levels of miR-23a, owing to the conclusion that ASK1 activation downregulates miR-23a levels inside the cells. Overall, our current findings predict that BBR is a potential candidate for therapeutic targeting of TLR4/TRAF2 mediated ASK1 activation in inflammatory and in RA pathogenesis possibly through post-transcriptional gene silencing via upregulation of miR-23a." @default.
• W2891291713 created "2018-09-27" @default.
• W2891291713 creator A5011206344 @default.
• W2891291713 creator A5043136416 @default.
• W2891291713 creator A5077227815 @default.
• W2891291713 date "2018-11-01" @default.
• W2891291713 modified "2023-09-25" @default.
• W2891291713 title "Berberine modulates ASK1 signaling mediated through TLR4/TRAF2 via upregulation of miR-23a" @default.
• W2891291713 cites W1538469697 @default.
• W2891291713 cites W1563489808 @default.
• W2891291713 cites W1586581625 @default.
• W2891291713 cites W162922609 @default.
• W2891291713 cites W1751722025 @default.
• W2891291713 cites W1798331267 @default.
• W2891291713 cites W1972296048 @default.
• W2891291713 cites W1998263932 @default.
• W2891291713 cites W2002086531 @default.
• W2891291713 cites W2004929000 @default.
• W2891291713 cites W2023121881 @default.
• W2891291713 cites W2031503714 @default.
• W2891291713 cites W2049885705 @default.
• W2891291713 cites W2075494813 @default.
• W2891291713 cites W2085823870 @default.
• W2891291713 cites W2098001153 @default.
• W2891291713 cites W2099273585 @default.
• W2891291713 cites W2125674757 @default.
• W2891291713 cites W2125792512 @default.
• W2891291713 cites W2140102579 @default.
• W2891291713 cites W2161425478 @default.
• W2891291713 cites W2291694997 @default.
• W2891291713 cites W2345955430 @default.
• W2891291713 cites W2355876222 @default.
• W2891291713 cites W2396003270 @default.
• W2891291713 cites W2396894181 @default.
• W2891291713 cites W2402696913 @default.
• W2891291713 cites W2404084156 @default.
• W2891291713 cites W2412832086 @default.
• W2891291713 cites W2438365887 @default.
• W2891291713 cites W2465847244 @default.
• W2891291713 cites W2492594183 @default.
• W2891291713 cites W2514090592 @default.
• W2891291713 cites W2560080983 @default.
• W2891291713 cites W2566283148 @default.
• W2891291713 cites W2572422543 @default.
• W2891291713 cites W2591619117 @default.
• W2891291713 cites W2602753743 @default.
• W2891291713 cites W2611036723 @default.
• W2891291713 cites W2626811882 @default.
• W2891291713 cites W2727588918 @default.
• W2891291713 cites W2735953961 @default.
• W2891291713 cites W2756093409 @default.
• W2891291713 cites W2766287142 @default.
• W2891291713 cites W2767402071 @default.
• W2891291713 cites W2792056556 @default.
• W2891291713 cites W4253796858 @default.
• W2891291713 cites W755401697 @default.
• W2891291713 doi "https://doi.org/10.1016/j.taap.2018.09.017" @default.
• W2891291713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30240693" @default.
• W2891291713 hasPublicationYear "2018" @default.
• W2891291713 type Work @default.
• W2891291713 sameAs 2891291713 @default.
• W2891291713 citedByCount "18" @default.
• W2891291713 countsByYear W28912917132019 @default.
• W2891291713 countsByYear W28912917132020 @default.
• W2891291713 countsByYear W28912917132021 @default.
• W2891291713 countsByYear W28912917132022 @default.
• W2891291713 countsByYear W28912917132023 @default.
• W2891291713 crossrefType "journal-article" @default.
• W2891291713 hasAuthorship W2891291713A5011206344 @default.
• W2891291713 hasAuthorship W2891291713A5043136416 @default.
• W2891291713 hasAuthorship W2891291713A5077227815 @default.
• W2891291713 hasConcept C104317684 @default.
• W2891291713 hasConcept C119056186 @default.
• W2891291713 hasConcept C123233396 @default.
• W2891291713 hasConcept C124160383 @default.
• W2891291713 hasConcept C127561419 @default.
• W2891291713 hasConcept C153911025 @default.
• W2891291713 hasConcept C17991360 @default.
• W2891291713 hasConcept C184235292 @default.
• W2891291713 hasConcept C185592680 @default.
• W2891291713 hasConcept C203014093 @default.
• W2891291713 hasConcept C2776070231 @default.
• W2891291713 hasConcept C502942594 @default.
• W2891291713 hasConcept C51551487 @default.
• W2891291713 hasConcept C55493867 @default.
• W2891291713 hasConcept C57074206 @default.
• W2891291713 hasConcept C62478195 @default.
• W2891291713 hasConcept C86803240 @default.
• W2891291713 hasConcept C90934575 @default.
• W2891291713 hasConcept C93880895 @default.
• W2891291713 hasConcept C95444343 @default.
• W2891291713 hasConcept C97029542 @default.
• W2891291713 hasConceptScore W2891291713C104317684 @default.
• W2891291713 hasConceptScore W2891291713C119056186 @default.
• W2891291713 hasConceptScore W2891291713C123233396 @default.
• W2891291713 hasConceptScore W2891291713C124160383 @default.
• W2891291713 hasConceptScore W2891291713C127561419 @default.
• W2891291713 hasConceptScore W2891291713C153911025 @default.

• next