Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891292903> ?p ?o ?g. }
- W2891292903 abstract "To elucidate the abnormality of cardiac vagal control in streptozotocin-induced type 1 diabetic rats, we measured left ventricular myocardial interstitial acetylcholine (ACh) release in response to α2-adrenergic stimulation as an index of in vivo cardiac vagal nerve activity. A cardiac microdialysis technique was applied to the rat left ventricle, and the effect of α2-adrenergic stimulation by intravenous medetomidine (100 μg/kg) on myocardial interstitial ACh levels was examined in anesthetized diabetic rats (4-6 weeks after intraperitoneal streptozotocin) and age-matched control rats (protocol 1). The effect of electrical vagal nerve stimulation on ACh levels was also examined in separate rats (protocol 2). In protocol 1, medetomidine increased the ACh levels in control (from 1.76 ± 0.65 to 3.13 ± 1.41 nM, P < 0.05, n = 7) but not in diabetic rats (from 2.01 ± 0.47 to 1.62 ± 0.34 nM, not significant, n = 7). In protocol 2, electrical vagal nerve stimulation at 20 Hz significantly increased the ACh levels in both control (from 1.49 ± 0.26 to 6.39 ± 1.81 nM, P < 0.001, n = 6) and diabetic rats (from 1.77 ± 0.54 to 6.98 ± 1.38 nM, P < 0.001, n = 6). In conclusion, medetomidine-induced central vagal activation was impaired in diabetic rats, whereas peripheral cardiac vagal control of ACh release was preserved. The impairment of central vagal activation may lead to relative sympathetic predominance and promote cardiovascular complications in diabetes." @default.
- W2891292903 created "2018-09-27" @default.
- W2891292903 creator A5019793016 @default.
- W2891292903 creator A5023309521 @default.
- W2891292903 creator A5041063008 @default.
- W2891292903 creator A5048753005 @default.
- W2891292903 creator A5052340761 @default.
- W2891292903 creator A5053892479 @default.
- W2891292903 creator A5057533040 @default.
- W2891292903 creator A5079194862 @default.
- W2891292903 date "2019-01-01" @default.
- W2891292903 modified "2023-09-25" @default.
- W2891292903 title "Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats" @default.
- W2891292903 cites W1502029423 @default.
- W2891292903 cites W1509565492 @default.
- W2891292903 cites W1511336021 @default.
- W2891292903 cites W1547292532 @default.
- W2891292903 cites W1968659387 @default.
- W2891292903 cites W1979688567 @default.
- W2891292903 cites W1991709973 @default.
- W2891292903 cites W1996411864 @default.
- W2891292903 cites W2000930351 @default.
- W2891292903 cites W2011124666 @default.
- W2891292903 cites W2013335712 @default.
- W2891292903 cites W2021206939 @default.
- W2891292903 cites W2022255764 @default.
- W2891292903 cites W2023652395 @default.
- W2891292903 cites W2030206271 @default.
- W2891292903 cites W2032435910 @default.
- W2891292903 cites W2041692227 @default.
- W2891292903 cites W2057142421 @default.
- W2891292903 cites W2061259096 @default.
- W2891292903 cites W2066304445 @default.
- W2891292903 cites W2066932119 @default.
- W2891292903 cites W2073266114 @default.
- W2891292903 cites W2107509507 @default.
- W2891292903 cites W2126945908 @default.
- W2891292903 cites W2135593770 @default.
- W2891292903 cites W2137786107 @default.
- W2891292903 cites W2139540538 @default.
- W2891292903 cites W2140359408 @default.
- W2891292903 cites W2185872949 @default.
- W2891292903 cites W2215590889 @default.
- W2891292903 cites W2405928563 @default.
- W2891292903 cites W2509916413 @default.
- W2891292903 cites W2564210989 @default.
- W2891292903 cites W2588788379 @default.
- W2891292903 cites W2596115041 @default.
- W2891292903 cites W2805773088 @default.
- W2891292903 cites W3127611755 @default.
- W2891292903 doi "https://doi.org/10.1016/j.autneu.2018.09.001" @default.
- W2891292903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30220605" @default.
- W2891292903 hasPublicationYear "2019" @default.
- W2891292903 type Work @default.
- W2891292903 sameAs 2891292903 @default.
- W2891292903 citedByCount "3" @default.
- W2891292903 countsByYear W28912929032019 @default.
- W2891292903 countsByYear W28912929032020 @default.
- W2891292903 crossrefType "journal-article" @default.
- W2891292903 hasAuthorship W2891292903A5019793016 @default.
- W2891292903 hasAuthorship W2891292903A5023309521 @default.
- W2891292903 hasAuthorship W2891292903A5041063008 @default.
- W2891292903 hasAuthorship W2891292903A5048753005 @default.
- W2891292903 hasAuthorship W2891292903A5052340761 @default.
- W2891292903 hasAuthorship W2891292903A5053892479 @default.
- W2891292903 hasAuthorship W2891292903A5057533040 @default.
- W2891292903 hasAuthorship W2891292903A5079194862 @default.
- W2891292903 hasConcept C126322002 @default.
- W2891292903 hasConcept C134018914 @default.
- W2891292903 hasConcept C158453852 @default.
- W2891292903 hasConcept C170493617 @default.
- W2891292903 hasConcept C22885893 @default.
- W2891292903 hasConcept C24998067 @default.
- W2891292903 hasConcept C2775910092 @default.
- W2891292903 hasConcept C2779280383 @default.
- W2891292903 hasConcept C2780087125 @default.
- W2891292903 hasConcept C2781404750 @default.
- W2891292903 hasConcept C42219234 @default.
- W2891292903 hasConcept C50156730 @default.
- W2891292903 hasConcept C529278444 @default.
- W2891292903 hasConcept C555293320 @default.
- W2891292903 hasConcept C71924100 @default.
- W2891292903 hasConceptScore W2891292903C126322002 @default.
- W2891292903 hasConceptScore W2891292903C134018914 @default.
- W2891292903 hasConceptScore W2891292903C158453852 @default.
- W2891292903 hasConceptScore W2891292903C170493617 @default.
- W2891292903 hasConceptScore W2891292903C22885893 @default.
- W2891292903 hasConceptScore W2891292903C24998067 @default.
- W2891292903 hasConceptScore W2891292903C2775910092 @default.
- W2891292903 hasConceptScore W2891292903C2779280383 @default.
- W2891292903 hasConceptScore W2891292903C2780087125 @default.
- W2891292903 hasConceptScore W2891292903C2781404750 @default.
- W2891292903 hasConceptScore W2891292903C42219234 @default.
- W2891292903 hasConceptScore W2891292903C50156730 @default.
- W2891292903 hasConceptScore W2891292903C529278444 @default.
- W2891292903 hasConceptScore W2891292903C555293320 @default.
- W2891292903 hasConceptScore W2891292903C71924100 @default.
- W2891292903 hasFunder F4320324030 @default.
- W2891292903 hasLocation W28912929031 @default.
- W2891292903 hasLocation W28912929032 @default.