Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891294324> ?p ?o ?g. }
- W2891294324 abstract "Abstract Cancer genome studies have significantly advanced our knowledge of somatic mutations. However, how these mutations accumulate in normal cells and whether they promote pre-cancerous lesions remains poorly understood. Here we perform a comprehensive analysis of normal tissues by utilizing RNA sequencing data from ∼6,700 samples across 29 normal tissues collected as part of the Genotype-Tissue Expression (GTEx) project. We identify somatic mutations using a newly developed pipeline, RNA-MuTect, for calling somatic mutations directly from RNA-seq samples and their matched-normal DNA. When applied to the GTEx dataset, we detect multiple variants across different tissues and find that mutation burden is associated with both the age of the individual and tissue proliferation rate. We also detect hotspot cancer mutations that share tissue specificity with their matched cancer type. This study is the first to analyze a large number of samples across multiple normal tissues, identifying clones with genomic aberrations observed in cancer." @default.
- W2891294324 created "2018-09-27" @default.
- W2891294324 creator A5001392592 @default.
- W2891294324 creator A5002298496 @default.
- W2891294324 creator A5002408678 @default.
- W2891294324 creator A5003120045 @default.
- W2891294324 creator A5006597429 @default.
- W2891294324 creator A5007200139 @default.
- W2891294324 creator A5024842995 @default.
- W2891294324 creator A5025870661 @default.
- W2891294324 creator A5030679733 @default.
- W2891294324 creator A5032002195 @default.
- W2891294324 creator A5044445109 @default.
- W2891294324 creator A5050581967 @default.
- W2891294324 creator A5057715705 @default.
- W2891294324 creator A5064111090 @default.
- W2891294324 creator A5064519985 @default.
- W2891294324 creator A5066164969 @default.
- W2891294324 creator A5069565984 @default.
- W2891294324 creator A5076120149 @default.
- W2891294324 creator A5079809176 @default.
- W2891294324 creator A5083714802 @default.
- W2891294324 date "2018-09-13" @default.
- W2891294324 modified "2023-10-18" @default.
- W2891294324 title "A comprehensive analysis of RNA sequences reveals macroscopic somatic clonal expansion across normal tissues" @default.
- W2891294324 cites W1778436402 @default.
- W2891294324 cites W1956871134 @default.
- W2891294324 cites W1958068799 @default.
- W2891294324 cites W1971050728 @default.
- W2891294324 cites W1980740976 @default.
- W2891294324 cites W1985271346 @default.
- W2891294324 cites W1986076152 @default.
- W2891294324 cites W1993023683 @default.
- W2891294324 cites W1995068068 @default.
- W2891294324 cites W1995706959 @default.
- W2891294324 cites W2003665515 @default.
- W2891294324 cites W2004224646 @default.
- W2891294324 cites W2009720434 @default.
- W2891294324 cites W2009916940 @default.
- W2891294324 cites W2012753533 @default.
- W2891294324 cites W2018838463 @default.
- W2891294324 cites W2020534880 @default.
- W2891294324 cites W2021029116 @default.
- W2891294324 cites W2028640227 @default.
- W2891294324 cites W2031620785 @default.
- W2891294324 cites W2043676834 @default.
- W2891294324 cites W2048015797 @default.
- W2891294324 cites W2052990651 @default.
- W2891294324 cites W2054584406 @default.
- W2891294324 cites W2059437408 @default.
- W2891294324 cites W2065121554 @default.
- W2891294324 cites W2065163203 @default.
- W2891294324 cites W2065890382 @default.
- W2891294324 cites W2068183346 @default.
- W2891294324 cites W2069120646 @default.
- W2891294324 cites W2073440691 @default.
- W2891294324 cites W2080659813 @default.
- W2891294324 cites W2086535578 @default.
- W2891294324 cites W2100024496 @default.
- W2891294324 cites W2101035019 @default.
- W2891294324 cites W2102278945 @default.
- W2891294324 cites W2103452905 @default.
- W2891294324 cites W2105970624 @default.
- W2891294324 cites W2107229687 @default.
- W2891294324 cites W2107356675 @default.
- W2891294324 cites W2109816625 @default.
- W2891294324 cites W2114029728 @default.
- W2891294324 cites W2114031931 @default.
- W2891294324 cites W2118151336 @default.
- W2891294324 cites W2126816979 @default.
- W2891294324 cites W2127041368 @default.
- W2891294324 cites W2130410032 @default.
- W2891294324 cites W2137786443 @default.
- W2891294324 cites W2138601221 @default.
- W2891294324 cites W2144963939 @default.
- W2891294324 cites W2149858388 @default.
- W2891294324 cites W2150677022 @default.
- W2891294324 cites W2156538352 @default.
- W2891294324 cites W2161112598 @default.
- W2891294324 cites W2161653449 @default.
- W2891294324 cites W2164511212 @default.
- W2891294324 cites W2168133698 @default.
- W2891294324 cites W2169456326 @default.
- W2891294324 cites W2173818354 @default.
- W2891294324 cites W2256016639 @default.
- W2891294324 cites W2257647775 @default.
- W2891294324 cites W2262414037 @default.
- W2891294324 cites W2266041843 @default.
- W2891294324 cites W2283458346 @default.
- W2891294324 cites W2320692565 @default.
- W2891294324 cites W2343368549 @default.
- W2891294324 cites W2346239022 @default.
- W2891294324 cites W2346990949 @default.
- W2891294324 cites W2507857874 @default.
- W2891294324 cites W2524881570 @default.
- W2891294324 cites W2580698996 @default.
- W2891294324 cites W2586537166 @default.
- W2891294324 cites W2587329007 @default.
- W2891294324 cites W2608500349 @default.
- W2891294324 cites W2619129176 @default.