Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891301185> ?p ?o ?g. }
- W2891301185 endingPage "301" @default.
- W2891301185 startingPage "293" @default.
- W2891301185 abstract "Vanillosmopsis arborea Baker has recognized economic value owing to the high content of (-)-α-bisabolol (BISA) in the essential oil of its stem (EOVA). The antinociceptive effect of EVOA has already been demonstrated, and β-cyclodextrin (βCD) is known to improve the analgesic effect of various substances.Thus, we aimed to evaluate the orofacial antinociceptive effect of a complex containing EOVA-βCD in rodents.EOVA was obtained by simple hydrodistillation, and the essential oil was complexed with βCD. The animals (n = 6/group) were treated orally with EOVA-βCD (10 or 50 mg/kg), or vehicle (control), and subjected to cutaneous orofacial nociception (formalin, capsaicin, acidic saline or glutamate), corneal (hypertonic saline) or temporomandibular (formalin) tests. The expression of FOS protein was analyzed in the spinal cord. Molecular docking was performed using the 5-HT3 and M2 receptors and BISA.The oral administration of EOVA-βCD reduced nociceptive behaviour. Moreover, EOVA-βCD decreased FOS expression. The molecular docking study indicates that BISA interacts with 5-HT3 and M2 receptors, indicating the potential mechanism of action of the tested compound.Our results indicate that EOVA-βCD possesses orofacial antinociceptive effect, indicating that this complex can be used in analgesic drug development." @default.
- W2891301185 created "2018-09-27" @default.
- W2891301185 creator A5002706119 @default.
- W2891301185 creator A5012477217 @default.
- W2891301185 creator A5017142691 @default.
- W2891301185 creator A5018204356 @default.
- W2891301185 creator A5038781146 @default.
- W2891301185 creator A5040651147 @default.
- W2891301185 creator A5044191128 @default.
- W2891301185 creator A5054485146 @default.
- W2891301185 creator A5054702206 @default.
- W2891301185 creator A5057426183 @default.
- W2891301185 creator A5064606609 @default.
- W2891301185 creator A5076519526 @default.
- W2891301185 creator A5085004030 @default.
- W2891301185 creator A5086982037 @default.
- W2891301185 creator A5087887113 @default.
- W2891301185 date "2019-03-01" @default.
- W2891301185 modified "2023-09-27" @default.
- W2891301185 title "Molecular mechanism underlying orofacial antinociceptive activity of Vanillosmopsis arborea Baker (Asteraceae) essential oil complexed with β-cyclodextrin" @default.
- W2891301185 cites W1558926208 @default.
- W2891301185 cites W1704129926 @default.
- W2891301185 cites W1967818442 @default.
- W2891301185 cites W1976502580 @default.
- W2891301185 cites W1978662886 @default.
- W2891301185 cites W1988353440 @default.
- W2891301185 cites W1989213752 @default.
- W2891301185 cites W1995642991 @default.
- W2891301185 cites W1998568795 @default.
- W2891301185 cites W2000574545 @default.
- W2891301185 cites W2002940466 @default.
- W2891301185 cites W2004533645 @default.
- W2891301185 cites W2018784201 @default.
- W2891301185 cites W2043855224 @default.
- W2891301185 cites W2044609602 @default.
- W2891301185 cites W2051994079 @default.
- W2891301185 cites W2065994433 @default.
- W2891301185 cites W2068198548 @default.
- W2891301185 cites W2077422152 @default.
- W2891301185 cites W2084622458 @default.
- W2891301185 cites W2114367386 @default.
- W2891301185 cites W2117569182 @default.
- W2891301185 cites W2124759299 @default.
- W2891301185 cites W2130958310 @default.
- W2891301185 cites W2157133757 @default.
- W2891301185 cites W2157342556 @default.
- W2891301185 cites W2413042852 @default.
- W2891301185 cites W2414261162 @default.
- W2891301185 cites W2440399587 @default.
- W2891301185 cites W2443840999 @default.
- W2891301185 cites W2558347679 @default.
- W2891301185 cites W2612255874 @default.
- W2891301185 doi "https://doi.org/10.1016/j.phymed.2018.09.173" @default.
- W2891301185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30293859" @default.
- W2891301185 hasPublicationYear "2019" @default.
- W2891301185 type Work @default.
- W2891301185 sameAs 2891301185 @default.
- W2891301185 citedByCount "12" @default.
- W2891301185 countsByYear W28913011852020 @default.
- W2891301185 countsByYear W28913011852021 @default.
- W2891301185 countsByYear W28913011852022 @default.
- W2891301185 countsByYear W28913011852023 @default.
- W2891301185 crossrefType "journal-article" @default.
- W2891301185 hasAuthorship W2891301185A5002706119 @default.
- W2891301185 hasAuthorship W2891301185A5012477217 @default.
- W2891301185 hasAuthorship W2891301185A5017142691 @default.
- W2891301185 hasAuthorship W2891301185A5018204356 @default.
- W2891301185 hasAuthorship W2891301185A5038781146 @default.
- W2891301185 hasAuthorship W2891301185A5040651147 @default.
- W2891301185 hasAuthorship W2891301185A5044191128 @default.
- W2891301185 hasAuthorship W2891301185A5054485146 @default.
- W2891301185 hasAuthorship W2891301185A5054702206 @default.
- W2891301185 hasAuthorship W2891301185A5057426183 @default.
- W2891301185 hasAuthorship W2891301185A5064606609 @default.
- W2891301185 hasAuthorship W2891301185A5076519526 @default.
- W2891301185 hasAuthorship W2891301185A5085004030 @default.
- W2891301185 hasAuthorship W2891301185A5086982037 @default.
- W2891301185 hasAuthorship W2891301185A5087887113 @default.
- W2891301185 hasConcept C126838900 @default.
- W2891301185 hasConcept C15490471 @default.
- W2891301185 hasConcept C170493617 @default.
- W2891301185 hasConcept C185592680 @default.
- W2891301185 hasConcept C202751555 @default.
- W2891301185 hasConcept C2776120743 @default.
- W2891301185 hasConcept C2777278459 @default.
- W2891301185 hasConcept C2777397205 @default.
- W2891301185 hasConcept C2780051329 @default.
- W2891301185 hasConcept C2780820201 @default.
- W2891301185 hasConcept C2781463296 @default.
- W2891301185 hasConcept C31903555 @default.
- W2891301185 hasConcept C42219234 @default.
- W2891301185 hasConcept C55493867 @default.
- W2891301185 hasConcept C71924100 @default.
- W2891301185 hasConcept C98274493 @default.
- W2891301185 hasConceptScore W2891301185C126838900 @default.
- W2891301185 hasConceptScore W2891301185C15490471 @default.
- W2891301185 hasConceptScore W2891301185C170493617 @default.
- W2891301185 hasConceptScore W2891301185C185592680 @default.