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- W2891310773 abstract "AIMOF THE STUDY: To evaluate the safety and pharmacological profile of the test drug “Inji Dravagam” in animal model. OBJECTIVES: 1. Review of various information both (Siddha and modern) relevant to the study.2. Preparation of the trial drug as per classical Siddha literature.3. Analysis of the trial drug(a) Pytochemical analysis.(b) Chemical analysis to evaluate acid and basic radicals.(c) Gas Chromatography.(d) ICP-OES.4. Toxicity study:(a) Acute oral toxicity study (OECD - 423 Guideline)(b) 28 days Repeated oral toxicity (OECD - 407 Guideline)(c) 90 days Repeated oral toxicity (OECD - 408 Guideline)5. Pharmacology activity in wistar albino rats and mice:(a) Anti ulcer activity (Aspirin induced method)(b) Anti inflammatory activity (Cotton pellet induced granuloma method).(c) Analgesic activity (EDDy’s Hot plate method).SUMMARY:The literary evidence of the drug Inji Dravagam strongly support that it possesses anti-ulcer activity, Anti-inflammatory activity and analgesic activity for thatpurpose it has been selected for this study.The qualitative chemical analysis was done at Biochemistry lab, NIS. chemical analysis of the drug Inji Dravagam reveals that the presence of calcium,, Chloride, ammonium and Alkaloid.Preclinical evaluation (acute, sub-acute and sub-chronic toxicity study) of the drug was carried out as per OECD guideline acute, and Sub-acute was carried out in K Kcollege of pharmacy and sub chronic toxicity study were carried out in pharmacological lab and animal house, NIS, Chennai. This study reveals no significant toxic effect of the Inji Dravagam upto the higher dose level 10ml/kgused in this study.Pharmacological study (Anti-ulcer activity, Anti-inflammatory activity and analgesic activity) of the drug was carried out as per OECD guideline in K K College of Pharmacy Gerubambakkam. In the pharmacological studies, the drug Inji Dravagam exhibits significant Anti-ulcer, Anti- inflammatory activity and analgesic.CONCLUSION:From the literature evidence, Physico chemical analysis, Bio chemical analysis, Toxicological evaluation and Pharmacological studies, the drug Inji Drvagam has Antiulcer, anti-inflammatory and analgesic activity. It is concluded that the drug Inji Dravagam can be used in the management of Gunmam (peptic ulcer) and the relatedGastro intestinal disorder." @default.
- W2891310773 created "2018-09-27" @default.
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- W2891310773 date "2016-05-01" @default.
- W2891310773 modified "2023-09-27" @default.
- W2891310773 title "Safety and Pharmacological Profile of Inji Dravagam" @default.
- W2891310773 hasPublicationYear "2016" @default.
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