Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891319756> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2891319756 endingPage "361" @default.
- W2891319756 startingPage "357" @default.
- W2891319756 abstract "Rectal cancer in elderly patients can be difficult to manage. Short course radiation therapy (SCRT) has shown to be effective when given immediately prior to surgery. Here we report outcomes of elderly patients who underwent SCRT either alone or prior to resection. Between 2010 and 2015, elderly patients with rectal cancer and no distant metastatic disease were identified. Symptoms at diagnosis, therapies, toxicities, and pathologic and clinical response were recorded from patient charts. The SCRT prescription dose was 5 Gy ×5 to the rectal tumor and 4 Gy ×5 to the mesorectum, omitting the iliac nodes. Twenty patients were identified with median age of 85 years (range, 71-93 years). No patient received systemic therapy. Sixty percent of patients were cT3 at diagnosis. Half underwent resection post SCRT and half received SCRT as definitive therapy. The 1- and 2-year overall survival was 75% and 54%. Overall survival did not differ between patients treated with SCRT and surgery compared to SCRT alone (P=0.8). Of the 10 surgical patients, 3 had a complete pathologic response at time of resection and 3 patients died within 2 weeks due to perioperative complications. Of patients treated with SCRT alone, 8 were symptomatic at presentation and 5 had a clinician defined symptomatic response. No patient treated with SCRT monotherapy required additional palliative measures for outflow obstruction, but 2 progressed locally and died. SCRT is well tolerated, results in pathologic complete responses in a small percentage of patients, and achieves 63% symptom improvement rate as monotherapy. A high peri-operative complication rate was observed in this small series. In elderly patients, SCRT as initial treatment with a watch and wait approach for surgery is feasible and should be evaluated prospectively." @default.
- W2891319756 created "2018-09-27" @default.
- W2891319756 creator A5012025702 @default.
- W2891319756 creator A5027943035 @default.
- W2891319756 creator A5035857272 @default.
- W2891319756 creator A5049364499 @default.
- W2891319756 creator A5091121377 @default.
- W2891319756 date "2019-04-01" @default.
- W2891319756 modified "2023-09-23" @default.
- W2891319756 title "Short course radiation therapy for rectal cancer in the elderly: can radical surgery be avoided?" @default.
- W2891319756 cites W1592964109 @default.
- W2891319756 cites W1995367187 @default.
- W2891319756 cites W2012676688 @default.
- W2891319756 cites W2025037284 @default.
- W2891319756 cites W2125452425 @default.
- W2891319756 cites W2132565869 @default.
- W2891319756 cites W2138728054 @default.
- W2891319756 cites W2152474423 @default.
- W2891319756 cites W2298062036 @default.
- W2891319756 cites W2346848079 @default.
- W2891319756 doi "https://doi.org/10.21037/jgo.2018.09.05" @default.
- W2891319756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6465496" @default.
- W2891319756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31032106" @default.
- W2891319756 hasPublicationYear "2019" @default.
- W2891319756 type Work @default.
- W2891319756 sameAs 2891319756 @default.
- W2891319756 citedByCount "6" @default.
- W2891319756 countsByYear W28913197562020 @default.
- W2891319756 countsByYear W28913197562021 @default.
- W2891319756 countsByYear W28913197562022 @default.
- W2891319756 countsByYear W28913197562023 @default.
- W2891319756 crossrefType "journal-article" @default.
- W2891319756 hasAuthorship W2891319756A5012025702 @default.
- W2891319756 hasAuthorship W2891319756A5027943035 @default.
- W2891319756 hasAuthorship W2891319756A5035857272 @default.
- W2891319756 hasAuthorship W2891319756A5049364499 @default.
- W2891319756 hasAuthorship W2891319756A5091121377 @default.
- W2891319756 hasBestOaLocation W28913197561 @default.
- W2891319756 hasConcept C121608353 @default.
- W2891319756 hasConcept C126322002 @default.
- W2891319756 hasConcept C141071460 @default.
- W2891319756 hasConcept C31174226 @default.
- W2891319756 hasConcept C509974204 @default.
- W2891319756 hasConcept C526805850 @default.
- W2891319756 hasConcept C71924100 @default.
- W2891319756 hasConceptScore W2891319756C121608353 @default.
- W2891319756 hasConceptScore W2891319756C126322002 @default.
- W2891319756 hasConceptScore W2891319756C141071460 @default.
- W2891319756 hasConceptScore W2891319756C31174226 @default.
- W2891319756 hasConceptScore W2891319756C509974204 @default.
- W2891319756 hasConceptScore W2891319756C526805850 @default.
- W2891319756 hasConceptScore W2891319756C71924100 @default.
- W2891319756 hasIssue "2" @default.
- W2891319756 hasLocation W28913197561 @default.
- W2891319756 hasLocation W28913197562 @default.
- W2891319756 hasLocation W28913197563 @default.
- W2891319756 hasLocation W28913197564 @default.
- W2891319756 hasOpenAccess W2891319756 @default.
- W2891319756 hasPrimaryLocation W28913197561 @default.
- W2891319756 hasRelatedWork W2002120878 @default.
- W2891319756 hasRelatedWork W2047967234 @default.
- W2891319756 hasRelatedWork W2327556405 @default.
- W2891319756 hasRelatedWork W2349210304 @default.
- W2891319756 hasRelatedWork W2352247659 @default.
- W2891319756 hasRelatedWork W2354785620 @default.
- W2891319756 hasRelatedWork W2375359181 @default.
- W2891319756 hasRelatedWork W2439875401 @default.
- W2891319756 hasRelatedWork W2586998360 @default.
- W2891319756 hasRelatedWork W2767618185 @default.
- W2891319756 hasVolume "10" @default.
- W2891319756 isParatext "false" @default.
- W2891319756 isRetracted "false" @default.
- W2891319756 magId "2891319756" @default.
- W2891319756 workType "article" @default.