FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891320805> ?p ?o ?g. }

• W2891320805 endingPage "1597" @default.
• W2891320805 startingPage "1585" @default.
• W2891320805 abstract "Prediction of final clinical outcomes based on early weeks of treatment can enable more effective patient care for chronic pain. Our goal was to predict, with at least 90% accuracy, 12- to 13-week outcomes for pregabalin-treated painful diabetic peripheral neuropathy (pDPN) patients based on 4 weeks of pain and pain-related sleep interference data.We utilized active treatment data from six placebo-controlled randomized controlled trials (n = 939) designed to evaluate efficacy of pregabalin for reducing pain in patients with pDPN. We implemented a three-step, trajectory-focused analytics approach based upon patient responses collected during the first 4 weeks using monotonicity, path length, frequency domain (FD), and k-nearest neighbor (kNN) methods. The first two steps were based on combinations of baseline pain, pain at 4 weeks, weekly monotonicity and path length during the first 4 weeks, and assignment of patients to one of four responder groups (based on presence/absence of 50% or 30% reduction from baseline pain at 4 and at 12/13 weeks). The third step included agreement between prediction of logistic regression of daily FD amplitudes and assignment made from kNN analyses.Step 1 correctly assigned 520/939 patients from the six studies to a responder group using a 3-metric combination approach based on unique assignment to a 50% responder group. Step 2 (applied to the remaining 419 patients) predicted an additional 121 patients, using a blend of 50% and 30% responder thresholds. Step 3 (using a combination of FD and kNN analyses) predicted 204 of the remaining 298 patients using the 50% responder threshold. Our approach correctly predicted 90.0% of all patients.By correctly predicting 12- to 13-week responder outcomes with 90% accuracy based on responses from the first month of treatment, we demonstrated the value of trajectory measures in predicting pDPN patient response to pregabalin.www.clinicaltrials.gov identifiers, NCT00156078/NCT00159679/NCT00143156/NCT00553475.Pfizer. Plain language summary available for this article." @default.
• W2891320805 created "2018-09-27" @default.
• W2891320805 creator A5003026719 @default.
• W2891320805 creator A5011493429 @default.
• W2891320805 creator A5027113964 @default.
• W2891320805 creator A5042073172 @default.
• W2891320805 creator A5059989117 @default.
• W2891320805 creator A5085596646 @default.
• W2891320805 date "2018-09-11" @default.
• W2891320805 modified "2023-10-07" @default.
• W2891320805 title "Predicting Responses to Pregabalin for Painful Diabetic Peripheral Neuropathy Based on Trajectory-Focused Patient Profiles Derived from the First 4 Weeks of Treatment" @default.
• W2891320805 cites W1474565211 @default.
• W2891320805 cites W1504268385 @default.
• W2891320805 cites W1706172459 @default.
• W2891320805 cites W1845521331 @default.
• W2891320805 cites W1945168468 @default.
• W2891320805 cites W1998166545 @default.
• W2891320805 cites W2020407769 @default.
• W2891320805 cites W2042810701 @default.
• W2891320805 cites W2065195643 @default.
• W2891320805 cites W2072336020 @default.
• W2891320805 cites W2076716839 @default.
• W2891320805 cites W2083355677 @default.
• W2891320805 cites W2086511861 @default.
• W2891320805 cites W2094962188 @default.
• W2891320805 cites W2097322592 @default.
• W2891320805 cites W2099052157 @default.
• W2891320805 cites W2102784002 @default.
• W2891320805 cites W2104818454 @default.
• W2891320805 cites W2113076747 @default.
• W2891320805 cites W2113254647 @default.
• W2891320805 cites W2113860327 @default.
• W2891320805 cites W2118079952 @default.
• W2891320805 cites W2132309748 @default.
• W2891320805 cites W2159502813 @default.
• W2891320805 cites W2159977024 @default.
• W2891320805 cites W2162391531 @default.
• W2891320805 cites W2162880285 @default.
• W2891320805 cites W2273218712 @default.
• W2891320805 cites W2360746422 @default.
• W2891320805 cites W2498574134 @default.
• W2891320805 cites W2512714081 @default.
• W2891320805 cites W2551867430 @default.
• W2891320805 cites W2736865397 @default.
• W2891320805 cites W2737448222 @default.
• W2891320805 cites W2760582720 @default.
• W2891320805 cites W2788559436 @default.
• W2891320805 cites W907660857 @default.
• W2891320805 cites W1608399948 @default.
• W2891320805 doi "https://doi.org/10.1007/s12325-018-0780-3" @default.
• W2891320805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182642" @default.
• W2891320805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206821" @default.
• W2891320805 hasPublicationYear "2018" @default.
• W2891320805 type Work @default.
• W2891320805 sameAs 2891320805 @default.
• W2891320805 citedByCount "2" @default.
• W2891320805 countsByYear W28913208052017 @default.
• W2891320805 countsByYear W28913208052022 @default.
• W2891320805 crossrefType "journal-article" @default.
• W2891320805 hasAuthorship W2891320805A5003026719 @default.
• W2891320805 hasAuthorship W2891320805A5011493429 @default.
• W2891320805 hasAuthorship W2891320805A5027113964 @default.
• W2891320805 hasAuthorship W2891320805A5042073172 @default.
• W2891320805 hasAuthorship W2891320805A5059989117 @default.
• W2891320805 hasAuthorship W2891320805A5085596646 @default.
• W2891320805 hasBestOaLocation W28913208051 @default.
• W2891320805 hasConcept C126322002 @default.
• W2891320805 hasConcept C134018914 @default.
• W2891320805 hasConcept C142724271 @default.
• W2891320805 hasConcept C151956035 @default.
• W2891320805 hasConcept C168563851 @default.
• W2891320805 hasConcept C1862650 @default.
• W2891320805 hasConcept C204787440 @default.
• W2891320805 hasConcept C27081682 @default.
• W2891320805 hasConcept C2776468701 @default.
• W2891320805 hasConcept C2779901536 @default.
• W2891320805 hasConcept C42219234 @default.
• W2891320805 hasConcept C555293320 @default.
• W2891320805 hasConcept C71924100 @default.
• W2891320805 hasConceptScore W2891320805C126322002 @default.
• W2891320805 hasConceptScore W2891320805C134018914 @default.
• W2891320805 hasConceptScore W2891320805C142724271 @default.
• W2891320805 hasConceptScore W2891320805C151956035 @default.
• W2891320805 hasConceptScore W2891320805C168563851 @default.
• W2891320805 hasConceptScore W2891320805C1862650 @default.
• W2891320805 hasConceptScore W2891320805C204787440 @default.
• W2891320805 hasConceptScore W2891320805C27081682 @default.
• W2891320805 hasConceptScore W2891320805C2776468701 @default.
• W2891320805 hasConceptScore W2891320805C2779901536 @default.
• W2891320805 hasConceptScore W2891320805C42219234 @default.
• W2891320805 hasConceptScore W2891320805C555293320 @default.
• W2891320805 hasConceptScore W2891320805C71924100 @default.
• W2891320805 hasIssue "10" @default.
• W2891320805 hasLocation W28913208051 @default.
• W2891320805 hasLocation W28913208052 @default.
• W2891320805 hasLocation W28913208053 @default.
• W2891320805 hasLocation W28913208054 @default.
• W2891320805 hasOpenAccess W2891320805 @default.

• next