Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891323493> ?p ?o ?g. }
- W2891323493 endingPage "165" @default.
- W2891323493 startingPage "156" @default.
- W2891323493 abstract "In dialysis patients, vascular morbidities are highly prevalent and linked to leukocyte extravasation, especially of polarized monocytes. Experimental data demonstrate that phenotypic changes in monocytes require Y-box binding protein-1 (YB-1) upregulation.We determined YB-1 expression in circulating and vessel-invading monocytes from healthy controls and dialysis patients to correlate results with intima plaque formation and systemic inflammation.Compared to healthy subjects, dialysis patients have fewer classical and more intermediate and non-classical monocytes. Post-translationally modified YB-1 (lysine 301/304 acetylation) is detected at high levels in the nucleus of adherent and invading CD14+CD68+ monocytes from umbilical cord and atherosclerosis-prone vessels. The content of non-acetylated YB-1 is significantly decreased (p < 0.001), whereas acetylated YB-1 is correspondingly increased (p < 0.001) throughout all monocyte subpopulations, such that the overall content remains unchanged.In dialysis patients the YB-1 acetylation status is higher with prevailing diabetes and intima plaque formation. Pro-inflammatory mediators TNFα, IL-6, uPAR, CCL2, M-CSF, progranulin, ANP, and midkine, as well as anti-inflammatory IL-10 are significantly increased in dialysis patients, emphasizing a systemic inflammatory milieu. Strong positive correlations of monocytic YB-1 content are seen with ANP, IP-10, IL-6, and IL-10 serum levels. This is the first study demonstrating an association of cold shock protein YB-1 expression with inflammation in hemodialysis patients." @default.
- W2891323493 created "2018-09-27" @default.
- W2891323493 creator A5003737225 @default.
- W2891323493 creator A5014955648 @default.
- W2891323493 creator A5027206193 @default.
- W2891323493 creator A5047932077 @default.
- W2891323493 creator A5048889107 @default.
- W2891323493 creator A5050024715 @default.
- W2891323493 creator A5050295097 @default.
- W2891323493 creator A5057696929 @default.
- W2891323493 creator A5071746384 @default.
- W2891323493 creator A5078645646 @default.
- W2891323493 creator A5085264071 @default.
- W2891323493 date "2018-11-01" @default.
- W2891323493 modified "2023-10-18" @default.
- W2891323493 title "Cold shock Y-box binding protein-1 acetylation status in monocytes is associated with systemic inflammation and vascular damage" @default.
- W2891323493 cites W1573781410 @default.
- W2891323493 cites W1730632510 @default.
- W2891323493 cites W1964081088 @default.
- W2891323493 cites W1969964320 @default.
- W2891323493 cites W1984378291 @default.
- W2891323493 cites W1989387938 @default.
- W2891323493 cites W1996691330 @default.
- W2891323493 cites W2016019554 @default.
- W2891323493 cites W2024267894 @default.
- W2891323493 cites W2029102082 @default.
- W2891323493 cites W2031423497 @default.
- W2891323493 cites W2034875403 @default.
- W2891323493 cites W2036638105 @default.
- W2891323493 cites W2040200807 @default.
- W2891323493 cites W2041569598 @default.
- W2891323493 cites W2043865646 @default.
- W2891323493 cites W2046839194 @default.
- W2891323493 cites W2047947957 @default.
- W2891323493 cites W2055802531 @default.
- W2891323493 cites W2063927773 @default.
- W2891323493 cites W2066094572 @default.
- W2891323493 cites W2073383592 @default.
- W2891323493 cites W2073590197 @default.
- W2891323493 cites W2094914236 @default.
- W2891323493 cites W2095004364 @default.
- W2891323493 cites W2107318020 @default.
- W2891323493 cites W2108088462 @default.
- W2891323493 cites W2112117215 @default.
- W2891323493 cites W2114319457 @default.
- W2891323493 cites W2119619318 @default.
- W2891323493 cites W2120764171 @default.
- W2891323493 cites W2125110911 @default.
- W2891323493 cites W2127328679 @default.
- W2891323493 cites W2129716877 @default.
- W2891323493 cites W2131534173 @default.
- W2891323493 cites W2132349803 @default.
- W2891323493 cites W2135784130 @default.
- W2891323493 cites W2141701614 @default.
- W2891323493 cites W2151114716 @default.
- W2891323493 cites W2332448257 @default.
- W2891323493 cites W2581445136 @default.
- W2891323493 cites W2621752677 @default.
- W2891323493 cites W2699798832 @default.
- W2891323493 cites W2704296017 @default.
- W2891323493 cites W2734083947 @default.
- W2891323493 cites W2737672707 @default.
- W2891323493 cites W2766451938 @default.
- W2891323493 doi "https://doi.org/10.1016/j.atherosclerosis.2018.09.020" @default.
- W2891323493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278358" @default.
- W2891323493 hasPublicationYear "2018" @default.
- W2891323493 type Work @default.
- W2891323493 sameAs 2891323493 @default.
- W2891323493 citedByCount "18" @default.
- W2891323493 countsByYear W28913234932019 @default.
- W2891323493 countsByYear W28913234932020 @default.
- W2891323493 countsByYear W28913234932021 @default.
- W2891323493 countsByYear W28913234932022 @default.
- W2891323493 countsByYear W28913234932023 @default.
- W2891323493 crossrefType "journal-article" @default.
- W2891323493 hasAuthorship W2891323493A5003737225 @default.
- W2891323493 hasAuthorship W2891323493A5014955648 @default.
- W2891323493 hasAuthorship W2891323493A5027206193 @default.
- W2891323493 hasAuthorship W2891323493A5047932077 @default.
- W2891323493 hasAuthorship W2891323493A5048889107 @default.
- W2891323493 hasAuthorship W2891323493A5050024715 @default.
- W2891323493 hasAuthorship W2891323493A5050295097 @default.
- W2891323493 hasAuthorship W2891323493A5057696929 @default.
- W2891323493 hasAuthorship W2891323493A5071746384 @default.
- W2891323493 hasAuthorship W2891323493A5078645646 @default.
- W2891323493 hasAuthorship W2891323493A5085264071 @default.
- W2891323493 hasConcept C126322002 @default.
- W2891323493 hasConcept C13373296 @default.
- W2891323493 hasConcept C134018914 @default.
- W2891323493 hasConcept C170493617 @default.
- W2891323493 hasConcept C17991360 @default.
- W2891323493 hasConcept C203014093 @default.
- W2891323493 hasConcept C204232928 @default.
- W2891323493 hasConcept C2776252253 @default.
- W2891323493 hasConcept C2776460901 @default.
- W2891323493 hasConcept C2776914184 @default.
- W2891323493 hasConcept C2778513237 @default.
- W2891323493 hasConcept C2779978075 @default.