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• W2891330967 abstract "In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under normoxic conditions. Such tumor cell metabolic reprogramming is regulated by factors such as hypoxia and the tumor microenvironment. In addition, dysregulation of certain signaling pathways also contributes to cancer metabolic reprogramming. Among them, the Hippo signaling pathway is a highly conserved tumor suppressor pathway. The core oncosuppressive kinase cascade of Hippo pathway inhibits the nuclear transcriptional co-activators YAP and TAZ, which are the downstream effectors of Hippo pathway and oncogenic factors in many solid cancers. YAP/TAZ function as key nodes of multiple signaling pathways and play multiple regulatory roles in cancer cells. However, their roles in cancer metabolic reprograming are less clear. In the present review, we examine progress in research into the regulatory mechanisms of YAP/TAZ on glucose metabolism, fatty acid metabolism, mevalonate metabolism, and glutamine metabolism in cancer cells. Determining the roles of YAP/TAZ in tumor energy metabolism, particularly in relation to the tumor microenvironment, will provide new strategies and targets for the selective therapy of metabolism-related cancers." @default.
• W2891330967 created "2018-09-27" @default.
• W2891330967 creator A5002229441 @default.
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• W2891330967 date "2018-09-03" @default.
• W2891330967 modified "2023-10-18" @default.
• W2891330967 title "The role of YAP/TAZ activity in cancer metabolic reprogramming" @default.
• W2891330967 cites W1900808926 @default.
• W2891330967 cites W1907833971 @default.
• W2891330967 cites W1963272969 @default.
• W2891330967 cites W1976472776 @default.
• W2891330967 cites W1977291335 @default.
• W2891330967 cites W1992294689 @default.
• W2891330967 cites W1993246426 @default.
• W2891330967 cites W1994302891 @default.
• W2891330967 cites W1995160678 @default.
• W2891330967 cites W1997335773 @default.
• W2891330967 cites W1998166655 @default.
• W2891330967 cites W2014349355 @default.
• W2891330967 cites W2014988241 @default.
• W2891330967 cites W2020511240 @default.
• W2891330967 cites W2020625439 @default.
• W2891330967 cites W2027150010 @default.
• W2891330967 cites W2042966602 @default.
• W2891330967 cites W2047517132 @default.
• W2891330967 cites W2079015343 @default.
• W2891330967 cites W2085304779 @default.
• W2891330967 cites W2085825114 @default.
• W2891330967 cites W2089999508 @default.
• W2891330967 cites W2092833704 @default.
• W2891330967 cites W2094370101 @default.
• W2891330967 cites W2094584958 @default.
• W2891330967 cites W2097365930 @default.
• W2891330967 cites W2099709490 @default.
• W2891330967 cites W2109838283 @default.
• W2891330967 cites W2118900797 @default.
• W2891330967 cites W2134956953 @default.
• W2891330967 cites W2140381750 @default.
• W2891330967 cites W2153706466 @default.
• W2891330967 cites W2159038842 @default.
• W2891330967 cites W2162730852 @default.
• W2891330967 cites W2168636113 @default.
• W2891330967 cites W2170396116 @default.
• W2891330967 cites W2176297535 @default.
• W2891330967 cites W2205463375 @default.
• W2891330967 cites W2213518729 @default.
• W2891330967 cites W2237348612 @default.
• W2891330967 cites W2254672185 @default.
• W2891330967 cites W2274646531 @default.
• W2891330967 cites W2287198619 @default.
• W2891330967 cites W2308796738 @default.
• W2891330967 cites W2322921974 @default.
• W2891330967 cites W2406626486 @default.
• W2891330967 cites W2426003472 @default.
• W2891330967 cites W2461833536 @default.
• W2891330967 cites W2469595890 @default.
• W2891330967 cites W2488256128 @default.
• W2891330967 cites W2502710489 @default.
• W2891330967 cites W2510865896 @default.
• W2891330967 cites W2517092932 @default.
• W2891330967 cites W2522492952 @default.
• W2891330967 cites W2523231115 @default.
• W2891330967 cites W2534350753 @default.
• W2891330967 cites W2556760701 @default.
• W2891330967 cites W2566090297 @default.
• W2891330967 cites W2582893389 @default.
• W2891330967 cites W2588856093 @default.
• W2891330967 cites W2604028246 @default.
• W2891330967 cites W2604165468 @default.
• W2891330967 cites W2606708502 @default.
• W2891330967 cites W2610870630 @default.
• W2891330967 cites W2633626915 @default.
• W2891330967 cites W2733406733 @default.
• W2891330967 cites W2736112762 @default.
• W2891330967 cites W2742678051 @default.
• W2891330967 cites W2753269654 @default.
• W2891330967 cites W2756068226 @default.
• W2891330967 cites W2756278028 @default.
• W2891330967 cites W2758838459 @default.
• W2891330967 cites W2759593262 @default.
• W2891330967 cites W2760798070 @default.
• W2891330967 cites W2761678878 @default.
• W2891330967 cites W2765198899 @default.
• W2891330967 cites W2766200583 @default.
• W2891330967 cites W2770278590 @default.
• W2891330967 cites W2782227398 @default.
• W2891330967 cites W2802246621 @default.
• W2891330967 cites W2811124634 @default.
• W2891330967 cites W4243903519 @default.
• W2891330967 cites W94709363 @default.
• W2891330967 doi "https://doi.org/10.1186/s12943-018-0882-1" @default.
• W2891330967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122186" @default.
• W2891330967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30176928" @default.
• W2891330967 hasPublicationYear "2018" @default.
• W2891330967 type Work @default.

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