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• W2891331807 abstract "Abstract Objectives Our study aimed to probe the effects of rosiglitazone treatment on a severe acute pancreatitis (SAP) model induced by caerulein and investigate the underlying mechanism. Methods Differentially expressed messenger RNAs (mRNAs) in the mice of a SAP group were screened out by microarray analysis. The inflammatory response pathway was obtained from the online website DAVID Bioinformatics Resources 6.8. The interactions of caerulein and its target proteins were shown by search tool for interactions of chemicals (STITCH). Functional interactions of the genes associated with pancreatitis and the target proteins of caerulein were obtained with search tool for interactions of chemicals (STRING). SAP mice were established by hourly intraperitoneal injection of caerulein. Rosiglitazone was used as treatment drug, and pancreatic inflammation was assessed. The expression of Socs3 was studied by reverse transcriptase‐polymerase chain reaction (RT‐PCR) and Western blot analysis. The expression of interleukin (IL)‐6, IL‐1b, and Egr1 were studied by RT‐PCR and Western blot analysis. Results The GSE77983 data were analyzed, and the results showed that Socs3 was overexpressed in SAP tissues. The inflammation response pathway in pancreas was selected by DAVID, STITCH, and STRING. After injection of rosiglitazone in mice, the serum levels of amylase and lipase were decreased. Furthermore, the mRNA and protein levels of Socs3 and inflammatory cytokines in pancreatic tissues were downregulated. Conclusions Rosiglitazone could protect mice with SAP from injury by downregulating Socs3 and inhibiting the inflammatory response pathway." @default.
• W2891331807 created "2018-09-27" @default.
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• W2891331807 date "2018-09-11" @default.
• W2891331807 modified "2023-09-27" @default.
• W2891331807 title "Inhibiting role of rosiglitazone in the regulation of inflammatory response and protective effects for severe acute pancreatitis in mice" @default.
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• W2891331807 doi "https://doi.org/10.1002/jcb.27440" @default.
• W2891331807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30206968" @default.
• W2891331807 hasPublicationYear "2018" @default.
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