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- W2891334253 abstract "In New Zealand, up to 97% of NZ sheep flocks are seropositive to Leptospira borgpetersenii serovar Hardjo and/or Leptospira interrogans Pomona, yet vaccination is rare. This study evaluated the impact of exposure to these serovars and of vaccination on sheep growth. One third of 2260 ewe lambs on eight farms were randomly selected and vaccinated with a primary and booster bivalent Hardjo and Pomona vaccine starting at one month of age on seven farms and at around five months of age on one farm. Repeated blood samples were taken over one (n = 6 farms, bred as ewe lambs at 7–8 months of age) or two (n = 2 farms, bred as rising 2-year-old ewes) years and tested by microscopic agglutination test to assess exposure to Hardjo and Pomona. Individual weights were recorded at the same time and modelled using a multilevel linear model accounting for within-farm clustering and repeated measures. Predicted average weights were computed and compared based on the vaccination status and within the control group based on exposure status (positive for Hardjo only, Pomona only, Hardjo and Pomona and negative) for each combination of farm and weighing episode. Statistical significance of the comparison was evaluated after adjustment for multiple comparisons. There was no difference in average weight between vaccinated and control sheep before or after vaccination in any of the flocks. The comparison between sheep seropositive for either or both serovars and seronegative sheep was inconclusive, with variations of direction and magnitude of the difference between farms and weighing episodes. In the absence of an overall growth response to vaccination, widespread adoption of vaccination would unlikely yield an economic response at the industry level. However, the inconsistency observed when comparing animals based on their exposure status suggests that the actual effect of leptospirosis on growth is difficult to predict. A study of the effect on sheep reproduction is needed to fully assess the effect of vaccination on sheep production." @default.
- W2891334253 created "2018-09-27" @default.
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- W2891334253 date "2018-11-01" @default.
- W2891334253 modified "2023-09-27" @default.
- W2891334253 title "Effects of natural infection by L. borgpetersenii serovar Hardjo type Hardjo-bovis and L. interrogans serovar Pomona, and leptospiral vaccination, on sheep growth" @default.
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- W2891334253 doi "https://doi.org/10.1016/j.prevetmed.2018.09.017" @default.
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