FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891337739> ?p ?o ?g. }

• W2891337739 endingPage "204" @default.
• W2891337739 startingPage "190" @default.
• W2891337739 abstract "Nucleotide excision repair (NER) removes many different types of DNA lesions, and NER related host factors are reported to aid recovery steps during viral integration. Here, we report the identification and characterization of a DNA repair gene Rad23 from Litopenaeus vannamei and explore its role in innate immunity of crustaceans. LvRad23 contains a1149 bp open reading frame (ORF) which encodes a 382 amino acids protein with predicted theoretical isoelectric point of 4.21. LvRad23 was ubiquitously expressed in the muscle, eyestalk, gill, stomach, heart, legs, intestine, and hepatopancreas in order from high to low and LvRad23 protein was showed to be located in the cytoplasm of Drosophila S2 cells. The homology analysis showed that it has a high sequence homology with Rad23 protein from Marsupenaeus japonicus. Vibrio alginolyticus challenge induced a remarkable up-regulation of LvRad23 mRNA in hepatopancreas. Knocking down LvRad23can interfere the NER pathway by down regulating the expression of replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). However it didn't cause any significant difference on total hemocyte count (THC) between LvRad23-silenced and non-silenced group.LvRad23-silenced then challenge with V. alginolyticus inducing high level of reactive oxygen species (ROS) and DNA damage in hemolymph. As well as decreased THC, which seriously diminished the innate immune system of L. vannamei. Meanwhile, the NER pathway was reactived by enhancing the expression of LvRad23 and promoting the production of LvPCNA to resist apoptosis and maintain proliferation of hemolymph cells in the later stage. Our results suggest that LvRad23 plays a vital role in shrimp specific immune response to V. alginolytcus through its participation in NER pathway." @default.
• W2891337739 created "2018-09-27" @default.
• W2891337739 creator A5003799076 @default.
• W2891337739 creator A5022715798 @default.
• W2891337739 creator A5023440365 @default.
• W2891337739 creator A5040164667 @default.
• W2891337739 creator A5046214153 @default.
• W2891337739 creator A5071779551 @default.
• W2891337739 creator A5072415506 @default.
• W2891337739 creator A5081492744 @default.
• W2891337739 date "2018-12-01" @default.
• W2891337739 modified "2023-09-23" @default.
• W2891337739 title "Molecular characterization and function analysis of a nucleotide excision repair gene Rad23 from Litopenaeus vannamei after Vibrio alginolyticus challenge" @default.
• W2891337739 cites W1005028082 @default.
• W2891337739 cites W1484580701 @default.
• W2891337739 cites W1525382400 @default.
• W2891337739 cites W1538484395 @default.
• W2891337739 cites W1779185681 @default.
• W2891337739 cites W1903827703 @default.
• W2891337739 cites W1969252190 @default.
• W2891337739 cites W1970831375 @default.
• W2891337739 cites W1971629768 @default.
• W2891337739 cites W1973237176 @default.
• W2891337739 cites W1975762710 @default.
• W2891337739 cites W1977349073 @default.
• W2891337739 cites W1986199300 @default.
• W2891337739 cites W1986911460 @default.
• W2891337739 cites W1990545206 @default.
• W2891337739 cites W1990841627 @default.
• W2891337739 cites W1993999276 @default.
• W2891337739 cites W1996703055 @default.
• W2891337739 cites W2000235327 @default.
• W2891337739 cites W2002865491 @default.
• W2891337739 cites W2003062145 @default.
• W2891337739 cites W2010261941 @default.
• W2891337739 cites W2013858874 @default.
• W2891337739 cites W2018929792 @default.
• W2891337739 cites W2021485188 @default.
• W2891337739 cites W2035780441 @default.
• W2891337739 cites W2038060623 @default.
• W2891337739 cites W2040633327 @default.
• W2891337739 cites W2047517144 @default.
• W2891337739 cites W2051819302 @default.
• W2891337739 cites W2052777526 @default.
• W2891337739 cites W2056149721 @default.
• W2891337739 cites W2057738454 @default.
• W2891337739 cites W2058496850 @default.
• W2891337739 cites W2063754325 @default.
• W2891337739 cites W2064333469 @default.
• W2891337739 cites W2069733467 @default.
• W2891337739 cites W2082833982 @default.
• W2891337739 cites W2089723610 @default.
• W2891337739 cites W2089733955 @default.
• W2891337739 cites W2101472561 @default.
• W2891337739 cites W2105162444 @default.
• W2891337739 cites W2107277218 @default.
• W2891337739 cites W2108444625 @default.
• W2891337739 cites W2111868018 @default.
• W2891337739 cites W2115852070 @default.
• W2891337739 cites W2121909403 @default.
• W2891337739 cites W2124652346 @default.
• W2891337739 cites W2127678435 @default.
• W2891337739 cites W2128681222 @default.
• W2891337739 cites W2132632499 @default.
• W2891337739 cites W2139210450 @default.
• W2891337739 cites W2141945706 @default.
• W2891337739 cites W2144423826 @default.
• W2891337739 cites W2158578148 @default.
• W2891337739 cites W2163813747 @default.
• W2891337739 cites W2166043527 @default.
• W2891337739 cites W2168364976 @default.
• W2891337739 cites W2222634905 @default.
• W2891337739 cites W2270639202 @default.
• W2891337739 cites W2317406676 @default.
• W2891337739 cites W2344509998 @default.
• W2891337739 cites W2462286708 @default.
• W2891337739 cites W2533155350 @default.
• W2891337739 cites W2535187540 @default.
• W2891337739 cites W2604774532 @default.
• W2891337739 doi "https://doi.org/10.1016/j.fsi.2018.09.021" @default.
• W2891337739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30195911" @default.
• W2891337739 hasPublicationYear "2018" @default.
• W2891337739 type Work @default.
• W2891337739 sameAs 2891337739 @default.
• W2891337739 citedByCount "4" @default.
• W2891337739 countsByYear W28913377392020 @default.
• W2891337739 countsByYear W28913377392022 @default.
• W2891337739 countsByYear W28913377392023 @default.
• W2891337739 crossrefType "journal-article" @default.
• W2891337739 hasAuthorship W2891337739A5003799076 @default.
• W2891337739 hasAuthorship W2891337739A5022715798 @default.
• W2891337739 hasAuthorship W2891337739A5023440365 @default.
• W2891337739 hasAuthorship W2891337739A5040164667 @default.
• W2891337739 hasAuthorship W2891337739A5046214153 @default.
• W2891337739 hasAuthorship W2891337739A5071779551 @default.
• W2891337739 hasAuthorship W2891337739A5072415506 @default.
• W2891337739 hasAuthorship W2891337739A5081492744 @default.
• W2891337739 hasConcept C100068826 @default.

• next