FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891344473> ?p ?o ?g. }

• W2891344473 endingPage "14607" @default.
• W2891344473 startingPage "14602" @default.
• W2891344473 abstract "Caseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the mitochondria-specific unfolded protein response (UPRmt ). However, its detailed function and dedicated regulation remain largely unexplored. A small molecule (D9) acts as a potent and species-selective activator of human ClpP (hClpP) by mimicking the natural chaperone ClpX. Structure-activity relationship studies highlight the importance of a halogenated benzyl motif within D9 that interacts with a unique aromatic amino acid network in hClpP. Mutational and structural studies suggest that this YYW motif tightly controls hClpP activity and regulates substrate turnover by interaction with cognate ligands. This signature motif is unique to ClpP from higher organisms and does not exist in tested bacterial homologues, allowing a species-selective analysis. Thus, D9 is a versatile tool to analyze mechanistic features of hClpP." @default.
• W2891344473 created "2018-09-27" @default.
• W2891344473 creator A5000851989 @default.
• W2891344473 creator A5001453225 @default.
• W2891344473 creator A5003359226 @default.
• W2891344473 creator A5009341454 @default.
• W2891344473 creator A5010540062 @default.
• W2891344473 creator A5043675140 @default.
• W2891344473 creator A5048928672 @default.
• W2891344473 creator A5077133303 @default.
• W2891344473 creator A5088780757 @default.
• W2891344473 creator A5089687954 @default.
• W2891344473 date "2018-09-19" @default.
• W2891344473 modified "2023-10-12" @default.
• W2891344473 title "Selective Activation of Human Caseinolytic Protease P (ClpP)" @default.
• W2891344473 cites W1480113445 @default.
• W2891344473 cites W1571361882 @default.
• W2891344473 cites W1853264433 @default.
• W2891344473 cites W1983410541 @default.
• W2891344473 cites W1989108323 @default.
• W2891344473 cites W1989249139 @default.
• W2891344473 cites W2003095772 @default.
• W2891344473 cites W2028397555 @default.
• W2891344473 cites W2044677937 @default.
• W2891344473 cites W2057325473 @default.
• W2891344473 cites W2068943015 @default.
• W2891344473 cites W2081746541 @default.
• W2891344473 cites W2086168996 @default.
• W2891344473 cites W2094900559 @default.
• W2891344473 cites W2118151336 @default.
• W2891344473 cites W2128166055 @default.
• W2891344473 cites W2129381218 @default.
• W2891344473 cites W2138951501 @default.
• W2891344473 cites W2144499030 @default.
• W2891344473 cites W2145719148 @default.
• W2891344473 cites W2163562422 @default.
• W2891344473 cites W2167790893 @default.
• W2891344473 cites W2174105878 @default.
• W2891344473 cites W2213968760 @default.
• W2891344473 cites W2296699349 @default.
• W2891344473 cites W2345724349 @default.
• W2891344473 cites W2359723791 @default.
• W2891344473 cites W2548331982 @default.
• W2891344473 cites W2756224486 @default.
• W2891344473 doi "https://doi.org/10.1002/anie.201808189" @default.
• W2891344473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30129683" @default.
• W2891344473 hasPublicationYear "2018" @default.
• W2891344473 type Work @default.
• W2891344473 sameAs 2891344473 @default.
• W2891344473 citedByCount "31" @default.
• W2891344473 countsByYear W28913444732019 @default.
• W2891344473 countsByYear W28913444732020 @default.
• W2891344473 countsByYear W28913444732021 @default.
• W2891344473 countsByYear W28913444732022 @default.
• W2891344473 countsByYear W28913444732023 @default.
• W2891344473 crossrefType "journal-article" @default.
• W2891344473 hasAuthorship W2891344473A5000851989 @default.
• W2891344473 hasAuthorship W2891344473A5001453225 @default.
• W2891344473 hasAuthorship W2891344473A5003359226 @default.
• W2891344473 hasAuthorship W2891344473A5009341454 @default.
• W2891344473 hasAuthorship W2891344473A5010540062 @default.
• W2891344473 hasAuthorship W2891344473A5043675140 @default.
• W2891344473 hasAuthorship W2891344473A5048928672 @default.
• W2891344473 hasAuthorship W2891344473A5077133303 @default.
• W2891344473 hasAuthorship W2891344473A5088780757 @default.
• W2891344473 hasAuthorship W2891344473A5089687954 @default.
• W2891344473 hasConcept C104317684 @default.
• W2891344473 hasConcept C142724271 @default.
• W2891344473 hasConcept C181199279 @default.
• W2891344473 hasConcept C185592680 @default.
• W2891344473 hasConcept C2775962898 @default.
• W2891344473 hasConcept C2776714187 @default.
• W2891344473 hasConcept C515207424 @default.
• W2891344473 hasConcept C55493867 @default.
• W2891344473 hasConcept C71924100 @default.
• W2891344473 hasConcept C86803240 @default.
• W2891344473 hasConcept C88045685 @default.
• W2891344473 hasConcept C95444343 @default.
• W2891344473 hasConceptScore W2891344473C104317684 @default.
• W2891344473 hasConceptScore W2891344473C142724271 @default.
• W2891344473 hasConceptScore W2891344473C181199279 @default.
• W2891344473 hasConceptScore W2891344473C185592680 @default.
• W2891344473 hasConceptScore W2891344473C2775962898 @default.
• W2891344473 hasConceptScore W2891344473C2776714187 @default.
• W2891344473 hasConceptScore W2891344473C515207424 @default.
• W2891344473 hasConceptScore W2891344473C55493867 @default.
• W2891344473 hasConceptScore W2891344473C71924100 @default.
• W2891344473 hasConceptScore W2891344473C86803240 @default.
• W2891344473 hasConceptScore W2891344473C88045685 @default.
• W2891344473 hasConceptScore W2891344473C95444343 @default.
• W2891344473 hasFunder F4320320879 @default.
• W2891344473 hasIssue "44" @default.
• W2891344473 hasLocation W28913444731 @default.
• W2891344473 hasLocation W28913444732 @default.
• W2891344473 hasOpenAccess W2891344473 @default.
• W2891344473 hasPrimaryLocation W28913444731 @default.
• W2891344473 hasRelatedWork W1575138297 @default.
• W2891344473 hasRelatedWork W1868923609 @default.

• next