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- W2891344493 abstract "Introduction: The immune system works by stimulating direct action against various antigens and also by means of “immune memory”. When the organism is induced by a responder to an antigenic aggression, action of several cells occurs by modeling this response, among them they are like regulatory T cells (Tregs). These represent a sub-population of CD4 + T lymphocytes characterized by the expression of the CD25 + molecule and by the nuclear factor FOXP3. Objective: To review the mechanisms of action of Tregs cells in the containment of the immune system. Methodology: The present work consists of a literature review. A localization of the articles was performed in the electronic databases Pubmed, Scielo and Lilacs, between 2012 and 2017. Results and discussion: currently, it is postulated that there are three mechanisms used by Treg cells for their abilities. What is the control of suppressive factors, including cyclic adenosine monophosphate (cAMP), suppressive cytokines such as TGF-β, direct cytolysis or negative signaling through the CTLA-4 molecule, which will inhibit cell proliferation and differentiation. The second method, soluble suppression factors, such as IL-10 cytokines, TGF-β and IL-35, or secretion of suppressive factors from antigen-presenting cells such as adenosine. The third mechanism is based on the competition for cytokines that signal through common γ-chain receptors (IL-2, IL-4 and IL-7), leading to immune cell apoptosis by growth factor deprivation. Conclusion: Tregs cells are potent regulators of the immune system that act by decreasing an immune system’s action excessively. It is believed that with a better understanding of the mechanism of action such as cells, such as Tregs seriously manipulated with a purpose to aid in the treatment of diseases with immune dysregulation." @default.
- W2891344493 created "2018-09-27" @default.
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- W2891344493 date "2018-01-01" @default.
- W2891344493 modified "2023-09-26" @default.
- W2891344493 title "Regulatory T Lymphocytes: a Powerful Regulator of the Immunological System" @default.
- W2891344493 doi "https://doi.org/10.28933/ajap-2018-05-1804" @default.
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