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• W2891348030 startingPage "11239" @default.
• W2891348030 abstract "Contact domains are closely linked to gene regulation and lineage commitment, while current understanding of contact domains and their boundaries is still limited. Here, we present a novel method HiCDB, which is constructively based on local relative insulation metric and multi-scale aggregation approach to detect contact domain boundaries (CDBs) on Hi-C maps. Compared with other ‘state-of-art’ methods, HiCDB shows improved sensitivity and specificity in determining CDBs at various Hi-C resolutions. The superiority of HiCDB enabled us to study the epigenetic features of detected CDBs and showed enrichment of architectural proteins and cell-type-specific transcription factor binding sites at CDBs. The further comparison of GM12878 and IMR90 Hi-C datasets suggested that cell-type-specific CDBs are marked by active regulatory signals and correlate with activation of nearby cell identity genes." @default.
• W2891348030 created "2018-09-27" @default.
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• W2891348030 date "2018-09-04" @default.
• W2891348030 modified "2023-10-16" @default.
• W2891348030 title "HiCDB: a sensitive and robust method for detecting contact domain boundaries" @default.
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• W2891348030 doi "https://doi.org/10.1093/nar/gky789" @default.
• W2891348030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6265446" @default.
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• W2891348030 hasPublicationYear "2018" @default.
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