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- W2891350344 endingPage "475" @default.
- W2891350344 startingPage "475" @default.
- W2891350344 abstract "Influenza A virus carries few of its own proteins, but uses them effectively to take control of the infected cells and avoid immune responses. Over the years, host shutoff, the widespread down-regulation of host gene expression, has emerged as a key process that contributes to cellular takeover in infected cells. Interestingly, multiple mechanisms of host shutoff have been described in influenza A virus, involving changes in translation, RNA synthesis and stability. Several viral proteins, notably the non-structural protein NS1, the RNA-dependent RNA polymerase and the endoribonuclease PA-X have been implicated in host shutoff. This multitude of host shutoff mechanisms indicates that host shutoff is an important component of the influenza A virus replication cycle. Here we review the various mechanisms of host shutoff in influenza A virus and the evidence that they contribute to immune evasion and/or viral replication. We also discuss what the purpose of having multiple mechanisms may be." @default.
- W2891350344 created "2018-09-27" @default.
- W2891350344 creator A5015916301 @default.
- W2891350344 creator A5062218591 @default.
- W2891350344 date "2018-09-05" @default.
- W2891350344 modified "2023-10-11" @default.
- W2891350344 title "Host Shutoff in Influenza A Virus: Many Means to an End" @default.
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