FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891354593> ?p ?o ?g. }

• W2891354593 endingPage "522" @default.
• W2891354593 startingPage "513" @default.
• W2891354593 abstract "Abstract Context Increases in heart rate were seen during the clinical program for fixed-dose combination phentermine (PHEN) and topiramate (TPM), an oral medication indicated for weight management; however, the effect on cardiovascular (CV) outcomes is uncertain. Objective The aim of the present study was to determine the extent to which the rates of major adverse CV events (MACE) in patients using PHEN and TPM (including fixed dose) differed from the MACE rates during unexposed periods. Design Retrospective cohort study. Setting MarketScan, US insurance billing data. Patients or Other Participants Patients aged &gt;18 years with ≥6 months of continuous enrollment in the database before taking PHEN and/or TPM or after stopping these medications. Interventions PHEN and TPM, taken separately and together (including fixed dose). Main Outcome Measures MACE, a composite of hospitalization for acute myocardial infarction and stroke and in-hospital CV death. Results Because the outcomes are rare and the duration of medication use was brief, few events occurred. The MACE rates among current users of PHEN/TPM, fixed-dose PHEN/TPM, and PHEN were lower than those among unexposed former users. In contrast, the rate of MACE among current users of TPM was greater than among unexposed former users [incidence rate ratio: PHEN/TPM, 0.57; 95% CI, 0.19 to 1.78; fixed-PHEN/TPM, 0.24; 95% CI, 0.03 to 1.70; PHEN, 0.56; 95% CI, 0.34 to 0.91; TPM, 1.58; 95% CI, 1.33 to 1.87). Conclusions Overall, the data indicated no increased risk of MACE for current PHEN/TPM users; however, the 95% CIs for the PHEN/TPM groups were broad, indicating that the data were compatible with a wide range of possible values." @default.
• W2891354593 created "2018-09-27" @default.
• W2891354593 creator A5001241147 @default.
• W2891354593 creator A5019598772 @default.
• W2891354593 creator A5020422631 @default.
• W2891354593 creator A5021427515 @default.
• W2891354593 creator A5044590495 @default.
• W2891354593 creator A5055978606 @default.
• W2891354593 creator A5068698577 @default.
• W2891354593 creator A5070135064 @default.
• W2891354593 creator A5072450097 @default.
• W2891354593 creator A5074005348 @default.
• W2891354593 creator A5081820292 @default.
• W2891354593 creator A5086404218 @default.
• W2891354593 date "2018-09-21" @default.
• W2891354593 modified "2023-10-18" @default.
• W2891354593 title "Cardiovascular Safety During and After Use of Phentermine and Topiramate" @default.
• W2891354593 cites W1678836173 @default.
• W2891354593 cites W1992646930 @default.
• W2891354593 cites W2104313430 @default.
• W2891354593 cites W2124477479 @default.
• W2891354593 cites W2130210878 @default.
• W2891354593 cites W2142170772 @default.
• W2891354593 cites W2150285448 @default.
• W2891354593 cites W2151022141 @default.
• W2891354593 cites W2152423343 @default.
• W2891354593 cites W2192722195 @default.
• W2891354593 cites W2560688864 @default.
• W2891354593 cites W2621885355 @default.
• W2891354593 cites W75245760 @default.
• W2891354593 doi "https://doi.org/10.1210/jc.2018-01010" @default.
• W2891354593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6318778" @default.
• W2891354593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30247575" @default.
• W2891354593 hasPublicationYear "2018" @default.
• W2891354593 type Work @default.
• W2891354593 sameAs 2891354593 @default.
• W2891354593 citedByCount "26" @default.
• W2891354593 countsByYear W28913545932019 @default.
• W2891354593 countsByYear W28913545932020 @default.
• W2891354593 countsByYear W28913545932021 @default.
• W2891354593 countsByYear W28913545932022 @default.
• W2891354593 countsByYear W28913545932023 @default.
• W2891354593 crossrefType "journal-article" @default.
• W2891354593 hasAuthorship W2891354593A5001241147 @default.
• W2891354593 hasAuthorship W2891354593A5019598772 @default.
• W2891354593 hasAuthorship W2891354593A5020422631 @default.
• W2891354593 hasAuthorship W2891354593A5021427515 @default.
• W2891354593 hasAuthorship W2891354593A5044590495 @default.
• W2891354593 hasAuthorship W2891354593A5055978606 @default.
• W2891354593 hasAuthorship W2891354593A5068698577 @default.
• W2891354593 hasAuthorship W2891354593A5070135064 @default.
• W2891354593 hasAuthorship W2891354593A5072450097 @default.
• W2891354593 hasAuthorship W2891354593A5074005348 @default.
• W2891354593 hasAuthorship W2891354593A5081820292 @default.
• W2891354593 hasAuthorship W2891354593A5086404218 @default.
• W2891354593 hasBestOaLocation W28913545931 @default.
• W2891354593 hasConcept C118552586 @default.
• W2891354593 hasConcept C126322002 @default.
• W2891354593 hasConcept C151730666 @default.
• W2891354593 hasConcept C167704817 @default.
• W2891354593 hasConcept C2777683783 @default.
• W2891354593 hasConcept C2778186239 @default.
• W2891354593 hasConcept C2778456266 @default.
• W2891354593 hasConcept C2779343474 @default.
• W2891354593 hasConcept C2780400711 @default.
• W2891354593 hasConcept C2780739214 @default.
• W2891354593 hasConcept C44249647 @default.
• W2891354593 hasConcept C500558357 @default.
• W2891354593 hasConcept C71924100 @default.
• W2891354593 hasConcept C86803240 @default.
• W2891354593 hasConceptScore W2891354593C118552586 @default.
• W2891354593 hasConceptScore W2891354593C126322002 @default.
• W2891354593 hasConceptScore W2891354593C151730666 @default.
• W2891354593 hasConceptScore W2891354593C167704817 @default.
• W2891354593 hasConceptScore W2891354593C2777683783 @default.
• W2891354593 hasConceptScore W2891354593C2778186239 @default.
• W2891354593 hasConceptScore W2891354593C2778456266 @default.
• W2891354593 hasConceptScore W2891354593C2779343474 @default.
• W2891354593 hasConceptScore W2891354593C2780400711 @default.
• W2891354593 hasConceptScore W2891354593C2780739214 @default.
• W2891354593 hasConceptScore W2891354593C44249647 @default.
• W2891354593 hasConceptScore W2891354593C500558357 @default.
• W2891354593 hasConceptScore W2891354593C71924100 @default.
• W2891354593 hasConceptScore W2891354593C86803240 @default.
• W2891354593 hasFunder F4320309557 @default.
• W2891354593 hasIssue "2" @default.
• W2891354593 hasLocation W28913545931 @default.
• W2891354593 hasLocation W28913545932 @default.
• W2891354593 hasLocation W28913545933 @default.
• W2891354593 hasOpenAccess W2891354593 @default.
• W2891354593 hasPrimaryLocation W28913545931 @default.
• W2891354593 hasRelatedWork W1537391465 @default.
• W2891354593 hasRelatedWork W1978947696 @default.
• W2891354593 hasRelatedWork W2000866847 @default.
• W2891354593 hasRelatedWork W2040555317 @default.
• W2891354593 hasRelatedWork W2084770204 @default.
• W2891354593 hasRelatedWork W2107006900 @default.
• W2891354593 hasRelatedWork W2323053513 @default.

• next