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• W2891355300 abstract "A significant proportion of patients with head andneck squamous cell carcinoma (HNSCC) are unsuitable for radicaltreatment due to factors including tumour stage, performance status (PS)and co-morbidity. Palliative radiotherapy has a useful role in the control oflocal symptoms.AIM: To assess the local symptom control of advanced HNSCC treatedwith split course hypofractionated radiotherapy. Additionally, to assess theQuality of Life (QoL); the acute toxicity to the treatment and the immediateloco-regional response.MATERIALS AND METHODS: Thirty patients of very advancedHNSCC with PS of >2 were selected. All the patients after basic work up,were planned to receive initial course of 20Gy radiation (4Gy/ 5 fractions)followed by a two week gap and then re-assessment. All patients withabsent or manageable toxicity were further treated with one more courseof 20 Gy radiation. Symptom relief was assessed before and after eachcourse of radiation. QoL was assessed using the EORTC QoLquestionnaire, before and after radiotherapy.RESULTS: Out of the study population, 70% were males, 50% belongedto age group 61-70 years and all had a PS ≥3. Oropharynx (33.3%) was thecommonest site with base of tongue (20%), the commonest subsite. Stagegrouping was IVB in 56.67% with 46.67% having a N3 node anddysphagia (43.3%) at presentation. Only 3 patients could not complete theplanned courses of RT. Good symptom relief was observed in 73.3%.Improvement in symptom scales was seen, however, functional and globalhealth scores remained low. None had more than Grade 1-2 toxicity fromfirst course. Grade 2 toxicity was seen in majority of patients after secondcourse. Overall response rate was 100% with partial response (PR) in mostcases. Median duration of response was 2 months post-treatment.CONCLUSION: Split course hypofractionated palliative RT is feasible inadvanced HNSCC and allows for shorter treatment time with acceptablesymptom relief." @default.
• W2891355300 created "2018-09-27" @default.
• W2891355300 creator A5054262799 @default.
• W2891355300 date "2015-04-01" @default.
• W2891355300 modified "2023-09-27" @default.
• W2891355300 title "Split-course hypofractionated radiotherapy for palliation of advanced head and neck squamous cell carcinoma." @default.
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