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- W2891372591 abstract "<h3>BACKGROUND:</h3> Manually-assisted coughing and mechanical insufflation-exsufflation (MI-E) are commonly used in patients with Duchenne muscular dystrophy (DMD). Few studies have compared cough peak flow (CPF) with manually-assisted coughing to other methods, such as MI-E + manually-assisted coughing. In addition, few studies have reported the reliability of the measured CPF values. This study aimed to compare CPF with different cough-assistance methods and to examine the reliability of CPF data. <h3>METHODS:</h3> The study included 12 subjects with DMD (mean age, 34 ± 8 y). CPF, CPF + manually-assisted coughing (assisted CPF), maximum insufflation capacity (MIC) + CPF (MIC-CPF), MIC + manually-assisted coughing (MIC+assisted CPF), MI-E (MI-E–CPF), and MI-E + assisted CPF were measured. A spirometer was used to compare CPF measurements obtained with each of the cough-assist techniques. The reliability of the measured CPF values was analyzed using Bland-Altman analysis. <h3>RESULTS:</h3> CPF was 59 ± 34 L/min, assisted CPF was 113 ± 32 L/min, MIC-CPF was 170 ± 30 L/min, MIC+assisted CPF was 224 ± 62 L/min, MI-E–CPF was 199 ± 40 L/min, and MI-E + assisted CPF was 240 ± 38 L/min. A fixed and proportional bias was found in the CPF measurements made with the peak flow meter and the spirometer. The average 95% CI in the difference between peak flow meter, MI-E, and CPF obtained using the spirometer were −7.45 to −1.95 and −1.45 to 4.95, respectively. Test for correlation was r = 0.54 (<i>P</i> < .001) for CPF (peak flow meter) and CPF (spirometer) and r = 0.17 (<i>P</i> = .17) in CPF (MI-E) and CPF (spirometer), respectively. <h3>CONCLUSION:</h3> MI-E + assisted CPF was the highest. The CPF measured with the peak flow meter suggested underestimation." @default.
- W2891372591 created "2018-09-27" @default.
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- W2891372591 date "2018-09-11" @default.
- W2891372591 modified "2023-10-16" @default.
- W2891372591 title "Approaches to Cough Peak Flow Measurement With Duchenne Muscular Dystrophy" @default.
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- W2891372591 doi "https://doi.org/10.4187/respcare.06124" @default.
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