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• W2891373106 abstract "Abstract Aim Patients with rheumatoid arthritis ( RA ) show lower muscle mass and a higher prevalence of sarcopenia than healthy individuals. Correlations between sarcopenia and disease activity, physical function, laboratory data and body composition at baseline were investigated in a prospective, observational study ( CHIKARA study) of RA patients. Methods Body composition was measured using a bioelectrical impedance analyzer. Parameters were compared between sarcopenia and non‐sarcopenia groups, and correlations between sarcopenia and Disease Activity Score of 28 joints – erythrocyte sedimentation rate ( DAS 28‐ ESR ), modified health assessment questionnaire, treatment, and laboratory data, including matrix metalloproteinase 3 ( MMP 3), were investigated. Results The participants were 100 patients with RA (women, 78%; mean age, 66.1 years). Mean disease duration was 5.5 years, DAS 28‐ ESR was 3.55 and the prevalence of sarcopenia was 28%. Median C‐reactive protein ( CRP ) and MMP 3 were significantly higher in the sarcopenia group (0.21 mg/dL and 103.4 ng/mL) than in the non‐sarcopenia group (0.11 mg/dL and 70.3 ng/mL). Sarcopenia was negatively correlated with weight, body mass index ( BMI ), muscle mass, body fat mass, estimated bone mass and basal metabolic rate, and positively correlated with Steinbrocker stage, CRP and MMP 3 on univariate analyses. BMI , body fat mass and MMP 3 were independently associated with sarcopenia on multivariate logistic regression analysis. When MMP 3 was ≥ 90.7 ng/mL, the odds ratio for sarcopenia was increased 3.1‐fold compared with < 90.7 ng/mL ( P = 0.018). Conclusion The prevalence of sarcopenia was 28% in patients with RA whose disease activity was mild. Low BMI , high fat mass and high MMP 3 were independently associated with sarcopenia. MMP 3 might be a useful marker for sarcopenia in patients with RA ." @default.
• W2891373106 created "2018-09-27" @default.
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• W2891373106 date "2018-09-05" @default.
• W2891373106 modified "2023-09-28" @default.
• W2891373106 title "Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis ‐ results from the <scp>CHIKARA</scp> study" @default.
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• W2891373106 doi "https://doi.org/10.1111/1756-185x.13335" @default.
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