Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891375114> ?p ?o ?g. }
- W2891375114 endingPage "469" @default.
- W2891375114 startingPage "462" @default.
- W2891375114 abstract "The aim of this study was to investigate the effects of dexmedetomidine before and after ischaemia in diabetic rat kidney ischaemia reperfusion (IR) injury in the experimental diabetic rat model.Data belonging to 35 rats weighing between 250 and 300 g were analysed. Diabetes mellitus (DM) was induced using streptozotocin. Groups had bilateral renal vasculature clamped for 45 min ischaemia before clamps were removed, and 4 hours reperfusion was applied. Rats were divided into five groups: Group I or nondiabetic sham group (n=7), Group II or diabetic sham group (n=7), Group III or diabetic IR group (n=7), Group IV or diabetic IR+prophylactic Dex P (before ischaemia) (n=7) and Group V or diabetic IR+therapeutic Dex T (following reperfusion) (n=7). Dexmedetomidine was administered at a dose of 100 μg kg-1 intraperitoneally. Histomorphological and biochemical methods were used to assess the blood and tissue samples.The proximal tubule injury score in the control sham group was significantly lower than in other groups. The proximal tubule and total cell damage scores of the diabetic IR group were significantly higher than the diabetic IR+Dex T group, and no significant difference was detected in the diabetic IR+Dex P group. The biochemical parameters of the IR group were significantly increased compared to Groups I and II; however, there was no significant reduction in these parameters in the groups administered dexmedetomidine.Although administration of dexmedetomidine after ischaemia in the diabetic rat renal IR model was found to be more effective on the histopathological injury scores compared to preischaemic administration, this study has not shown that dexmedetomidine provides effective and complete protection in DM." @default.
- W2891375114 created "2018-09-27" @default.
- W2891375114 creator A5009038926 @default.
- W2891375114 creator A5031992860 @default.
- W2891375114 creator A5037635531 @default.
- W2891375114 creator A5049474824 @default.
- W2891375114 creator A5050575612 @default.
- W2891375114 creator A5057139602 @default.
- W2891375114 creator A5082760520 @default.
- W2891375114 creator A5083274575 @default.
- W2891375114 creator A5084879527 @default.
- W2891375114 creator A5087905580 @default.
- W2891375114 date "2018-10-24" @default.
- W2891375114 modified "2023-10-16" @default.
- W2891375114 title "Effects of Dexmedetomidine on Renal Ischaemia Reperfusion Injury in Streptozotocin-Induced Diabetic Rats" @default.
- W2891375114 cites W1480131382 @default.
- W2891375114 cites W1981113781 @default.
- W2891375114 cites W1987370895 @default.
- W2891375114 cites W1991240049 @default.
- W2891375114 cites W1993535066 @default.
- W2891375114 cites W1996637078 @default.
- W2891375114 cites W2001403977 @default.
- W2891375114 cites W2006242329 @default.
- W2891375114 cites W2006488661 @default.
- W2891375114 cites W2016073214 @default.
- W2891375114 cites W2020017742 @default.
- W2891375114 cites W2024337247 @default.
- W2891375114 cites W2033942926 @default.
- W2891375114 cites W2034659462 @default.
- W2891375114 cites W2035397803 @default.
- W2891375114 cites W2037512655 @default.
- W2891375114 cites W2040961193 @default.
- W2891375114 cites W2051258088 @default.
- W2891375114 cites W2102105613 @default.
- W2891375114 cites W2109201402 @default.
- W2891375114 cites W2112508373 @default.
- W2891375114 cites W2112710337 @default.
- W2891375114 cites W2119085035 @default.
- W2891375114 cites W2122022892 @default.
- W2891375114 cites W2124383063 @default.
- W2891375114 cites W2124842151 @default.
- W2891375114 cites W2125002446 @default.
- W2891375114 cites W2140565061 @default.
- W2891375114 cites W2149590342 @default.
- W2891375114 cites W2159258864 @default.
- W2891375114 cites W2164229584 @default.
- W2891375114 cites W2259217422 @default.
- W2891375114 cites W2300776102 @default.
- W2891375114 cites W2368844322 @default.
- W2891375114 cites W2585288703 @default.
- W2891375114 cites W2611376706 @default.
- W2891375114 cites W2615204901 @default.
- W2891375114 cites W2732932829 @default.
- W2891375114 cites W2980606165 @default.
- W2891375114 doi "https://doi.org/10.5152/tjar.2018.62592" @default.
- W2891375114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6223870" @default.
- W2891375114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30505609" @default.
- W2891375114 hasPublicationYear "2018" @default.
- W2891375114 type Work @default.
- W2891375114 sameAs 2891375114 @default.
- W2891375114 citedByCount "1" @default.
- W2891375114 countsByYear W28913751142022 @default.
- W2891375114 crossrefType "journal-article" @default.
- W2891375114 hasAuthorship W2891375114A5009038926 @default.
- W2891375114 hasAuthorship W2891375114A5031992860 @default.
- W2891375114 hasAuthorship W2891375114A5037635531 @default.
- W2891375114 hasAuthorship W2891375114A5049474824 @default.
- W2891375114 hasAuthorship W2891375114A5050575612 @default.
- W2891375114 hasAuthorship W2891375114A5057139602 @default.
- W2891375114 hasAuthorship W2891375114A5082760520 @default.
- W2891375114 hasAuthorship W2891375114A5083274575 @default.
- W2891375114 hasAuthorship W2891375114A5084879527 @default.
- W2891375114 hasAuthorship W2891375114A5087905580 @default.
- W2891375114 hasBestOaLocation W28913751141 @default.
- W2891375114 hasConcept C126322002 @default.
- W2891375114 hasConcept C134018914 @default.
- W2891375114 hasConcept C2776814716 @default.
- W2891375114 hasConcept C2779280383 @default.
- W2891375114 hasConcept C2780091579 @default.
- W2891375114 hasConcept C2781302539 @default.
- W2891375114 hasConcept C42219234 @default.
- W2891375114 hasConcept C541997718 @default.
- W2891375114 hasConcept C555293320 @default.
- W2891375114 hasConcept C71924100 @default.
- W2891375114 hasConceptScore W2891375114C126322002 @default.
- W2891375114 hasConceptScore W2891375114C134018914 @default.
- W2891375114 hasConceptScore W2891375114C2776814716 @default.
- W2891375114 hasConceptScore W2891375114C2779280383 @default.
- W2891375114 hasConceptScore W2891375114C2780091579 @default.
- W2891375114 hasConceptScore W2891375114C2781302539 @default.
- W2891375114 hasConceptScore W2891375114C42219234 @default.
- W2891375114 hasConceptScore W2891375114C541997718 @default.
- W2891375114 hasConceptScore W2891375114C555293320 @default.
- W2891375114 hasConceptScore W2891375114C71924100 @default.
- W2891375114 hasIssue "6" @default.
- W2891375114 hasLocation W28913751141 @default.
- W2891375114 hasLocation W28913751142 @default.
- W2891375114 hasLocation W28913751143 @default.