Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891375811> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2891375811 abstract "Abstract Background Although biotin interferences in TSH , FT 3, FT 4, and other biotinylated antibody‐based assays manufactured by Roche Diagnostics have been well studied, there are relatively few reports on biotin interference in biotin‐based assays manufactured by other companies. We investigated biotin interferences in TSH , FT 4, and FT 3 assays based on the LOCI (luminescent oxygen channeling assay) technology using the Dimension Vista 1500 analyzer (Siemens). Methods We prepared four serum pools using leftover specimens. Three serum pools were prepared initially for the original study but the 4 th pool was prepared three months later. The aliquots of serum pool one and two were supplemented with various amounts of biotin (50 ‐1200 ng/ mL ) followed by determination of TSH , FT 4, and FT 3 concentrations. The aliquots of third pool were also supplemented with biotin to investigate whether 1:3 dilution could identify biotin interference. Aliquots of serum pool four were supplemented with biotin in order to study reproducibility of our original data. Results We observed significantly elevated FT 3 levels at biotin concentration of 100 ng/ mL . In contrast, FT 4 levels were falsely elevated but TSH levels were falsely decreased at a biotin level of 500 ng/ mL . We also observed nonlinearity in dilution experiment. Conclusions We conclude that FT 3 assay is most susceptible to biotin interference (threshold: 100 ng/ mL ) while the FT 4 and TSH assays are less affected (threshold: 500 ng/ mL ). In addition, we also observed nonlinearity upon 1:3 dilution, which may indicate biotin interference (or interference from other compounds)." @default.
- W2891375811 created "2018-09-27" @default.
- W2891375811 creator A5055039506 @default.
- W2891375811 creator A5077003696 @default.
- W2891375811 date "2018-09-17" @default.
- W2891375811 modified "2023-09-25" @default.
- W2891375811 title "Biotin interference in TSH, FT4, and FT3 assays based on the LOCI technology: Identifying interference by dilution" @default.
- W2891375811 cites W1225123808 @default.
- W2891375811 cites W1968513811 @default.
- W2891375811 cites W2208812693 @default.
- W2891375811 cites W2318434501 @default.
- W2891375811 cites W2329517480 @default.
- W2891375811 cites W2465645327 @default.
- W2891375811 cites W2510464317 @default.
- W2891375811 cites W2510859603 @default.
- W2891375811 cites W2516933520 @default.
- W2891375811 cites W2518964348 @default.
- W2891375811 cites W2540909073 @default.
- W2891375811 cites W2590918357 @default.
- W2891375811 cites W2605903870 @default.
- W2891375811 cites W2607344223 @default.
- W2891375811 cites W2735985091 @default.
- W2891375811 cites W2755389459 @default.
- W2891375811 cites W2758889989 @default.
- W2891375811 cites W2766581052 @default.
- W2891375811 cites W2767139520 @default.
- W2891375811 doi "https://doi.org/10.1002/jcla.22667" @default.
- W2891375811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6818550" @default.
- W2891375811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30221397" @default.
- W2891375811 hasPublicationYear "2018" @default.
- W2891375811 type Work @default.
- W2891375811 sameAs 2891375811 @default.
- W2891375811 citedByCount "4" @default.
- W2891375811 countsByYear W28913758112020 @default.
- W2891375811 countsByYear W28913758112021 @default.
- W2891375811 countsByYear W28913758112022 @default.
- W2891375811 crossrefType "journal-article" @default.
- W2891375811 hasAuthorship W2891375811A5055039506 @default.
- W2891375811 hasAuthorship W2891375811A5077003696 @default.
- W2891375811 hasBestOaLocation W28913758111 @default.
- W2891375811 hasConcept C121332964 @default.
- W2891375811 hasConcept C142724271 @default.
- W2891375811 hasConcept C162356407 @default.
- W2891375811 hasConcept C171679685 @default.
- W2891375811 hasConcept C184112429 @default.
- W2891375811 hasConcept C185592680 @default.
- W2891375811 hasConcept C204628709 @default.
- W2891375811 hasConcept C204787440 @default.
- W2891375811 hasConcept C2776190903 @default.
- W2891375811 hasConcept C2778204606 @default.
- W2891375811 hasConcept C43617362 @default.
- W2891375811 hasConcept C55493867 @default.
- W2891375811 hasConcept C71924100 @default.
- W2891375811 hasConcept C96618451 @default.
- W2891375811 hasConcept C97355855 @default.
- W2891375811 hasConcept C9893847 @default.
- W2891375811 hasConceptScore W2891375811C121332964 @default.
- W2891375811 hasConceptScore W2891375811C142724271 @default.
- W2891375811 hasConceptScore W2891375811C162356407 @default.
- W2891375811 hasConceptScore W2891375811C171679685 @default.
- W2891375811 hasConceptScore W2891375811C184112429 @default.
- W2891375811 hasConceptScore W2891375811C185592680 @default.
- W2891375811 hasConceptScore W2891375811C204628709 @default.
- W2891375811 hasConceptScore W2891375811C204787440 @default.
- W2891375811 hasConceptScore W2891375811C2776190903 @default.
- W2891375811 hasConceptScore W2891375811C2778204606 @default.
- W2891375811 hasConceptScore W2891375811C43617362 @default.
- W2891375811 hasConceptScore W2891375811C55493867 @default.
- W2891375811 hasConceptScore W2891375811C71924100 @default.
- W2891375811 hasConceptScore W2891375811C96618451 @default.
- W2891375811 hasConceptScore W2891375811C97355855 @default.
- W2891375811 hasConceptScore W2891375811C9893847 @default.
- W2891375811 hasIssue "2" @default.
- W2891375811 hasLocation W28913758111 @default.
- W2891375811 hasLocation W28913758112 @default.
- W2891375811 hasLocation W28913758113 @default.
- W2891375811 hasOpenAccess W2891375811 @default.
- W2891375811 hasPrimaryLocation W28913758111 @default.
- W2891375811 hasRelatedWork W1972094005 @default.
- W2891375811 hasRelatedWork W2026593038 @default.
- W2891375811 hasRelatedWork W2067031238 @default.
- W2891375811 hasRelatedWork W2070869769 @default.
- W2891375811 hasRelatedWork W2072176055 @default.
- W2891375811 hasRelatedWork W2089496308 @default.
- W2891375811 hasRelatedWork W2293706724 @default.
- W2891375811 hasRelatedWork W2891375811 @default.
- W2891375811 hasRelatedWork W4205773778 @default.
- W2891375811 hasRelatedWork W4293102437 @default.
- W2891375811 hasVolume "33" @default.
- W2891375811 isParatext "false" @default.
- W2891375811 isRetracted "false" @default.
- W2891375811 magId "2891375811" @default.
- W2891375811 workType "article" @default.