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- W2891378987 abstract "<h3>BACKGROUND AND PURPOSE:</h3> 4D-DSA provides time-resolved 3D-DSA volumes with high temporal and spatial resolutions. The purpose of this study is to investigate a shifted least squares method to estimate the blood velocity from the 4D DSA images. Quantitative validation was performed using a flow phantom with an ultrasonic flow probe as ground truth. Quantification of blood velocity in human internal carotid arteries was compared with measurements generated from 3D phase-contrast MR imaging. <h3>MATERIALS AND METHODS:</h3> The centerlines of selected vascular segments and the time concentration curves of each voxel along the centerlines were determined from the 4D-DSA dataset. The temporal shift required to achieve a minimum difference between any point and other points along the centerline of a segment was calculated. The temporal shift as a function of centerline point position was fit to a straight line to generate the velocity. The proposed shifted least-squares method was first validated using a flow phantom study. Blood velocities were also estimated in the 14 ICAs of human subjects who had both 4D-DSA and phase-contrast MR imaging studies. Linear regression and correlation analysis were performed on both the phantom study and clinical study, respectively. <h3>RESULTS:</h3> Mean velocities of the flow phantom calculated from 4D-DSA matched very well with ultrasonic flow probe measurements with 11% relative root mean square error. Mean blood velocities of ICAs calculated from 4D-DSA correlated well with phase-contrast MR imaging measurements with Pearson correlation coefficient <i>r</i> = 0.835. <h3>CONCLUSIONS:</h3> The availability of 4D-DSA provides the opportunity to use the shifted least-squares method to estimate velocity in vessels within a 3D volume." @default.
- W2891378987 created "2018-09-27" @default.
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- W2891378987 date "2018-09-13" @default.
- W2891378987 modified "2023-10-12" @default.
- W2891378987 title "Quantification of Blood Velocity with 4D Digital Subtraction Angiography Using the Shifted Least-Squares Method" @default.
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- W2891378987 doi "https://doi.org/10.3174/ajnr.a5793" @default.
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