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- W2891382276 abstract "Background: Reoperation for isolated, locally recurrent or metachronous adenocarcinoma in the remnant pancreas after previous pancreatectomy for pancreatic adenocarcinoma is a rare clinical scenario. However, when feasible, the clinical benefit of completion pancreatectomy (CP) in this setting is not well characterized. Methods: Patients who underwent CP for pancreatic remnant adenocarcinoma following previous pancreatectomy for pancreatic adenocarcinoma at 6 academic medical centers were analyzed. Perioperative and long-term outcomes after CP were evaluated. Results: From 1995-2016, 25 patients were identified, representing 0.5% of the total number of pancreatic cancer resections at the 6 institutions during the same period (n = 4,955). Most index resections were pancreaticoduodenectomies (80%). Median interval between initial and CP was 43 months (range 15–92 months). Portal vein resection was performed in 8% of initial and 20% of CP. After CP, overall morbidity was 50%, major (grade 3 or 4) morbidity 21%, and 90-day mortality 4%. Median overall survival was 30 months after CP and 80 months after initial pancreatectomy for metachronous pancreatic adenocarcinoma. Survival after CP was not affected by the status of the remnant cancer: recurrent vs. metachronous (p = 0.6), and IPMN-related vs. not (p = 0.8). Conclusion: In patients with isolated, resectable (recurrent or metachronous) pancreatic remnant adenocarcinoma, completion pancreatectomy is associated with survival outcomes equivalent to those historically reported for primary pancreatic adenocarcinoma. Given the potential for long-term survival following resection of locally recurrent or metachronous pancreatic adenocarcinoma, surgeons should be vigilant in the postoperative surveillance of patients with resected pancreatic cancer in order to identify those in whom repeat surgical resection may be beneficial." @default.
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- W2891382276 date "2018-03-01" @default.
- W2891382276 modified "2023-09-30" @default.
- W2891382276 title "Recurrent or metachronous adenocarcinoma of the pancreatic remnant: long-term survival after completion pancreatectomy" @default.
- W2891382276 doi "https://doi.org/10.1016/j.hpb.2018.02.234" @default.
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