Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891385015> ?p ?o ?g. }
- W2891385015 endingPage "618" @default.
- W2891385015 startingPage "603" @default.
- W2891385015 abstract "Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with potentially severe inflammatory onset accompanied by a broad spectrum of disease manifestation and complications, AoSD is an unsolved challenge for clinicians with limited therapeutic options. This Review provides a comprehensive insight into the complex and heterogeneous nature of AoSD, describing biomarkers of the disease and its progression and the cytokine signalling pathways that contribute to disease. The efficacy and safety of biologic therapeutic options are also discussed, and guidance for treatment decisions is provided. Improving the approach to AoSD in the future will require much closer cooperation between paediatric and adult rheumatologists to establish common diagnostic strategies, treatment targets and goals. Adult-onset Still’s disease (AoSD) is not easily diagnosed, and treatment options are limited. This Review provides an overview of the disease and its pathogenesis, clinical trial results, therapeutic options and a plan to diagnose and clinically manage these patients." @default.
- W2891385015 created "2018-09-27" @default.
- W2891385015 creator A5015032522 @default.
- W2891385015 creator A5043776691 @default.
- W2891385015 creator A5069956157 @default.
- W2891385015 date "2018-09-14" @default.
- W2891385015 modified "2023-10-18" @default.
- W2891385015 title "Mechanisms, biomarkers and targets for adult-onset Still’s disease" @default.
- W2891385015 cites W130107031 @default.
- W2891385015 cites W1492157027 @default.
- W2891385015 cites W1502588534 @default.
- W2891385015 cites W1505641753 @default.
- W2891385015 cites W1517960418 @default.
- W2891385015 cites W1528083256 @default.
- W2891385015 cites W1570985918 @default.
- W2891385015 cites W1581139251 @default.
- W2891385015 cites W1585868534 @default.
- W2891385015 cites W1605817481 @default.
- W2891385015 cites W1614943507 @default.
- W2891385015 cites W1637884427 @default.
- W2891385015 cites W1642457845 @default.
- W2891385015 cites W16586706 @default.
- W2891385015 cites W1670573097 @default.
- W2891385015 cites W1757224638 @default.
- W2891385015 cites W1777356241 @default.
- W2891385015 cites W1803169559 @default.
- W2891385015 cites W1866413456 @default.
- W2891385015 cites W1884406443 @default.
- W2891385015 cites W1894325834 @default.
- W2891385015 cites W1897710733 @default.
- W2891385015 cites W1906123493 @default.
- W2891385015 cites W1964136868 @default.
- W2891385015 cites W1968791217 @default.
- W2891385015 cites W1971823659 @default.
- W2891385015 cites W1972409318 @default.
- W2891385015 cites W1977300424 @default.
- W2891385015 cites W1979346394 @default.
- W2891385015 cites W1980597439 @default.
- W2891385015 cites W1983059863 @default.
- W2891385015 cites W1988043439 @default.
- W2891385015 cites W1990180387 @default.
- W2891385015 cites W1995428027 @default.
- W2891385015 cites W1995730401 @default.
- W2891385015 cites W1997649617 @default.
- W2891385015 cites W1997797359 @default.
- W2891385015 cites W2000263173 @default.
- W2891385015 cites W2001825211 @default.
- W2891385015 cites W2002611667 @default.
- W2891385015 cites W2010052973 @default.
- W2891385015 cites W2010387075 @default.
- W2891385015 cites W2011565665 @default.
- W2891385015 cites W2011589128 @default.
- W2891385015 cites W2012883414 @default.
- W2891385015 cites W2015885704 @default.
- W2891385015 cites W2018915861 @default.
- W2891385015 cites W2019140289 @default.
- W2891385015 cites W2019367280 @default.
- W2891385015 cites W2022477691 @default.
- W2891385015 cites W2026254148 @default.
- W2891385015 cites W2029468231 @default.
- W2891385015 cites W2032968580 @default.
- W2891385015 cites W2033365558 @default.
- W2891385015 cites W2034490142 @default.
- W2891385015 cites W2034788366 @default.
- W2891385015 cites W2035384054 @default.
- W2891385015 cites W2035447104 @default.
- W2891385015 cites W2036539610 @default.
- W2891385015 cites W2038685376 @default.
- W2891385015 cites W2038796481 @default.
- W2891385015 cites W2039773772 @default.
- W2891385015 cites W2041084308 @default.
- W2891385015 cites W2043259568 @default.
- W2891385015 cites W2044220321 @default.
- W2891385015 cites W2048698451 @default.
- W2891385015 cites W2049128877 @default.
- W2891385015 cites W2049623193 @default.
- W2891385015 cites W2049803113 @default.
- W2891385015 cites W2050446994 @default.
- W2891385015 cites W2052504835 @default.
- W2891385015 cites W2055560694 @default.
- W2891385015 cites W2055871368 @default.
- W2891385015 cites W2056932864 @default.
- W2891385015 cites W2057232360 @default.
- W2891385015 cites W2063638233 @default.
- W2891385015 cites W2063829070 @default.
- W2891385015 cites W2067440074 @default.
- W2891385015 cites W2068353958 @default.
- W2891385015 cites W2074391948 @default.
- W2891385015 cites W2075520457 @default.
- W2891385015 cites W2081420658 @default.
- W2891385015 cites W2082442225 @default.
- W2891385015 cites W2082845288 @default.
- W2891385015 cites W2085316276 @default.
- W2891385015 cites W2086030881 @default.
- W2891385015 cites W2086144532 @default.
- W2891385015 cites W2086381449 @default.
- W2891385015 cites W2090609282 @default.
- W2891385015 cites W2092625242 @default.