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• W2891388598 endingPage "75" @default.
• W2891388598 startingPage "75" @default.
• W2891388598 abstract "The endometrium is an accessible source of mesenchymal stem cells. Most investigations of endometrial mesenchymal stem cells (eMSCs) have been conducted in humans. In animals, particularly in livestock, eMSC research is scarce. Such cells have been described in the bovine, ovine, caprine, porcine, and equine endometrium. Here we provide the state of the art of eMSCs in farm animals with a focus on the bovine species. In bovines, eMSCs have been identified during the phases of the estrous cycle, during which their functionality and the presence of eMSC-specific markers has been shown to change. Moreover, postpartum inflammation related to endometritis affects the presence and functionality of eMSCs, and prostaglandin E2 (PGE2) may be the mediator of such changes. We demonstrated that exposure to PGE2 in vitro modifies the transcriptomic profile of eMSCs, showing its potential role in the fate of stem cell activation, migration, and homing during pathological uterine inflammation in endometritis and in healthy puerperal endometrium. Farm animal research on eMSCs can be of great value in translational research for certain uterine pathologies and for immunomodulation of local responses to pathogens, hormones, and other substances. Further research is necessary in areas such as in vivo location of the niches and their immunomodulatory and anti-infective properties." @default.
• W2891388598 created "2018-09-27" @default.
• W2891388598 creator A5009043753 @default.
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• W2891388598 creator A5051472731 @default.
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• W2891388598 creator A5068013396 @default.
• W2891388598 date "2018-09-18" @default.
• W2891388598 modified "2023-10-14" @default.
• W2891388598 title "Endometrial Stem Cells in Farm Animals: Potential Role in Uterine Physiology and Pathology" @default.
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