Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891389725> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2891389725 abstract "e21549 Background: Data on isolated limb perfusion (ILP) in elderly melanoma patients is scarce. We aimed to evaluate the efficacy and safety of ILP in our institutional cohort of melanoma patients. Methods: Retrospective analysis of AJCC stage IIIB/C melanoma patients who underwent ILP for locally advanced (unresectable) melanoma in-transit metastases of the limb between 2000 and 2016. Normothermic ILP (37-38 °C) was performed with either Melphalan or Melphalan and Tumor Necrosis Factor (TNF). Baseline characteristics, local toxicity (Wieberdink) and systemic toxicity, locoregional progression-free survival (PFS) and melanoma-specific survival (MSS) were assessed and prognostic factors for response to ILP, melanoma recurrence and survival were analyzed using univariable and multivariable analysis. Results: 88 patients were included. The overall response rate to ILP was 81%, with a complete response (CR) rate of 47%. Median overall locoregional PFS was 6 months, while patients with a CR had a median PFS of 16 months. Median overall MSS was 38 months. Two patients (2.3%) suffered Wieberdink IV toxicity (compartment syndrome), while no patients required amputation because of severe toxicity. Based on the median age of 70, we split patients into younger and elderly groups. Toxicity rates, response rates and locoregional PFS did not differ significantly between younger and elderly patients. CR was prognostic for improved locoregional PFS and MSS. Moreover, patients > 70 and patients with stage IIIC disease had a higher risk of melanoma-specific death. Conclusions: ILP has good and potential durable responses, but also less frequent and less severe toxicity than recently developed targeted or immune therapies, which can be reserved for progression to stage IV. This study showed that ILP is an effective and safe procedure for elderly patients ( > 70) with locally advanced melanoma of the limb." @default.
- W2891389725 created "2018-09-27" @default.
- W2891389725 creator A5000559108 @default.
- W2891389725 creator A5011423603 @default.
- W2891389725 creator A5018109293 @default.
- W2891389725 creator A5019573174 @default.
- W2891389725 creator A5031844778 @default.
- W2891389725 creator A5086335455 @default.
- W2891389725 date "2017-05-20" @default.
- W2891389725 modified "2023-10-02" @default.
- W2891389725 title "Efficacy and safety of isolated limb perfusion for melanoma in elderly patients." @default.
- W2891389725 doi "https://doi.org/10.1200/jco.2017.35.15_suppl.e21549" @default.
- W2891389725 hasPublicationYear "2017" @default.
- W2891389725 type Work @default.
- W2891389725 sameAs 2891389725 @default.
- W2891389725 citedByCount "0" @default.
- W2891389725 crossrefType "journal-article" @default.
- W2891389725 hasAuthorship W2891389725A5000559108 @default.
- W2891389725 hasAuthorship W2891389725A5011423603 @default.
- W2891389725 hasAuthorship W2891389725A5018109293 @default.
- W2891389725 hasAuthorship W2891389725A5019573174 @default.
- W2891389725 hasAuthorship W2891389725A5031844778 @default.
- W2891389725 hasAuthorship W2891389725A5086335455 @default.
- W2891389725 hasConcept C126322002 @default.
- W2891389725 hasConcept C141071460 @default.
- W2891389725 hasConcept C146957229 @default.
- W2891389725 hasConcept C177713679 @default.
- W2891389725 hasConcept C2777658100 @default.
- W2891389725 hasConcept C502942594 @default.
- W2891389725 hasConcept C71924100 @default.
- W2891389725 hasConceptScore W2891389725C126322002 @default.
- W2891389725 hasConceptScore W2891389725C141071460 @default.
- W2891389725 hasConceptScore W2891389725C146957229 @default.
- W2891389725 hasConceptScore W2891389725C177713679 @default.
- W2891389725 hasConceptScore W2891389725C2777658100 @default.
- W2891389725 hasConceptScore W2891389725C502942594 @default.
- W2891389725 hasConceptScore W2891389725C71924100 @default.
- W2891389725 hasLocation W28913897251 @default.
- W2891389725 hasOpenAccess W2891389725 @default.
- W2891389725 hasPrimaryLocation W28913897251 @default.
- W2891389725 hasRelatedWork W1966238809 @default.
- W2891389725 hasRelatedWork W2072908168 @default.
- W2891389725 hasRelatedWork W2092919893 @default.
- W2891389725 hasRelatedWork W2142445321 @default.
- W2891389725 hasRelatedWork W2166664015 @default.
- W2891389725 hasRelatedWork W2249394915 @default.
- W2891389725 hasRelatedWork W2508379154 @default.
- W2891389725 hasRelatedWork W2524803166 @default.
- W2891389725 hasRelatedWork W2581395612 @default.
- W2891389725 hasRelatedWork W2599628575 @default.
- W2891389725 hasRelatedWork W2605601444 @default.
- W2891389725 hasRelatedWork W2760246662 @default.
- W2891389725 hasRelatedWork W2765951097 @default.
- W2891389725 hasRelatedWork W2889562340 @default.
- W2891389725 hasRelatedWork W2889812225 @default.
- W2891389725 hasRelatedWork W2910498100 @default.
- W2891389725 hasRelatedWork W2912764513 @default.
- W2891389725 hasRelatedWork W2947597271 @default.
- W2891389725 hasRelatedWork W3031036500 @default.
- W2891389725 hasRelatedWork W3136868441 @default.
- W2891389725 isParatext "false" @default.
- W2891389725 isRetracted "false" @default.
- W2891389725 magId "2891389725" @default.
- W2891389725 workType "article" @default.