FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891392256> ?p ?o ?g. }

• W2891392256 endingPage "2382" @default.
• W2891392256 startingPage "2367" @default.
• W2891392256 abstract "Amyotrophic lateral sclerosis (ALS) has variable clinical course and fatal outcome. Since inflammation plays a role in the pathogenesis of ALS, chitinase-3-like protein 1 or YKL40 has been assessed as putative biomarker of disease progression. YKL40 mRNA levels are increased in anterior horn of the spinal cord (P=0.004) in sporadic ALS (sALS) cases when compared with age-matched controls. These correlate with increased mRNA expression of microglial markers AIF1 and CD68 in the spinal cord in sALS (P=0.044 and P=0.000, respectively). YKL40 mRNA and protein expression had a tendency to increase in post-mortem frontal cortex area 8 (P=0.06 and P=0.08, respectively). Yet YKL40 immunoreactivity is restricted to a subpopulation of astrocytes in these regions. YKL40 protein levels, as revealed by enzyme-linked immunosorbent assay (ELISA), are significantly increased in the CSF in sALS (n=86) compared with age-matched controls (n=21) (P=0.045). Higher levels are found in patients with fast progression when compared with patients with slow and normal progression (P=0.008 and P=0.004, respectively), and correlates with ALS-FRS-R slope (P=0.000). Additionally, increased protein levels of neurofilament light chain (NF-L) are also found in sALS (P=0.000); highest values are found in patients with fast progression when compared with cases with slow and normal progression (P=0.005 and P=0.000, respectively), and also correlate with ALS-FRS-R slope (P=0.000). Pearson's correlation test linked positively the increased levels of YKL40 with increased NF-L levels (P=0.013). These data point to YKL40 and NF-L protein levels in the CSF as a good biomarker combination of disease progression in sALS." @default.
• W2891392256 created "2018-09-27" @default.
• W2891392256 creator A5010636987 @default.
• W2891392256 creator A5028207834 @default.
• W2891392256 creator A5051897861 @default.
• W2891392256 creator A5064374394 @default.
• W2891392256 creator A5065166972 @default.
• W2891392256 creator A5069275518 @default.
• W2891392256 date "2018-09-13" @default.
• W2891392256 modified "2023-10-17" @default.
• W2891392256 title "YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression" @default.
• W2891392256 cites W1547269063 @default.
• W2891392256 cites W1585095351 @default.
• W2891392256 cites W1592831338 @default.
• W2891392256 cites W1604996988 @default.
• W2891392256 cites W1608227058 @default.
• W2891392256 cites W1897821035 @default.
• W2891392256 cites W1907316588 @default.
• W2891392256 cites W1927582128 @default.
• W2891392256 cites W1931861387 @default.
• W2891392256 cites W1933848317 @default.
• W2891392256 cites W1964968979 @default.
• W2891392256 cites W1966365399 @default.
• W2891392256 cites W1966720891 @default.
• W2891392256 cites W1982662626 @default.
• W2891392256 cites W2022375226 @default.
• W2891392256 cites W2027072680 @default.
• W2891392256 cites W2028097575 @default.
• W2891392256 cites W2032288008 @default.
• W2891392256 cites W2032514423 @default.
• W2891392256 cites W2033219421 @default.
• W2891392256 cites W2033805494 @default.
• W2891392256 cites W2035357370 @default.
• W2891392256 cites W2035989157 @default.
• W2891392256 cites W2037174641 @default.
• W2891392256 cites W2039521806 @default.
• W2891392256 cites W2040578796 @default.
• W2891392256 cites W2042311402 @default.
• W2891392256 cites W2054287431 @default.
• W2891392256 cites W2054637685 @default.
• W2891392256 cites W2058742494 @default.
• W2891392256 cites W2067396413 @default.
• W2891392256 cites W2069842601 @default.
• W2891392256 cites W2070870122 @default.
• W2891392256 cites W2071239143 @default.
• W2891392256 cites W2086639871 @default.
• W2891392256 cites W2095685454 @default.
• W2891392256 cites W2096562496 @default.
• W2891392256 cites W2098787356 @default.
• W2891392256 cites W2099556150 @default.
• W2891392256 cites W2103825172 @default.
• W2891392256 cites W2105743998 @default.
• W2891392256 cites W2110625071 @default.
• W2891392256 cites W2117813875 @default.
• W2891392256 cites W2118472247 @default.
• W2891392256 cites W2122188296 @default.
• W2891392256 cites W2123568853 @default.
• W2891392256 cites W2124361740 @default.
• W2891392256 cites W2127769185 @default.
• W2891392256 cites W2134984098 @default.
• W2891392256 cites W2138751214 @default.
• W2891392256 cites W2144219560 @default.
• W2891392256 cites W2144507462 @default.
• W2891392256 cites W2151454941 @default.
• W2891392256 cites W2152575748 @default.
• W2891392256 cites W2153186903 @default.
• W2891392256 cites W2161104189 @default.
• W2891392256 cites W2166801561 @default.
• W2891392256 cites W2191098263 @default.
• W2891392256 cites W2201787692 @default.
• W2891392256 cites W2257648036 @default.
• W2891392256 cites W2257675936 @default.
• W2891392256 cites W2286969025 @default.
• W2891392256 cites W2287473555 @default.
• W2891392256 cites W2306559597 @default.
• W2891392256 cites W2322683956 @default.
• W2891392256 cites W2513665626 @default.
• W2891392256 cites W2530101855 @default.
• W2891392256 cites W2592387132 @default.
• W2891392256 cites W2594139905 @default.
• W2891392256 cites W2607829140 @default.
• W2891392256 cites W2624573790 @default.
• W2891392256 cites W2624641603 @default.
• W2891392256 cites W2738037785 @default.
• W2891392256 cites W2749719232 @default.
• W2891392256 cites W2749944343 @default.
• W2891392256 cites W2761360634 @default.
• W2891392256 cites W2761569651 @default.
• W2891392256 cites W2761955742 @default.
• W2891392256 cites W2763586225 @default.
• W2891392256 cites W2767733203 @default.
• W2891392256 cites W2769411350 @default.
• W2891392256 cites W2771354240 @default.
• W2891392256 cites W2784297687 @default.
• W2891392256 cites W2794716002 @default.
• W2891392256 cites W2803297385 @default.
• W2891392256 cites W4238341424 @default.
• W2891392256 cites W52082120 @default.

• next