Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891397000> ?p ?o ?g. }
- W2891397000 abstract "SUMMARY Aberrant display of the truncated core1 O-glycan T-antigen is a common feature of human cancer cells that correlates with metastasis. Here we show that T-antigen in Drosophila melanogaster macrophages is involved in their developmentally programmed tissue invasion. Higher macrophage T-antigen levels require an atypical major facilitator superfamily (MFS) member that we named Minerva which enables macrophage dissemination and invasion. We characterize for the first time the T and Tn glycoform O-glycoproteome of the Drosophila melanogaster embryo, and determine that Minerva increases the presence of T-antigen on protein pathways previously linked to cancer, most strongly on the protein sulfhydryl oxidase Qsox1 which we show is required for macrophage invasion. Minerva’s vertebrate ortholog, MFSD1, rescues the minerva mutant’s migration and T-antigen glycosylation defects. We thus identify a key conserved regulator that orchestrates O-glycosylation on a protein subset to activate a program governing migration steps important for both development and cancer metastasis." @default.
- W2891397000 created "2018-09-27" @default.
- W2891397000 creator A5009376579 @default.
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- W2891397000 creator A5079550765 @default.
- W2891397000 creator A5081656882 @default.
- W2891397000 date "2018-09-12" @default.
- W2891397000 modified "2023-10-17" @default.
- W2891397000 title "A conserved MFS orchestrates a subset of O-glycosylation to facilitate macrophage dissemination and tissue invasion" @default.
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