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- W2891405417 abstract "The human GLI3 protein has a dual function as a transcriptional activator or repressor of hedgehog signaling, depending on the proteolytic processing forms of GLI3. In this study, we established a compound heterozygous GLI3 mutant human embryonic stem cell line (WAe001-A-20) through CRISPR/Cas9 editing. The WAe001-A-20 cells carried two deletions on two different alleles of exon 2 of GLI3, respectively, which resulted in a frame shift and early termination in the translation of GLI3. Moreover, WAe001-A-20 maintains a normal karyotype, parental cell morphology, pluripotent phenotype and the ability to differentiate into three germ layers. Resource table." @default.
- W2891405417 created "2018-09-27" @default.
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- W2891405417 date "2018-10-01" @default.
- W2891405417 modified "2023-10-18" @default.
- W2891405417 title "Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing" @default.
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- W2891405417 doi "https://doi.org/10.1016/j.scr.2018.09.010" @default.
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