FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2891418143> ?p ?o ?g. }

• W2891418143 endingPage "2882" @default.
• W2891418143 startingPage "2882" @default.
• W2891418143 abstract "Atherosclerosis is strongly associated with cardiac dysfunction and heart failure. Besides microvascular dysfunction and diminishment of the cardiac nitric oxide-Protein Kinase G (NO-PKG) pathway, recent evidence suggests that phosphodiesterase 9A (PDE9A) enzyme has an unfavorable role in pathological changes. Here, we characterized a rabbit model that shows cardiac dysfunction as a result of an atherogenic diet, and examined the myocardial PDE9A signaling. Rabbits were divided into Control (normal diet) and HC (atherogenic diet) groups. Cardiac function was evaluated by echocardiography. Vascular function was assessed, along with serum biomarkers. Histological stains were conducted, expression of selected proteins and cyclic guanosine monophosphate (cGMP) levels were determined. Signs of diastolic dysfunction were shown in HC animals, along with concentric hypertrophy and interstitial fibrosis. Endothelial function was diminished in HC rabbits, along with marked reduction in the aortic lumen, and increased left ventricle outflow tract (LVOT) pressures. A significant increase was shown in myocardial PDE9A levels in HC animals with unchanged vasodilator-stimulated phosphoprotein (VASP) phosphorylation and cGMP levels. Upregulation of PDE9A may be associated with early stage of cardiac dysfunction in atherosclerotic conditions. Since PDE9A is involved in cGMP degradation and in deactivation of the cardioprotective PKG signaling pathway, it may become an encouraging target for future investigations in atherosclerotic diseases." @default.
• W2891418143 created "2018-09-27" @default.
• W2891418143 creator A5018677266 @default.
• W2891418143 creator A5026157237 @default.
• W2891418143 creator A5036879395 @default.
• W2891418143 creator A5040342860 @default.
• W2891418143 creator A5044635006 @default.
• W2891418143 creator A5048209631 @default.
• W2891418143 creator A5051937204 @default.
• W2891418143 creator A5065587520 @default.
• W2891418143 creator A5069607526 @default.
• W2891418143 creator A5080877919 @default.
• W2891418143 date "2018-09-22" @default.
• W2891418143 modified "2023-10-17" @default.
• W2891418143 title "Upregulation of Myocardial and Vascular Phosphodiesterase 9A in A Model of Atherosclerotic Cardiovascular Disease" @default.
• W2891418143 cites W158135656 @default.
• W2891418143 cites W164205712 @default.
• W2891418143 cites W1677674744 @default.
• W2891418143 cites W1870638042 @default.
• W2891418143 cites W1966140207 @default.
• W2891418143 cites W1969624372 @default.
• W2891418143 cites W1975906565 @default.
• W2891418143 cites W1978804120 @default.
• W2891418143 cites W1981352278 @default.
• W2891418143 cites W1991078769 @default.
• W2891418143 cites W2004075300 @default.
• W2891418143 cites W2020159180 @default.
• W2891418143 cites W2024763420 @default.
• W2891418143 cites W2029198760 @default.
• W2891418143 cites W2037919085 @default.
• W2891418143 cites W2037981049 @default.
• W2891418143 cites W2046993793 @default.
• W2891418143 cites W2069505470 @default.
• W2891418143 cites W2070247508 @default.
• W2891418143 cites W2072152755 @default.
• W2891418143 cites W2079509424 @default.
• W2891418143 cites W2079746034 @default.
• W2891418143 cites W2092322034 @default.
• W2891418143 cites W2094992315 @default.
• W2891418143 cites W2106272156 @default.
• W2891418143 cites W2116999983 @default.
• W2891418143 cites W2124624517 @default.
• W2891418143 cites W2126800040 @default.
• W2891418143 cites W2131184290 @default.
• W2891418143 cites W2133851654 @default.
• W2891418143 cites W2137319968 @default.
• W2891418143 cites W2150290935 @default.
• W2891418143 cites W2152791175 @default.
• W2891418143 cites W2158668534 @default.
• W2891418143 cites W2162025591 @default.
• W2891418143 cites W2165867908 @default.
• W2891418143 cites W2166504467 @default.
• W2891418143 cites W2170359523 @default.
• W2891418143 cites W2176863365 @default.
• W2891418143 cites W2209002211 @default.
• W2891418143 cites W2292846538 @default.
• W2891418143 cites W2306006469 @default.
• W2891418143 cites W2313186535 @default.
• W2891418143 cites W2405917310 @default.
• W2891418143 cites W2427094903 @default.
• W2891418143 cites W2441470627 @default.
• W2891418143 cites W2462116812 @default.
• W2891418143 cites W2485582514 @default.
• W2891418143 cites W2609543937 @default.
• W2891418143 cites W2649240144 @default.
• W2891418143 cites W2725090991 @default.
• W2891418143 cites W2734654741 @default.
• W2891418143 cites W2781007923 @default.
• W2891418143 cites W2790465775 @default.
• W2891418143 cites W4249896096 @default.
• W2891418143 cites W87805864 @default.
• W2891418143 doi "https://doi.org/10.3390/ijms19102882" @default.
• W2891418143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213954" @default.
• W2891418143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30249014" @default.
• W2891418143 hasPublicationYear "2018" @default.
• W2891418143 type Work @default.
• W2891418143 sameAs 2891418143 @default.
• W2891418143 citedByCount "10" @default.
• W2891418143 countsByYear W28914181432019 @default.
• W2891418143 countsByYear W28914181432020 @default.
• W2891418143 countsByYear W28914181432021 @default.
• W2891418143 countsByYear W28914181432022 @default.
• W2891418143 countsByYear W28914181432023 @default.
• W2891418143 crossrefType "journal-article" @default.
• W2891418143 hasAuthorship W2891418143A5018677266 @default.
• W2891418143 hasAuthorship W2891418143A5026157237 @default.
• W2891418143 hasAuthorship W2891418143A5036879395 @default.
• W2891418143 hasAuthorship W2891418143A5040342860 @default.
• W2891418143 hasAuthorship W2891418143A5044635006 @default.
• W2891418143 hasAuthorship W2891418143A5048209631 @default.
• W2891418143 hasAuthorship W2891418143A5051937204 @default.
• W2891418143 hasAuthorship W2891418143A5065587520 @default.
• W2891418143 hasAuthorship W2891418143A5069607526 @default.
• W2891418143 hasAuthorship W2891418143A5080877919 @default.
• W2891418143 hasBestOaLocation W28914181431 @default.
• W2891418143 hasConcept C104317684 @default.
• W2891418143 hasConcept C111566952 @default.
• W2891418143 hasConcept C120770815 @default.

• next